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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study显示文摘AIM To assess the efficacy and safety of a Chinese herbal medicine(CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia(FD). METHODS We performed a randomized, double-blind, placebocontrolled trial with patients from three centers. Two hundred and sixteen subjects diagnosed with FD according to ROME Ⅲ criteria and confirmed by upper gastrointestinal endoscopy and spleen-deficiency and Qi-stagnation syndrome were selected to receive Xiangsha Liujunzi granules or placebo for 4 wk in a 2:1 ratio by blocked randomization. The subjects also received follow-up after the 4-wk intervention. Herbal or placebo granules were dissolved in 300 m L of water. Participants in both groups were administered 130 m L(45 ℃) three times a day. Participants were evaluated prior to and following 4 wk of the intervention in terms of changes in the postprandial discomfort severity scale(PDSS) score, clinical global impression(CGI) scale score, hospital anxiety and depression scale(HADS) score, traditional Chinese medicine symptoms score(SS), scores of various domains of the 36-item short form health survey(SF-36), gastric emptying(GE) and any observed adverse effects. RESULTS Compared with the placebo group, patients in the CHM group showed significant improvements in the scores of PDSS, HADS, SS, SF-36 and CGI scale(P < 0.05 or P < 0.01). They also showed the amelioration in the GE rates of the proximal stomach and distal stomach(P < 0.05 or P < 0.01).CONCLUSION Xiangsha Liujunzi granules offered significant symptomatic improvement in patients with FD. | Lin Lv Feng-Yun Wang Xiang-Xue Ma Zhen-Hua Li Sui-Ping Huang Zhao-Hong Shi Hai-Jie Ji Li-Qun Bian Bei-Hua Zhang Ting Chen Xiao-Lan Yin Xu-Dong Tang | 2017 | World Journal of Gastroenterology2017，23，30： | 29 |
| 4 | Extending the CONSORT Statement to moxibustion显示文摘The STandards for Reporting Interventions in Clinical Trials Of Moxibustion (STRICTOM), in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM. | Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong Tang Zhi-shun Liu Jia Liu Zhi-xiu Lin Lixing Lao Ai-ping Lü Bo-li Zhang Bao-yan Liu Zhao-xiang Bian | 2013 | Journal of Integrative Medicine2013，11，1： | 27 |
| 5 | Lymph node metastasis in early gastric cancer显示文摘 | Chen Rong He Qingsheng Cui Jianxin Bian Shibo Chen Lin | 2014 | Chinese Medical Journal2014，，3： | 15 |
| 6 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 7 | Effect of NDC80 in human hepatocellular carcinoma显示文摘AIM To investigate the role of nuclear division cycle(NDC)80in human hepatocellular carcinogenesis.METHODS NDC80 gene expression was analyzed by real-time reverse transcription polymerase chain reaction in 47paired hepatocellular carcinoma(HCC)and adjacent tissues.The HCC cell line SMMC-7721 was transfected with lentivirus to silence endogenous NDC80 gene expression,which was confirmed by real-time polymerase chain reaction and western blotting.The effects of NDC80silencing on SMMC-7721 cell proliferation were evaluated by Cellomics Array Scan VTI imaging.Cell cycle analysis and apoptosis were detected with flow cytometry.Colony formation was assessed by fluorescence microscopy.RESULTS NDC80 expression levels in HCC tissues were significantly higher than those in the adjacent tissues.Functional studies demonstrated that NDC80 silencing significantly reduced SMMC-7721 cell proliferation and colony formation.Knockdown of NDC80 resulted in increased apoptosis and cell cycle arrest at S-phase.NDC80 contributed to HCC progression by reducing apoptosis and overcoming cell cycle arrest. CONCLUSION Elevated expression of NDC80 may play a role in promoting the development of HCC. | Lin-Ling Ju Lin Chen Jun-Hong Li Yi-Fan Wang Ru-Jian Lu Zhao-Lian Bian Jian-Guo Shao | 2017 | World Journal of Gastroenterology2017，23，20： | 12 |
| 8 | Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse显示文摘Modulating basal ganglia circuitry is of great signifcance in the improvement of motor function in Parkinson’s disease(PD).Here,for the frst time,we demonstrate that noninvasive ultrasound deep brain stimulation(UDBS)of the subthalamic nucleus(STN)or the globus pallidus(GP)improves motor behavior in a subacute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).Immunohistochemical c-Fos protein expression confrms that there is a relatively high level of c-Fos expression in the STN-UDBS and GP-UDBS group compared with sham group(both p<0.05).Furthermore,STN-UDBS or GPUDBS signifcantly increases the latency to fall in the rotarod test on day 9(p<0.05)and decreases the time spent climbing down a vertical rod in the pole test on day 12(p<0.05).Moreover,our results reveal that STN-UDBS or GP-UDBS protects the dopamine(DA)neurons from MPTP neurotoxicity by downregulating Bax(p<0.001),upregulating Bcl-2(p<0.01),blocking cytochrome c(Cyt C)release from mitochondria(p<0.05),and reducing cleaved-caspase 3 activity(p<0.01)in the ipsilateral substantia nigra(SN).Additionally,the safety of ultrasound stimulation is characterized by hematoxylin and eosin(HE)and Nissl staining;no hemorrhage or tissue damage is detected.Tese data demonstrate that UDBS enables modulation of STN or GP neural activity and leads to neuroprotection in PD mice,potentially serving as a noninvasive strategy for the clinical treatment of PD. | Hui Zhou Lili Niu Long Meng Zhengrong Lin Junjie Zou Xiangxiang Xia Xiaowei Huang Wei Zhou Tianyuan Bian Hairong Zheng | 2019 | Research2019，，1： | 9 |
| 9 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 10 | Three-dimensional dynamic contrast-enhanced MR angiography for evaluating recipient vessels in orthotopic liver transplantation显示文摘BACKGROUND:With the improvement of MR technology, three-dimensional dynamic contrast-enhanced MR angiography(3D-DCE-MRA)may be the optimal vascular imaging method for preoperative evaluation of liver transplantation candidates.This study was undertaken to determine the value of 3D-DCE-MRA in the assessment of recipient vessels in orthotopic liver transplantation(OLT). METHODS:The surgical and pathological records were taken as the'gold standards'.Eighteen cases of OLT were retrospectively analyzed to assess the image quality of MRA,including the signal-to-noise ratio(SNR)in arteries and veins,depiction of vascular variation and vessel disease, and the accuracy of vascular diameter measurement. RESULTS:3D-DCE-MRA of 34 cases was carried out before OLT.The rates(excellent and good)showing hepatic arteries and portal vein for 3D-DCE-MRA were 94.1%(32/34)and 88.2%(30/34),respectively.The SNRs of the celiac axis and portal vein measurements from 3D-DCE-MRA were 20.58±3.74 and 13.43±4.12, and the mean diameters were 3.4±0.3 mm and 13.1±3.2 mm,respectively.There were 5 cases of vessel variation according to the Michel's classification.Of the 34 patients, 18 were compared radiologically and pathologically.The accuracy of depiction of the hepatic artery and portal vein with 3D-DCE-MRA was 100%for both;3D-DCE-MRA precisely assessed 4 cases of more than moderate stenosis in hepatic arteries,2 cases of small-caliber hepatic artery 3 cases of venous stenosis at the second porta hepatis, 6 cases of collateral vasculature,1 case of portal vein thrombosis and 1 case of portal vein aneurysm;all were confirmed pathologically.CONCLUSION:3D-DCE-MRA may be the first choice for recipient vascular assessment before OLT. | Bian, Jie Sha, Lin Yang, Chao Sun, Chuan-Shu | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 8 |
| 11 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 12 | The vertical structure and seasonal changes of atmosphere ozone and temperature at Zhongshan Station over East Antarctica显示文摘The vertical structure of the atmospheric ozone and temperature as well as the seasonal variations is presented by using ozone sounding data at Zhongshan Station over East Antarctica from February, 2008 to February, 2009. The results show that the heights of thermal tropopause and ozone tropopause are mostly the same with yearly mean 7.9 and 7.4 km separately above the station. There is obvious seasonal variation in the pressure and temperature of the tropopause, manifested by the clear one-wave pattern with an opposite phase. As the turning point of the tropopause temperature is visible in autumn and faint in spring and winter, the tropopause height can be better confirmed by utilization of the changes of ozone. Seasonal variation of the tropospheric ozone of vertical distribution is not clear, relative to stratosphere. In the spring, ozone in the low level of stratosphere lost seriously. The minimum partial ozone in 14 km was 1.57 MPa only and the maximum partial ozone occurred in the up level stratosphere. In the rest of the season the ozone increases with height rising in the low level of stratosphere. The evidence shows that ozone lost in spring is closely related with low temperature of polar night and the process of PSC photochemical destruction ozone in the stratosphere. From the vertical characteristics and seasonal variation of ozone and temperature, it is meaningful to understand formation and development of Antarctic ozone deletion. | BIAN LinGen LIN Zhong ZHANG DongQi ZHENG XiangDong LU LongHua | 2012 | Science China Earth Sciences2012，55，2： | 6 |
| 13 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 14 | Response of the East Asian climate system to water and heat changes of global frozen soil using NCAR CAM model显示文摘在陆地空气热和水保存的条件下面,一套敏感数字实验被设置调查东方亚洲气候系统的反应到全球冻结的土壤变化。这被介绍 supercooled 土壤水过程进社区陆地模型(CLM3.0 ) 做,它被联合了到大气的研究社区空气模型(CAM3.1 ) 的国家中心。结果显示出那:(1 ) 在在 CLM3.0 的土壤冰和土壤水之间的比率被 supercooled 土壤水过程清楚地改变。地面表面温度和土壤温度也被影响。(2 ) 欧亚(包括的东方亚洲人) 气候系统在冻结的土壤区域对热和水的变化敏感。在 1 月,阿留申群岛之土人低海水平压力发行量被加强,在 500 hPa 高堵住的乌拉尔变弱,并且东方亚洲马槽变弱。在 7 月,在阿留申群岛之土人岛区域上的海水平压力显著地被减少;在东方亚洲海洋上有在东方亚洲大陆,和积极异例上的 500 hPa geopotential 高度的否定异例。(3 ) 在 1 月,在东亚上的 850 hPa 风地的南方的部件增加,显示削弱的冬季季风。在 7 月,当在海洋上有逆旋风的异例时,气旋的异例出现在东方亚洲大陆上,加强的东方海岸夏天季风反射。(4 ) 在东亚的夏天降雨显著地变化了,包括南部的 Qinghai 西藏高原,中央长江盆,和东北中国上的实质的降水增加。夏天降雨显著地在华南和海南岛减少了,但是稍微减少了在中央并且北方中国。进一步的分析沿着 30 显示出可观的上面的空气运动吗?? | XIN YuFei WU BingYi BIAN LinGen LIU Ge ZHANG Lin LI Ren | 2012 | Chinese Science Bulletin2012，57，34： | 5 |
| 15 | Changes in the spatial scale of Beijing UHI and urban development显示文摘The seasonal and interannual variations of Beijing urban heat island (UHI) are investigated in this paper using the temperature data from 1960 to 2000 at 20 meteorological stations in the Beijing region, and then the relationship between the intensity and spatial scale of UHI and Beijing urbanization indices is analyzed and discussed. Main conclusions are the followings. First, Beijing UHI shows obvious seasonal variations, and it is strongest in winter, next in spring and autumn, and least in summer. The seasonal variation of the UHI mainly occurs in the urban area. The UHI intensity at the center of Beijing is more than 0.8℃ in winter, and only 0.5℃ in summer. Second, the intensity of Beijing HUI exhibits a clear interannual warming trend with its mean growth rate (MGR) being 0.3088℃/10 a. The MGR of HUI is largest in winter, next in spring and autumn, and least in summer, and the urban temperature increase makes a major contribution to the growth of HUI intensity. Third, since the Reform and Opening, the urbanization indices have grown several ten times or even one hundred times, the intensity of HUI has increased dramatically, and its spatial scale also expanded distinctively along with the expansion of urban architectural complexes. Fourth, the interannual variation of urbanization indices is very similar with that of HUI intensity, and their linear correlation coefficients are significant at a more than 0.001 confidence level. | YU Shuqiu, BIAN Lingen & LIN Xuechun State Key Laboratory on Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China National Climate Center, China Meteorological Administration, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 5 |
| 16 | Study on low-temperature lipase of psychrophilic bacterium 2-5-10-1 isolated from deep sea of Southern Ocean显示文摘A strain of psychrophilic bacterium, 2-5-10-1, which produces low-temperature lipase, is isolated from the deep sea of Prydz Bay in Southern Ocean. The highest lipase secretion of this strain is observed at 5 ℃ and this temperature is also for optimal growth. Tween 80 and olive oil enhance secretion of lipase. The optimal temperature and pH for lipase activity are 35 ℃ and 7.5 ℃ respectively. At 0℃, the lipase still has 37% relative enzyme activity. The lipase shows high thermolability, more than 50% activity lost after incubation at 60 ℃ for 15 min. EDTA has no effect on lipase activity, indicating the lipase activity is independent of divalent cation. In contrast, the lipase activity is inhibited drastically by Cu 2+ and Zn 2+. | Lin Xuezheng1,Yang Xiuxia2,Bian Ji1,Huang Xiaohang1 1. First Institute of Oceanography,State Oceanic Administration,Qingdao 266061,China 2. Fishery College, Ocean University of China,Qingdao 266003,China | 2003 | Acta Oceanologica Sinica2003，22，4： | 5 |
| 17 | Therapeutic mechanism of Yīn-Chén-Hāo decoction in hepatic diseases显示文摘Yīn-Chén-Hāo decoction(YCHD) is a traditional Chinese medicine formula composed of capillaris(Artemisia capillaris), gardenia(Gardenia jasminoides), and rhubarb(Rheum rhabarbarum) that is used for the treatment of damp-heat jaundice. In modern clinics, YCHD is mostly used for hepatic diseases. This review summarizes the biological activities of YCHD and its medical applications. The main active compounds of YCHD are chlorogenic acid, rhein, geniposide, emodin, and scoparone. The pharmacological actions of YCHD include inhibition of hepatic steatosis, apoptosis, necrosis, anti-inflammation, and immune regulation. YCHD could be developed as a new therapeutic strategy for the treatment of hepatic diseases. | Jian-Yuan Li Hong-Yan Cao Lin Sun Run-Fei Sun Chao Wu Yan-Qin Bian Shu Dong Ping Liu Ming-Yu Sun | 2017 | World Journal of Gastroenterology2017，23，7： | 5 |
| 18 | Contribution of moderate overall coal-bearing basin uplift to tight sand gas accumulation:case study of the Xujiahe Formation in the Sichuan Basin and the Upper Paleozoic in the Ordos Basin,China显示文摘Tight sand gas is an important unconventional gas resource occurring widely in different petroleum basins.In coal-bearing formations of the Upper Triassic in the Sichuan Basin and the Carboniferous and Permian in the Ordos Basin,coal measure strata and tight sandstone constitute widely distributed source-reservoir assemblages and form the basic conditions for the formation of large tight sand gas fields.Similar to most tight gas basins in North America,the Sichuan,and Ordos Basins,all experienced overall moderate uplift and denudation in MesoCenozoic after earlier deep burial.Coal seam adsorption principles and actual coal sample simulation experiment results show that in the course of strata uplift,pressure drops and desorption occurs in coal measure strata,resulting in the discharge of substantial free gas.This accounts for 28%—42%of total gas expulsion from source rocks.At the same time,the free gases formerly stored in the pores of coal measure source rocks were also discharged at a large scale due to volumetric expansion resulting from strata uplift and pressure drop.Based on experimental data,the gas totally discharged in the uplift period of Upper Paleozoic in the Ordos Basin,and Upper Triassic Xujiahe Formation in the Sichuan Basin is calculated as(3-6) × 10~8 m^3/km^2.Geological evidence for gas accumulation in the uplift period is found in the gas reservoir analysis of the above two basins.Firstly,natural gas discharged in the uplift period has a lighter carbon isotope ratio and lower maturity than that formed in the burial period,belonging to that generated at the early stage of source rock maturity,and is absorbed and stored in coal measure strata.Secondly,physical simulation experiment results at high-temperature and high-salinity inclusions,and almost actual geologic conditions confirm that substantial gas charging and accumulation occurred in the uplift period of the coal measure strata of the two basins.Diffusive flow is the main mode for gas accumulation in the uplift period,which probably reached 56 × 10^(12)m^3 in the uplift period of the Xujiahe Formation of the Sichuan Basin,compensating for the diffusive loss of gas in the gas reservoirs,and has an important contribution to the formation of large gas fields.The above insight has promoted the gas resource extent and potential of the coal measure tight sand uplift area;therefore,we need to reassess the areas formerly believed unfavorable where the uplift scale is large,so as to get better resource potential and exploration prospects. | Cong-Sheng Bian Wen-Zhi Zhao Hong-Jun Wang Zhi-Yong Chen Ze-Cheng Wang Guang-Di Liu Chang-Yi Zhao Yun-Peng Wang Zhao-Hui Xu Yong-Xin Li Lin Jiang | 2015 | Petroleum Science2015，12，2： | 5 |
| 19 | Mucosal-associated invariant T cells in hepatitis B virus-related liver failure显示文摘BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker. | Hong Xue Han Li Lin-Ling Ju Xu-Dong Han Tiao-Chun Cheng Xi Luo Lin Chen Jian-Guo Shao Yong-Jun She Zhao-Lian Bian | 2020 | World Journal of Gastroenterology2020，26，31： | 4 |
| 20 | Using hybrid transcription factors to study gene function in rice显示文摘Dear Editors,Transcription factors(TF)play important roles in plant growth and development,which determine crop productivity,quality,and stress tolerance.However,the basic mechanism governing transcription regulation by TF remains largely unclear in plants.It is well known that TF | ZHAO Tao LIU Jun LI Hong-Yu LIN Jian-Zhong BIAN Ming-Di ZHANG Chun-Yu ZHANG Yong-Xing PENG Yu-Chong LIU Bin LIN ChenTao | 2015 | Science China(Life Sciences)2015，58，11： | 4 |
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