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| 1 | Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling显示文摘The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen. | Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 2 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 3 | Determination of trace amount of microcystins in water samples using liquid chromatography coupled with triple quadrupole mass spectrometry显示文摘 | Liming Cong Baifen Huang Qi Chen | 2006 | Analytica Chimica Acta2006，569，12： | 1 |
| 4 | Pore evolution in hydrocarbon-generation simulation of organic matter-rich muddy shale显示文摘For exploration and potential evaluation of deep shale reservoirs with high maturity,hydrocarbon generation and pore evolution of muddy shale in deep high evolution stage were investigated by the high-temperature high-pressure simulation experiment.Results indicated that under high pressure condition,nano-scale micropores in organic matter-rich muddy shale constantly increased as rise of temperature and pressure,leading to increase of shale porosity.However,in the high mature-overmature stage,shale porosity decreased with further increase of temperature and pressure.In contrast to micropores,micro-scale capillary pores and megapores in shale constantly decreased as rise of simulation temperature or pressure,indicating that deep-burial reservoirs was not favorable for free-gas storage;but significant increase of micropores and surface area during this stage could make up for a loss of adsorbed natural gas in shale due to decrease of adsorption capacity which was induced by increase of temperature and pressure,thus leading to high shale gas potential in deep layers.A large number of secondary micropores were developed in the simulated samples such as pyrite and dolomite,demonstrating that shale clasts and mineral matrix could also form abundant secondary micropores during the deep evolution stage;during the evolution process,shale as hydrocarbon source rock could generate a large amount of acidic fluid which was favorable for development of secondary porosity. | Liming Ji Long Su Yuandong Wu Cong He | 2017 | Petroleum Research2017，2，2： | 1 |
| 5 | Development of a theoretically based thermal model for lithium ion battery pack显示文摘 | Cong Zhu Xinghu Li Lingjun Song Liming Xiang | 2013 | Journal of Power Sources2013，，： | 1 |
| 6 | Determination of trace amount of microcystins in water samples using liquid chromatography coupled with triple quadrupole mass spectrometry 显示文摘 | Liming Cong Baifen Huang Baiyi Lu | 2006 | Analytica Chimica Acta2006，569，： | 1 |
| 7 | Improving succinate production by engineering oxygen‑dependent dynamic pathway regulation in Escherichia coli显示文摘Succinate is an important building block for chemical synthesis.However,during the fermentation process,excessive osmotic stress and byproduct accumulation substantively impair the performance of the microbial cell factory.To this end,two strategies were proposed.First,an osmo-tolerant mutant,Escherichia coli FMME-N-2,was screened by combined mutagenesis(ARTP and^(60)Co-γirradiation)to produce 51.8 g L^(−1)succinate with a productivity of 0.81 g L^(−1)h^(−1).Second,an oxygen-dependent bifunctional switch(OBS)was developed with promoter PfnrF8-based activation and tobacco etch virus protease-based inhibition functions.With ribosomal binding site(RBS)and degron optimization of OBS,the optimal strain E.coli FMME-N-30 achieved a succinate titer and productivity of 119 g L^(−1)and 1.65 g L^(−1) h^(−1),respectively,in a 30-L fermentor,while only 7.1 g L^(−1)acetate and no formate or lactate were detected.Compared to the wild-type strain E.coli FMME-N,the succinate titer was increased by 3.3-fold.These results highlight the applicability of OBS for the large-scale production of value-added chemicals. | Cong Gao Wenxiu Tang Liang Guo Guipeng Hu Jia Liu Liming Liu Xiulai Chen | 2022 | Systems Microbiology and Biomanufacturing2022，2，2： | 1 |
| 8 | Sexual behavior and awareness of Chinese university students in transition with im- plied risk of sexually transmitted diseases and HIV infection: A cross-sectional study 显示文摘 | Ma Qiaoqin Ono-Kihara M Cong Liming | 2006 | BMC Public Health2006，6，： | 1 |
| 9 | Determination of trace amount of microcystins in water samples using liquid chromatography coupled with triple quadrupole mass sepctrometery显示文摘 | Liming Cong Baifen Huang Qi Chen | 2006 | Analytica Chimica Acta2006，569，： | 1 |
| 10 | The degradation of perovskite precursor显示文摘Perovskite solar cells(PSCs)are taking a leading position in thin-film optoelectronic devices due to their excellent optical,physical and electrical properties[1-4].Nevertheless,the stability issue of metal halide perovskite precursor solution severely retards the future industrialization of PSCs[5-7].In stoichiometry,slight solution composition change will induce severe degradation of device performance. | Mengjia Li Lixiu Zhang Cong Chen Jiangzhao Chen Liming Ding | 2023 | Journal of Semiconductors2023，44，1： | 0 |
| 11 | Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products显示文摘The mycelial bacterium Streptomyces is a workhorse for producing natural products,serving as a key source of drugs and other valuable chemicals.However,its complicated life cycle,silent biosynthetic gene clusters(BGCs),and poorly characterized metabolic mechanisms limit efficient production of natural products.There-fore,a metabolic engineering strategy,including traditional and emerging tools from different disciplines,was developed to further enhance natural product synthesis by Streptomyces.Here,current trends in systems metabolic engineering,including tools and strategies,are reviewed.Particularly,this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle,strategies for the activation of silent gene clusters,and the exploration of regulatory mechanisms governing antibiotic production.Finally,future challenges and prospects are discussed. | Zuwei Xu Lihao Ji Wenxiu Tang Liang Guo Cong Gao Xiulai Chen Jia Liu Guipeng Hu Liming Liu | 2022 | Engineering Microbiology2022，2，2： | 0 |
| 12 | Advances in microbial engineering for the production of value‑added products in a biorefinery显示文摘Microbial biorefineries to produce chemicals from renewable feedstock provides attractive advantages,including mild reaction conditions and sustainable manufacturing.However,low-efficiency biorefineries always result in an uncompetitive biological process compared to the current petrochemical process.Thus,improving microbial capacity to maximize product yield,productivity,and titer has been recognized as a central goal for bioengineers and biochemists.The knowledge of cellular biochemistry has enabled the regulation of microbial physiology to couple with chemical production.The rapid development in metabolic engineering provides diverse strategies to enhance the efficiency of chemical biosynthesis pathways.New synthetic biology tools as well as novel regulatory targets also offer the opportunity to improve biorefinery environmental adaptivity.In this review,the recent advances in building efficient biorefineries were showcased.In addition,the challenges and future perspectives of microbial host engineering for increased microbial capacity of a biorefinery were discussed. | Cong Gao Liang Guo Wei Song Jing Wu Xiulai Chen Liming Liu | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 13 | Mechanical pressing method for making high-quality perovskite single crystals显示文摘Halide perovskites show excellent photovoltaic properties[1−4].However,the preparation of high-quality perovskite crystals remains a great challenge,which limits their applications.Perovskite materials applied to photodetectors mainly include polycrystalline thin films and single crystals.Traditional solution methods are used to prepare polycrystalline thin films,and the films are full of defects such as voids and grain boundaries[5−7].Compared to polycrystalline thin films,perovskite single crystals possess high crystallinity and low defect density[8−10].Photodetectors based on perovskite single crystals exhibit excellent performance[11].However,the size limitation of single crystals hinders their application in photodetectors[12]. | Chenglin Wang Jie Sun Jiangzhao Chen Cong Chen Liming Ding | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 14 | Doping organic hole-transport materials for high-performance perovskite solar cells显示文摘Single-junction and tandem perovskite solar cells(PSCs)have achieved impressive power conversion efficiencies(PCEs)of 25.7%and 31.3%,respectively,which makes it to be one of next-generation photovoltaic technologies[1−9].Inter-face engineering[3,5,10−12],composition engineering[13]and ad-ditive engineering[7,14,15]have made remarkable contribu-tions to efficiency enhancement.Compared with efficiency,the long-term operational stability of PSCs jogs along,which is far from the requirements of commercialization.Currently,almost all regular n-i-p PSCs were accomplished with classic-al organic hole-transport materials(HTMs),i.e.,PTAA[16]and spiro-OMeTAD[2,4,6].However,the highly efficient PSCs with the above organic hole-transport layers(HTL)usually suffer from instability.To facilitate hole transport and extraction,LiTF-SI and tBP are frequently employed to dope organic HTLs but this would sacrifice device stability.The use of these hygro-scopic p-dopants endows the devices with poor moisture sta-bility. | Dongmei He Shirong Lu Juan Hou Cong Chen Jiangzhao Chen Liming Ding | 2023 | Journal of Semiconductors2023，44，2： | 0 |
| 15 | Dimethylammonium cation stabilizes all-inorganic perovskite solar cells显示文摘Facing the poor environmental stability of traditional methylammonium or formamidinium-based lead halide per-ovskites,scientists turn their attention to inorganic lead hal-ide perovskites(ILHPs)with narrow bandgaps,excellent thermal stability and reduced ion migration compared to their organic/inorganic counterparts[1−4].Up to now,the PCEs for ILHP solar cells exceed 21%[5].Especially,the preferred black ILHP(e.g.CsPbI3)with the smallest bandgap of~1.7 eV and single-halide composition for avoiding phase separation is crucial for high-performance single-junction solar cells and can be applied in tandem devices as the top cells[6,7].However,small Cs+(167 pm)in CsPbI3 with a tolerance factor close to 0.8 is unsuitable for the 3D PbI3-framework[8].The mis-matched size of cations will induce lattice strain and the per-ovskite spontaneously transforms to undesired non-photoact-ive yellow phase(δ-phase,like NH4CdCl3)(Fig.1(a))[9,10].There-fore,improving lattice symmetry and reducing lattice strain are the strategies for inhibiting the phase transition of ILHPs. | Zuolin Zhang Mengjia Li Jie Sun Cong Chen Jiangzhao Chen Liming Ding | 2023 | Journal of Semiconductors2023，44，3： | 0 |
| 16 | Experimental Study on Macro-micro Mechanism of the Marble during Loading Damage Process显示文摘 | Yu Cong Zaiquan Wang Liming Zhang Xiaoyu Bai | 2013 | 建筑工程(中英文版)2013，1，3： | 0 |
| 17 | Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation显示文摘Cytochrome P450 enzymes(CYPs)catalyze a series of C-H and C=C oxygenation reactions,including hydroxylation,epoxidation,and ketonization.They are attractive biocatalysts because of their ability to selectively introduce oxygen into inert molecules under mild conditions.This review provides a comprehensive overview of the C-H and C=C oxygenation reactions catalyzed by CYPs and the various strategies for achieving higher selectivity and enzymatic activity.Furthermore,we discuss the application of C-H and C=C oxygenation catalyzed by CYPs to obtain the desired chemicals or pharmaceutical intermediates in practical production.The rapid development of protein engineering for CYPs provides excellent biocatalysts for selective C-H and C=C oxygenation reactions,thereby promoting the development of environmentally friendly and sustainable production processes. | Yu Yan Jing Wu Guipeng Hu Cong Gao Liang Guo Xiulai Chen Liming Liu Wei Song | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 0 |
| 18 | Metabolic engineering strategies for microbial utilization of C1 feedstocks显示文摘The use of abundant and cheap one carbon(C1)feedstocks to produce value-added chemicals is an important approach for achieving carbon neutrality and tackling environmental problems.The conversion of C1 feedstocks to high-value chemicals is dependent on efficient C1 assimilation pathways and microbial chassis adapted for efficient incorporation.Here,we opted to summarize the natural and synthetic C1 assimilation pathways and their key factors for metabolizing C1 feedstock.Accordingly,we discussed the metabolic engineering strategies for enabling the microbial utilization of C1 feedstocks for the bioproduction of value-added chemicals.In addition,we highlighted future perspectives of C1-based biomanufacturing for achieving a low-carbon footprint for the biosynthesis of chemicals. | Jian Zhang Liang Guo Cong Gao Wei Song Jing Wu Liming Liu Xiulai Chen | 2023 | Systems Microbiology and Biomanufacturing2023，3，1： | 0 |
| 19 | Metabolic engineering strategies for microbial utilization of methanol显示文摘The increasing shortage of fossil resources and environmental pollution has renewed interest in the synthesis of value-added biochemicals from methanol.However,most of native or synthetic methylotrophs are unable to assimilate methanol at a sufficient rate to produce biochemicals.Thus,the performance of methylotrophs still needs to be optimized to meet the demands of industrial applications.In this review,we provide an in-depth discussion on the properties of natural and synthetic methylotrophs,and summarize the natural and synthetic methanol assimilation pathways.Further,we discuss metabolic engineering strategies for enabling microbial utilization of methanol for the bioproduction of value-added chemicals.Finally,we highlight the potential of microbial engineering for methanol assimilation and offer guidance for achieving a low-carbon footprint for the biosynthesis of chemicals. | Yamei Gan Xin Meng Cong Gao Wei Song Liming Liu Xiulai Chen | 2023 | Engineering Microbiology2023，3，3： | 0 |
| 20 | Perovskite solar cells with NiO_(x) hole-transport layer显示文摘Inverted perovskite solar cells(PSCs)have attracted interest due to their simple fabrication,long-term stability,and small hysteresis[1-3].It is noteworthy that the quality of the hole-transport layer(HTL)largely determines the device performance.Nickel oxide(NiO_(x))has been paid great attention as a hole-transport material in PSCs because of its natural p-type property,low cost,good stability,and high transmittance[4,5]. | Mengjia Li Zuolin Zhang Jie Sun Fan Liu Jiangzhao Chen Liming Ding Cong Chen | 2023 | Journal of Semiconductors2023，44，10： | 0 |
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