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| 1 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 2 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 2 |
| 3 | Evaluation of SWAT sub-daily runoff estimation at small agricultural watershed in Korea显示文摘A study was undertaken for the prediction of runoff flow from 0.8 ha field-sized agricultural watershed in South Korea using Soil and Water Assessment Tool (SWAT) sub-daily. The SWAT model with sub-daily configuration predicted flow from the watershed within the range of acceptable accuracy. The SWAT sub-daily simulations were carried out for a total of 18 rainfall events, 9 each for calibration and validation. Overall trend and extent of matching simulated flow for the rainfall events in 2007-2008 with measured data during the calibration process were coefficient of determination (R2) value of 0.88 and Nash and Sutcliffe Efficiency (ENs) value of 0.88. For validation, R2 and ENs values were 0.9 and 0.84, respectively. Whereas R2 and ENs values for simulation results using daily rainfall data were 0.79 and -0.01, respectively, that were observed to be out of acceptable limits for the model simulation. The importance of higher time resolution (hourly) precipitation records for flow simulation were evaluated by comparing Ra and ENs with 15 min, 2 h, 6 h and 12 h precipitation data, which resulted in lower statistics with increases in time resolution of precipitation data. The SWAT sub-daily sensitivity analysis was performed with the consideration of hydraulic parameter and was found as in the rank order of CN2 (curve number), ESCO (soil evaporation compensation factor), GW_DELAY (ground water delay time), ALPHA BF (base flow alpha factor), GWQMN (a threshold-minimum depth of water in the shallow aquifer required for return flow to occur), REVAPMN (minimum depth of water in shallow aquifer for re-evaporation to occur), LAT TIME (lateral flow travel time) respectively. These sensit]-ve parameters were evaluated at 10% higher and lower values of the parameters, corresponding to 70.5% higher and 23.2% lower in simulated flow out from the SWAT model. From the results obtained in this study, hourly precipitation record for SWAT sub-daily with Green-Ampt infiltration method was proven to be efficient for runoff estimation at field sized watershed with higher accuracies that could be efficiently used to develop site- specific Best Management Practices (BMPs) considering rainfall intensity, rather than simply using daily rainfall data. | Ganga Ram Maharjan Youn Shik Park Nam Won Kim Dong Seok Shin Jae Wan Choi Geun Woo Hyun Ji-Hong Jeon Yong Sik Ok Kyoung Jae Lim | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 6 | Electrospinning of polysaccharides for regenerative medicine显示文摘 | Kuen Yong Lee Lim Jeong Yun Ok Kang | 2009 | Advanced Drug Delivery Reviews2009，61，： | 1 |
| 7 | Effect of Ca addition on the microstructure and mechanical properties of heat-treated Mg-6.0Zn-1.2Y-0.7Zr alloy显示文摘In this study,the effects of Ca addition on the microstructure,thermal properties,and mechanical properties of a Mg-6.0Zn-1.2Y-0.7Zr(ZWK611)alloy at room temperature and 150℃ were investigated.With an increase in the Ca content,the ignition resistance of the ZWK611 alloy improved and the grains became finer.The as-cast ZWK611 alloy consisted mainly of the dendriticα-Mg matrix and I-phase(Mg_(3)Zn_(6)Y)at the grain boundaries.On the other hand,theτ-(Ca_(2)Mg_(6)Zn_(3))and I-phases were formed in the Ca-added ZWK611 alloy.The fraction of theτ-phase increased with an increase in the Ca content.After the solid-solution treatment,these phases remained partially at the grain boundaries of the Ca-added ZWK611 alloys and an additional W-phase(Mg_(3)Zn_(3)Y)was observed.The phases remaining at the grain boundaries restricted the grain growth through the grain boundary pinning effect.The aging treatment resulted in the formation of MgZn'precipitates in theα-Mg matrix of the alloys.These precipitates were more uniformly distributed in the Ca-added alloys than in the alloys without Ca.Thus,the heat treatment-induced precipitation improved the tensile and creep properties of the T6-treated alloys.The T6-treated ZWK611+0.7Ca alloy exhibited the best mechanical properties at room temperature and 150℃ among all the tested alloys. | Young Gil Jung Wonseok Yang Yong Joo Kim Shae.K.Kim Young Ok Yoon Hyunkyu Lim Do Hyang Kim | 2021 | Journal of Magnesium and Alloys2021，9，5： | 1 |
| 8 | Computational modeling with fluid-structure interaction of the severe m1 stenosis before and after stenting显示文摘 | Park S Lee SW Lim OK | 2013 | Neurointervention2013，8，1： | 1 |
| 9 | SLIPA? may be more useful than other LMADs for difficult airway management显示文摘 | Byung Gun Lim Kyung Jong Kim Myoung Hoon Kong Nan Suk Kim Sang Ho Lim Mi Kyoung Lee Il Ok Lee | 2012 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2012，，1： | 1 |
| 10 | Effects of natural and calcined oyster shells on Cd and Pb immobilization in contaminated soils 显示文摘 | OK Y S OH S E AHMAD M HYUN S KIM K R MOON D H LEE S S LIM K J JEON W T YANG J E | 2010 | Environmental Earth Sciences2010，61，6： | 1 |
| 11 | Management and Outcome of Gastrointestinal Stromal Tumors of the Duodenum显示文摘 | Jun Chul Chung Chong Woo Chu Gyu Seok Cho Eung Jin Shin Chul Wan Lim Hyung Chul Kim Ok Pyung Song | 2010 | Journal of Gastrointestinal Surgery2010，，5： | 1 |
| 12 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 1 |
| 13 | Overexpression of Protein Phosphatase Non-receptor Type 11 (PTPN11) in Gastric Carcinomas显示文摘 | Jin Soo Kim Ok Ran Shin Hyung Keun Kim Young Seok Cho Chang Hyeok An Keun Woo Lim Sung Soo Kim | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 14 | Reclassification of Bacillus haloalkaliphilus Fritze 1996 as Alkalibacillus haloalkaliphilus gen nov, comb nov and the description of Alkalibocillus salilacus sp nov, a novelhalophilic bacterium isolated from a salt lake in China显示文摘 | Che Ok Jeon Jee-Min Lim Jung-Min Lee | 2005 | Int J Syst Evol Microbiol2005，55，： | 1 |
| 15 | Thermal characteristics of organoclay and their effects upon the formation of polypropylene/organoclay nanocomposites显示文摘 | Jin Woo Lee Yong Taik Lim O Ok Park | 2000 | Polymer Bulletin2000，45，： | 1 |
| 16 | Ca对AlMg5合金均匀化过程中热压缩行为和微观结构稳定性的影响(英文)显示文摘研究微量Ca添加对AlMg5热变形过程中微观结构稳定性和动态回复行为的影响。研究手段包括扫描电子显微术(SEM)、差示扫描量热法(DSC)、电子背散射衍射(EBSD)分析和透射电子显微术(TEM)。利用JMatPro程序包对合金的凝固路径进行模拟。结果表明,Ca的加入对铸态试样的显微组织和热压缩行为没有影响,但能阻止均匀化过程中晶粒的急剧长大。在热压缩过程中,无Ca合金中的粗晶粒促进合金的动态回复,减缓动态再结晶,其再结晶晶粒的主要形核机制是粒子激发形核。另一方面,热压缩含Ca合金的显微组织受到Al4Ca金属间化合物的显著影响。通过JMatPro预测,并通过DSC、SEM和TEM揭示Al4Ca相的形成。最后,在含Ca合金的晶界处发现Al4Ca析出相通过Zener钉扎效应阻碍α(Al)相的增长,提高均匀化过程中微观结构的稳定性。 | Bong Huang KIM Majid SEYED SALEHI Ashkan NOURI Mohammad Sadegh MOHEBI Seong Ho HA Young Ok YOON Hyun Kyu LIM Shae KKIM BGhasem EISAABADI | 2020 | Transactions of Nonferrous Metals Society of China2020，30，3： | 1 |
| 17 | Improved electrorheological effect in polyaniline nanocomposite sus- pensions显示文摘 | Yong Talk Lim Jong Hyeok Park O Ok Park | 2002 | J Colloid Interface Sci2002，245，： | 1 |
| 18 | The fabrication of syndiotactic polystyrene/organophilic clay nanocomposites and their properties 显示文摘 | Cheon H P Park O Ok Jae Gon Lim | 2001 | Polym2001，42，： | 1 |
| 19 | Sensory based walking motion instruction for biped humanoid robot显示文摘 | Yu Ogura Shumpei Ando Hun ok Lim | 2004 | Robotics and Autonomous Systems2004，48，4： | 1 |
| 20 | Downregulation of cell‐free miR‐198 as a diagnostic biomarker for lung adenocarcinoma‐associated malignant pleural effusion显示文摘 | Hye‐Suk Han Jieun Yun Sung‐nam Lim Joung‐Ho Han Ki Hyeong Lee Seung Taik Kim Min‐Ho Kang Seung‐Myoung Son Yong‐Moon Lee Song‐Yi Choi Seok Joong Yun Wun‐Jae Kim Ok‐Jun Lee | 2013 | Int. J. Cancer2013，，3： | 1 |
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