| 1 | Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats显示文摘OBJECTIVE: To assess toxicities of the air in Chi-nese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products(MBP).METHODS: Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats(n = 16/group, male: female =1∶1) were exposed to five different concentrations(95%, 90%, 85%, 80% and 75%, respectively) of MBP for 2 h. For the chronic toxicity study, another three groups of male rats(n = 21/group) were exposed to MBP in three concentrations(10%, 40%and 70%, respectively) and one control group exposed to clean air 20 min/d for 144 d. Routine examinations were performed and analyzed by analysis of variance and dose-response relationship.RESULTS: In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75%groups were 16, 13, 7, 6 and 3, respectively, with LD50 of 86.274% after or during the 2 h exposure.In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights(P < 0.05) and lung. Rats in the70% MBP group also presented with reversible damage in the blood coagulation system(P < 0.05).CONCLUSION: Exposure to 10% MBP, which is equivalent to 27.45 mg/m3, was under the critical threshold for male rats' safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation. | Han Li Liu Changxi Liu Ping Hu Hai Yang Jia Cai Hong Lim Minyee Zhu Maoxiang Pan Xiujie Huang Jian Cui Yingxue Lao Lixing Zhao Baixiao | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 2 | Twelve-week study of moxa smoke: occupational exposure in female rats显示文摘OBJECTIVE: To assess the toxicity of moxa smoke in rats.METHODS: Forty-eight female Wister rats were randomly divided into 4 groups(n = 12/group) to simulate moxa smoke exposure in Chinese medicine clinics(CMCs): the control group, and three moxa-smoke exposed groups of PM10 mass concentrations 3-5, 7-9 and 27-30 mg/m^3, respectively.These concentrations were 1 ×, 2-3 ×, and 7-9 ×fold the concentrations found in CMCs. Exposures continued for 12 weeks(200 min/d, 5 d/week).RESULTS: No deaths were noted. After the exposure, the body weights, ratios of organ weight to body weight, urinary parameters, hematological parameters, clinical chemistry parameters and microscopic examinations revealed no obvious toxicity.CONCLUSION: Moxa smoke did not induce toxic effects in female rats in the study. These findings provide new evidence to the toxicity of moxa smoke. | Han Li Huang Chang Yang Jia Wang Lei Bai Hua Liu Juntian Jian Huang Liu Ping Lim MinYee Ju Dahong Lao Lixing Liu Changxi Zhao Baixiao Sun Wen Xu Anping Yang Xiuyan Zhang Cong He Rui | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 0 |
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