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| 1 | ABA Signaling in Guard Cells Entails a Dynamic Protein-Protein Interaction Relay from the PYL-RCAR Family Receptors to Ion Channels显示文摘植物荷尔蒙 abscisic 酸(骆驼毛的织物) 用作象干旱那样的环境压力的一个综合者由在警卫房间调整特定的离子隧道触发有气孔的闭合。我们以前报导了那 SLAC1,为有气孔的闭合要求的一条外面的阴离子隧道,经由包含表明部件,包括的蛋白质磷酸酶 2C 成员和 SnRK2 类型 kinase (OST1 ) 的骆驼毛的织物的可逆蛋白质 phosphorylation 事件被调整。在这研究,我们重新组成从 PYL/RCAR-type 受体作为一个 proteinprotein 相互作用继电器表明小径的 ABA 到 PP2CSnRK2 phosphatasekinase 对,到离子隧道 SLAC1。骆驼毛的织物受体交往了与并且对 SnRK2 类型 kinase 禁止了 PP2C 磷酸酶活动,导致减少的警卫房间 turgor 和有气孔的闭合,释放活跃 SnRK2 kinase phosphorylate,并且激活 SLAC1 隧道。二混血儿的酵母和双分子的荧光互补试金被用来在小径在部件之中验证相互作用。这些生物化学的试金由他们的相互作用搭挡表明了磷酸酶和 kinases 的活动修正。SLAC1 隧道活动为发信号的小径的力量被用作端点读出,取决于表明部件的不同联合的存在。用 ABA 受体之一表明了那个变化的转基因的植物 overexpressing 的进一步的学习交往的搭挡的相对水平将变化骆驼毛的织物敏感。 | Sung Chul Lee Chae Woo Lim Wenzhi Lan Kai He Sheng Luan | 2013 | Molecular Plant2013，6，2： | 7 |
| 2 | A topologically substituted boron nitride hybrid aerogel for highly selective CO2 uptake显示文摘A topologically mediated synthesis of porous boron nitride aerogel has been experimentally and theoretically investigated for carbon dioxide (CO2)uptake. Replacement of the carbon atoms in a precursor aerogel of graphene oxide and carbon nanotubes was achieved using an elemental substitution reaction,to obtain a boron and nitrogen framework.The newly prepared BN aerogel possessed a specific surface area of 716.56m^2/g and exhibited an unprecedented twenty- fold increase in CO2uptake over N2,adsorbing 100cc/g at 273K and 80cc/g in ambient conditions,as verified by adsorption isotherms via the multipoint Brunauer-Emmett-Teller (BET)method.Density functional theory calculations were performed to give hints on the mechanism of such high selectivity of CO2 over N2adsorption in BN aerogel,which may be due to the interaction between the intrinsic polar nature of B-N bonds and the high quadrupole moment of CO2 over N2. | R.Govindan Kutty Sivaramapanicker Sreejith Xianghua Kong Haiyong He Hong Wang Junhao Lin Kazu Suenaga Chwee Teck Lim Yanli Zhao Wei Ji Zheng Liu | 2018 | Nano Research2018，11，12： | 5 |
| 3 | Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice显示文摘Cre/lox P technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmp1-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmp1-Cre in the gastrointestinal mesenchyme, deletion of Bmpr1 a with Dmp1-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling.Thus, caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types. | Joohyun Lim Joseph Burclaff Guangxu He Jason C Mills Fanxin Long | 2017 | Bone Research2017，5，1： | 4 |
| 4 | Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth显示文摘Bone morphogenetic proteins(Bmp) are well-known to induce bone formation following chondrogenesis,but the direct role of Bmp signaling in the osteoblast lineage is not completely understood. We have recently shown that deletion of the receptor Bmpr1 a in the osteoblast lineage with Dmp1-Cre reduces osteoblast activity in general but stimulates proliferation of preosteoblasts specifically in the cancellous bone region,resulting in diminished periosteal bone growth juxtaposed with excessive cancellous bone formation.Because expression of sclerostin(SOST), a secreted Wnt antagonist, is notably reduced in the Bmpr1 adeficient osteocytes, we have genetically tested the hypothesis that increased Wnt signaling might mediate the increase in cancellous bone formation in response to Bmpr1 a deletion. Forced expression of human SOST from a Dmp1 promoter fragment partially rescues preosteoblast hyperproliferation and cancellous bone overgrowth in the Bmpr1 a mutant mice, demonstrating functional interaction between Bmp and Wnt signaling in the cancellous bone compartment. To test whether increased Wnt signaling can compensate for the defect in periosteal growth caused by Bmpr1 a deletion, we have generated compound mutants harboring a hyperactive mutation(A214 V) in the Wnt receptor Lrp5. However, the mutant Lrp5 does not restore periosteal bone growth in the Bmpr1 a-deficient mice. Thus, Bmp signaling restricts cancellous bone accrual partly through induction of SOST that limits preosteoblast proliferation, but promotes periosteal bone growth apparently independently of Wnt activation. | Guangxu He Yu Shi Joohyun Lim Teresita Bellido Jiangdong Ni Fanxin Long | 2017 | Bone Research2017，5，3： | 3 |
| 5 | Tribological properties of short carbon fibers reinforced epoxy composites显示文摘Short carbon fiber(SCF)reinforced epoxy composites with different SCF contents were developed to investigate their tribological properties.The friction coefficient and wear of the epoxy composites slid in a circular path against a steel pin inclined at 45°to a vertical axis and a steel ball significantly decreased with increased SCF content due to the solid lubricating effect of SCFs along with the improved mechanical strength of the composites.The scanning electron microscope(SEM)observation showed that the epoxy composites had less sensitive to surface fatigue caused by the repeated sliding of the counterparts than the epoxy.The tribological results clearly showed that the incorporation of SCFs was an effective way to improve the tribological properties of the epoxy composites. | Nay Win KHUN He ZHANG Lee Hoon LIM Chee Yoon YUE Xiao HU Jinglei YANG | 2014 | Friction2014，2，3： | 2 |
| 6 | Impact of obstructive sleep apnea on the atri- al electromechanical activation time 显示文摘 | Lim HE Kim YH Kim SH | 2009 | Circ J2009，73，2： | 1 |
| 7 | A microRNA component of the p53 tumour suppressor network显示文摘 | He L He X Lim L P | 2007 | Nature2007，447，7148： | 1 |
| 8 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 9 | Clinical value of serum uric acidin patients with suspected coronary artery disease显示文摘 | Lim HE Kim SH Kim EJ | 2010 | Korean J In-tern Med2010，25，1： | 1 |
| 10 | Size-dependent nonlinear response of thin elastic films with nano-scale thickness 显示文摘 | Lim C W He L H | 2004 | International Journal of Mechanical Sciences2004，46，： | 1 |
| 11 | Comparison and appli- cation of three integral -improved methods on conven- tional fuzzy control strategy 显示文摘 | He Y B Lim G H Chua P S K | 2003 | Engineering Applications of Artificial Intelligence2003，16，78： | 1 |
| 12 | Modem water hydraulics-the new energy transmission technology in fluid power显示文摘 | LIM GH CHUA P S K HE YB | 2003 | Applied Energy2003，76，： | 1 |
| 13 | Modem Water hydraulics-the new energy- transmission technology in fluid power显示文摘 | Lim G H Chua P S K He Y B | 2003 | Applied Energy2003，76，： | 1 |
| 14 | A microRNA component of the p53 tumour suppressor network显示文摘 | He L He X Lim LP | 2007 | Nature2007，447，7148： | 1 |
| 15 | On the bending of unconstrained thin ctystalline plates caused by the change insurface stress显示文摘 | He L H Lim C W | 2001 | Sur Sci2001，478，3： | 1 |
| 16 | A microRNA component of the p53 tumour suppressor network显示文摘 | He L He X Lim LP | 2007 | Nature2007，447，7148： | 1 |
| 17 | Size dependent, non- uniform elastic field inside a nano-scale spherical inclusion due to interface stress显示文摘 | Lim C W Li Z R He L H | 2006 | International Journal of Solids and Structures2006，43，50： | 1 |
| 18 | A microRNA component of the p53 tumour suppressor network显示文摘 | He L He X Lim L P etal | 2007 | Nature2007，447，7148： | 1 |
| 19 | Mass mortalities associated with viral nervous necrosis in harchery-reared groupers in the People's Republic of China显示文摘 | Lim R He J G Mori K | 2001 | Fish Pathology2001，36，： | 1 |
| 20 | Exact solution of a compositionally graded piezoelectric layer under uniform stretch, bending and twisting显示文摘 | Lim C W He L H | 2001 | I J of Meehanioal Science2001，43，11： | 1 |
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