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| 1 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 2 | Human endogenous retroviral syncytin exerts inhibitory effect on invasive phenotype of B16F10 melanoma cells显示文摘Objective:Fusogenic endogenous retroviral syncytin plays an important role in the formation of syncytiotrophoblasts in human placenta.Apart from its expression in placenta,brain and testis,syncytin has also been found in many cancers.Although syncytin has been proposed to serve as a positive prognostic marker in some cancers,the underlying mechanism is unclear.The aim of this study is to evaluate the effects of syncytin expression on the invasive phenotype of melanoma cells.Methods:The eukaryotic expression plasmid for syncytin-EGFP was constructed and transfected into B16F10 melanoma cells.The effect of syncytin on the invasion potential of tumor cells was evaluated in B16F10 subline cells that stably expressed syncytin-EGFP fusion protein or EGFP alone.Results:The B16F10 sublines that stably expressed syncytin-EGFP or EGFP alone were established respectively and confirmed by immunofluorescent and immunoblotting assay.Syncytin expression in B16F10cells was associated with decreased cell proliferation,migration and invasion.Multinucleated giant cells that contained as many as five nuclei were induced in syncytin-expressing cells.In addition,syncytin expression did not alter the sensitivity of B16F10 cells to trichosanthin,a toxin that damages syncytiotrophoblasts more efficiently than other tissues.Conclusions:These results suggest that syncytin expression in some cancers may confine their invasion potential and thus serve as a positive prognostic factor. | Hongbo Mo Dongyun Ouyang Lihui Xu Qi Gao Xianhui He | 2013 | Chinese Journal of Cancer Research2013，25，5： | 3 |
| 3 | A process study of electron beam nano-lithography and deep etching with an ICP system显示文摘A systemic process study on an electron beam nanolithography system operating at 100kV was pre-sent.The exposure conditions were optimized for resist ZEP520A.Grating structures with line/space of 50nm/50nm were obtained in a reasonably thick resist which is beneficial to the subsequent pattern transfer technique.The ICP etching process conditions was optimized.The role of etching parameters such as source power,gas pressure,and gas flow rate on the etching result was also discussed.A grating structure with line widths as small as 100nm,duty cycles of 0.5,depth of 900nm,and the side-wall scalloping as small as 5nm on a silicon substrate was obtained.The silicon deep etching technique for structure sizes smaller than 100nm is very important for the fabrication of nano-optical devices working in the visible regime. | LI QunQing ZHANG LiHui CHEN Mo FAN ShouShan | 2009 | Science China(Technological Sciences)2009，52，6： | 2 |
| 4 | The air-borne particulate pollution in Beijing—concentration, composition, distribution and sources显示文摘 | Yele Sun Guoshun Zhuang Ying Wang Lihui Han Jinghua Guo Mo Dan Wenjie Zhang Zifa Wang Zhengping Hao | 2004 | Atmospheric Environment2004，，35： | 2 |
| 5 | The air-borne particulate pollution in Beijing—concentration, composition, distribution and sources显示文摘 | Yele Sun Guoshun Zhuang Ying Wang Lihui Han Jinghua Guo Mo Dan Wenjie Zhang Zifa Wang Zhengping Hao | 2004 | Atmospheric Environment2004，，35： | 1 |
| 6 | Plant Community Diversity in Dongtian Forest Park,Meizhou City,South China显示文摘Dongtian Park is a forest park in Dongtian Lake Ecological Tourism Resort in Meizhou City,South China.Through investigation and analysis of sample methods of the forest community structure and plant diversity in this park,the results showed that there were 181 plant species,belonging to 138 genera in 76 families,including 48 trees,60 shrubs,36 herbs and 37 lianas.The flora is a subtropical evergreen broad-leaved forest with some distinct tropical properties,and evergreen trees accounted for 48.62%of total plant species.The dominant species in the tree layer were Schima superba,Pinus massoniana,Cinnamomum parthenoxylon,etc.,and those in the shrub layer were Bambusa textilis,Aidia cochinchinensis,Rhaphiolepis indica,etc.,and in herb layer were Carex baccans,Adiantum flabellulatum,Cibotium barometz,etc.,and the lianas mainly included Smilax hypoglauca,Callerya dielsiana,Trachelospermum jasminoides,etc.There were few adults of dominant species in the tree layer,S.superba and P.massoniana also lacked seedlings,they would still maintain their dominant position for a quite long period,but Cyclobalanopsis neglecta had sufficient seedling reserves and would be most likely to become a dominant species in future.The community had relatively rich species,many ferns and lianas and complex hierarchy.The evenness,Shannon-Wiener diversity,Pielou uniformity and Simpson index were higher in the shrub layer than in the tree and herb layer,and the Simpson index was the lowest(0.9280)in the herb layer and Shannon-Wiener diversity index was the highest(7.5853)in the liana layer. | Qihe YANG Zhiqi LI Hesheng YANG Lihui MO | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
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