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| 1 | Small molecules for fat combustion: targeting obesity显示文摘Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches,either pancreatic lipase inhibitors or appetite suppressors, are generally of limited effectiveness. Brown adipose tissue(BAT) and beige cells dissipate fatty acids as heat to maintain body temperature, termed non-shivering thermogenesis; the activity and mass of BAT and beige cells are negatively correlated with overweight and obesity. The existence of BAT and beige cells in human adults provides an effective weight reduction therapy, a process likely to be amenable to pharmacological intervention. Herein, we combed through the physiology of thermogenesis and the role of BAT and beige cells in combating with obesity. We summarized the thermogenic regulators identified in the past decades, targeting G proteincoupled receptors, transient receptor potential channels, nuclear receptors and miscellaneous pathways.Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of thermogenesis in energy homeostasis to the representative thermogenic regulators for treating obesity. Thermogenic regulatorsmight have a large potential for further investigations to be developed as lead compounds in fighting obesity. | Jingxin Liu Yitao Wang Ligen Lin | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Numerical investigation on effects of side curtain opening behavior on indoor climate of naturally ventilated dairy buildings显示文摘The side-curtain is popular in cattle buildings to regulate indoor climates and ventilation rates by adjusting the opening ratio.It normally had three different adjusting strategies relate to the position of rollers,i.e.central roller(S1),top roller(S2)and bottom roller(S3),which result in different opening behaviors to generate the same opening ratio but different opening positions in the side wall for a full-curtain house.Numerical simulations were conducted using computational fluid dynamics(CFD)to investigate the effects of the eight potential opening behaviors of side curtains on the indoor climates and airflow rates in winter for a typical naturally ventilated dairy house in China when the opening ratio were 8.5%and 17%.Airflow patterns,wind chilled temperature(WCT)and age of air were analyzed in the animal occupied zone(AOZ)by taking reference planes.Openings at the very bottom of side walls had more efficient ventilation due to the younger air age,more effective air disturbing,more uniformly distributed indicators in AOZ.However,it will result in a lower WCT in AOZ although a lower ventilation rate was observed in this case.Openings on the very top of side wall would generate a better thermal comfort in AOZ but with very poor air quality and nonuniformly distributed airflows in the dairy house.S1 was not recommended to the practical application due to the poor indoor climate and the higher cost of the mechanical structure.Based on the comprehensive evaluations of the analytic hierarchy process,the most satisfaction opening positions were at the bottom of the side curtains and the optimized adjusting strategy is S2. | Qifeng Li Chuanxia Yao Luyu Ding Ligen Yu Weihong Ma Ronghua Gao Wengang Zheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 3 | Single-atom Sn-Zn pairs in CuO catalyst promote dimethyldichlorosilane synthesis显示文摘Single-atom catalysts are of great interest because they can maximize the atom-utilization efficiency and generate unique catalytic properties;however,much attention has been paid to single-site active components,rarely to catalyst promoters.Promoters can significantly affect the activity and selectivity of a catalyst,even at their low concentrations in catalysts.In this work,we designed and synthesized CuO catalysts with atomically dispersed co-promoters of Sn and Zn.When used as the catalyst in the Rochow reaction for the synthesis of dimethyldichlorosilane,this catalyst exhibited much-enhanced activity,selectivity and stability compared with the conventional CuO catalysts with promoters in the form of nanoparticles.Density functional theory calculations demonstrate that single-atomic Sn substitution in the CuO surface can enrich surface Cu vacancies and promote dispersion of Zn to its atomic levels.Sn and Zn single sites as the co-promoters cooperatively generate electronic interaction with the CuO support,which further facilitates the adsorption of the reactant molecules on the surface,thereby leading to the superior catalytic performance. | Qi Shi Yongjun Ji Wenxin Chen Yongxia Zhu Jing Li Hezhi Liu Zhi Li Shubo Tian Ligen Wang Ziyi Zhong Limin Wang Jianmin Ma Yadong Li Fabing Su | 2020 | National Science Review2020，7，3： | 2 |
| 4 | Differentiation characteristics and influencing factors of ecological land rent among provinces in China显示文摘生态的陆地租金是资源缺乏生产的过量利润,并且也是为测量资源缺乏的社会、经济的效果的重要指示物。这份报纸,由在中国计算所有省的各自的生态的陆地租金年 2002 和 2007,并且与软件程序 ArcGIS 和 GeoDA 的帮助,分析生态的陆地租金的空间区别特征;然后,在省之中的生态的陆地租金区别的影响因素用传统的回归和空间关联分析的方法被检验。下列结果被获得:首先,生态的陆地租金每在中国输出联合起来显示出在 Hebei 和河南省省在西南、东北的省,和高度是低的稳定的分发特征。也在东方省在中央、西方的省,和一个减少的省有一个增加的趋势。一般来说,生态的陆地租金的空间分发相当每在中国输出联合起来被散布。第二,全部的生态的陆地租金显示出重要空间聚集特征,,特别地在拥有生态的陆地租金的高全部的数量的中国的省趋于邻近对方与低全部的数量,和空间差别特征做那些东方,中央、西方的省被区分。Bohai 边界,长江三角洲和珀尔河三角洲被显示高度正在聚类全部的生态的陆地租金的区域,当西方的省以全部的数量有很低的生态的陆地租金时。第三,人口分发,经济水平和工业结构都是重要的影响在中国在省之中影响生态的陆地租金区别的因素。而且,人口密度,都市化水平,经济密度,人均的消费水平和 GDP 人均都被显示是断然与全部的生态的土地有关租租金和这些因素,它显示空间聚类在生态的土地之间存在。然而,也在生态的陆地租金和农业产量百分比之间有否定关联,显示空间散布在生态的陆地租金和农业产量百分比之间存在。 | LONG Kaisheng ZHAO Yali ZHANG Honghui CHEN Ligen LU Fangfang GU Yuanyuan | 2013 | Journal of Geographical Sciences2013，23，3： | 2 |
| 5 | Chemical characterization and radioprotective effect of polysaccharide from Monostroma angicava (Chlorophyta) 显示文摘 | Mao Wenjun Li Yi Wu Ligen | 2005 | Journal of Applied Phycology2005，17，： | 1 |
| 6 | Modification of the X-irradiation Syndrome by Lycopene显示文摘 | Forssberg A Ligen C Ernster L | 1959 | Exp Cell Res1959，16，： | 1 |
| 7 | Characterizing physiological N -use efficiency as influenced by nitrogen management in three rice cuhivars 显示文摘 | LIGEN JIANGA TINGBO DAI DONG JIANG | 2004 | Field Crops Research2004，，88： | 1 |
| 8 | Investigations of poly(pyrrole)-coated cotton fabrics prepared in blends of anionic and cationic surfacants as flexible electrode显示文摘 | Liang Guijie Zhu Ligen Xu Jie | | 0，，： | 1 |
| 9 | Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius显示文摘To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction. | TANG Ligen ZHU Weiyao ZHU Huayin SUN Chunhui YANG Fenglai WANG Yan Li Xiaorui Li Haiming CHU Guangzhen WANG Jieming KONG Debin YUE Ming LIU Yuwei HUANG Kun | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 10 | Nitrogen and phosphorus concentrations from agrieultural catchments influence of spatial and temporal variables显示文摘 | Arheimer B Ligen R | 2000 | Journal of Hydrology2000，227，1： | 1 |
| 11 | Modification of the Xirradiation syndrome by lycopene显示文摘 | Forssberg A Ligen C Ernster L | 1959 | Exp Cell Res1959，16，： | 1 |
| 12 | Grey system model with the fractional order accu- mulation显示文摘 | Lifeng Wu Sifeng Liu Ligen Yao Shuli Yan Dinglin Liu | 2013 | Communications in Nonlinear Science and Numerical Simulation2013，18，7： | 1 |
| 13 | Grey system model with the fractional order accumulation 显示文摘 | Lifeng Wu Sifeng Liu Ligen Yao Shuli Yah Dinglin Liu | 2013 | Commun Nonlinear Sci Numer Simulat2013，18，： | 1 |
| 14 | Grey system model with the fractional order accumulation显示文摘 | Wu Lifeng Liu Sifeng Yao Ligen | 2013 | Communications in nonlinear science and numerical simulation2013，18，： | 1 |
| 15 | Study on Preparation Process of Effervescent Tablets Made from EGCG of Tea显示文摘[Objective] The study aimed to discuss the preparation process of Epigallocatechin-3-gallate (EGCG) effervescent tablets. [Method] Various raw materials were dried for different time at 50 ℃, and then the sticking degree of EGCG effervescent tablets was reviewed. Hereafter, the formula of EGCG effervescent tablets was optimized by orthogonal test. [Result] Effervescent tablets without sticking were smooth after being dried for 150 min. The optimal formula of EGCG effervescent tablets was composed of 4% EGCG, 45% citric acid and sodium carbonate (Citric acid∶Sodium carbonate = 1.6∶1), 20% lactose, 4% L-leucine, 4% sodium cyclamate and 23% orange powder. [Conclusion] The prepared EGCG effervescent tablets without sticking has a good effervescence effect and taste. | WANG Xianbo ZOU Ligen QIAN Lihua ZHAO Yun | 2012 | Chinese Food Science2012，1，4： | 1 |
| 16 | Repair and reconstruction of massively damaged burn wounds显示文摘 | Jiake Chai Huifeng Song Zhiyong Sheng Baoju Chen Hongming Yang Ligen Li | 2003 | Burns2003，，： | 1 |
| 17 | 显示文摘 | OUYANGPan(欧阳攀) ZHANGHong(张鸿) LIGen(李根) eta1 | 2012 | 电子元器件及材料2012，6，31： | 1 |
| 18 | Differential sensitivity of two green algae,Scenedesmns obliqnus and Chlorella pyrenoidosa,to 12 pesticides显示文摘 | Ma Jianyi Zheng Rongquan Xu Ligen | 2002 | Ecotoxicology and Environmental Safety2002，52，： | 1 |
| 19 | Magnetic resonance imaging features of soft tissue and vascular injuries after high-voltage electrical burns and their clinical application显示文摘 | Ligen L Hongming Y Feng L | | 0，，09： | 1 |
| 20 | Synthesis and shape memory behavior study of hyperbranched poly(urethane-tetrazole)显示文摘A novel hyperbranched poly(urethane-tetrazole)(HPUTZ) was synthesized via the 'A2+BB2' ' approach using hexadiisocyanate(HDI) and 3-(bis-(2-hydroxyethyl)) aminopropyltetrazole(HAPTZ).The molecular structure was characterized by FTIR and 1H NMR spectroscopy.The number average molecular weight was measured to be 1.05×104 g/mol with a polydispersity of 1.27 by GPC analysis.The HPUTZ was further cured by the semi-adduct(PEG-IPDI) from polyethylene glycol(PEG) reacting with isophorone diisocyanate(IPDI) to form the crosslinked HAPTZ-PU film in different ratio of HAPTZ to PEG-IPDI.The glass transition temperature of HAPTZ-PU increased from 44.9 to 56.4 ℃ as the HPUTZ content increased from 20% to 33% from the DSC analysis.The DMA results indicated that the HPUTZ-PU with 20% HPUTZ possessed the highest storage modulus and loss tangent.However,the storage modulus increased with the increasing of HPUTZ segment at higher temperature.The shape memory study showed that all the films presented the excellent shape memory function.Over 98% shape recovery could be obtained for the HAPTZ-PU with 20%-33% HAPTZ segment content within 60 s in the tension deformation test and within 40 s at 80 ℃ in the bend deformation test. | QIAO LiGen ASIF Anila SHI WenFang | 2011 | Science China Chemistry2011，54，9： | 1 |
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