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| 1 | Nanotwinned and hierarchical nanotwinned metals:a review of experimental,computational and theoretical efforts显示文摘The recent studies on nanotwinned(NT)and hierarchical nanotwinned(HNT)face-centered cubic(FCC)metals are presented in this review.The HNT structures have been supposed as a kind of novel structure to bring about higher strength/ductility than NT counterparts in crystalline materials.We primarily focus on the recent developments of the experimental,atomistic and theoretical studies on the NT and HNT structures in the metallic materials.Some advanced bottom-up and top-down techniques for the fabrication of NT and HNT structures are introduced.The deformation induced HNT structures are available by virtue of severe plastic deformation(SPD)based techniques while the synthesis of growth HNT structures is so far almost unavailable.In addition,some representative molecular dynamics(MD)studies on the NT and HNT FCC metals unveil that the nanoscale effects such as twin spacing,grain size and plastic anisotropy greatly alter the performance of NT and HNT metals.The HNT structures may initiate unique phenomena in comparison with the NT ones.Furthermore,based on the phenomena and mechanisms revealed by experimental and MD simulation observations,a series of theoretical models have been proposed.They are effective to describe the mechanical behaviors of NT and HNT metals within the applicable scope.So far the development of manufacturing technologies of HNT structures,as well as the studies on the effects of HNT structures on the properties of metals are still in its infancy.Further exploration is required to promote the design of advanced materials. | Ligang Sun Xiaoqiao He Jian Lu | 2018 | npj Computational Materials2018，，1： | 14 |
| 2 | A comparison between acute large vessel occlusion in the posterior circulation and anterior circulation after endovascular treatment:the ANGEL-ACT registry experience显示文摘Background and purpose Endovascular treatment(EVT)has shown an overwhelming benefit for acute anterior circulation artery occlusion(ACO).Whether it can achieve the same outcomes in posterior circulation artery occlusion(PCO)has not been well explained.We aimed to evaluate the characteristics and prognosis of ACO and PCO after EVT in a nationwide registry.Method The present analysis was based on the prospective ANGEL-ACT Registry in China between November 2017 and March 2019.Demographic data,periprocedural times,recanalisation rate,intracranial haemorrhage(ICH)and 90-day functional outcomes were compared between the ACO and PCO groups.Results A total of 1793 patients were analysed including 397(22.1%)consecutive patients with PCO and 1396(77.9%)patients with ACO treated with EVT.A larger proportion of patients with PCO had intracranial atherosclerotic disease and received extra angioplasty during EVT.Successful recanalisation and 90-day favourable functional outcomes did not differ significantly between the two groups.Patients with PCO showed lower 24-hour ICH and symptomatic ICH rates.There was a trend towards higher mortality rate in the PCO group(22.09%vs 14.44%;adjusted OR 1.286(95%CI 0.820 to 2.017),p=0.2731),especially when the onset to puncture time was over 6 hours(30.77%vs 11.13%;adjusted OR 2.673(95%CI 1.280 to 5.583),p=0.0089,interactive p=0.0002).Conclusions In this large prospective multicentre registry,there was a significant difference in the characteristics and periprocedural features between patients with PCO and ACO.However,successful recanalisation and 90-day favourable functional outcomes in PCO were equivalent to those in ACO. | Xuan Sun Jingyu Zhang Xu Tong Baixue Jia Dapeng Mo Ning Ma Feng Gao Lian Liu Xiaochuan Huo Ligang Song Yiming Deng Zhongrong Miao | 2022 | Stroke & Vascular Neurology2022，7，4： | 4 |
| 3 | Clinical characteristics and outcomes of Chinese patients with KRAS-mutant non-small cell lung cancer after chemotherapy显示文摘Dear Editor,The RAS gene is one of the most frequent oncogenes in human cancers,with significantly different mutation frequencies.The RAS family contains three isoforms:KRAS,HRAS and NRAS,with the KRAS mutations being more common than the other two.The KRAS mutation rate varies in non-small cell lung cancer(NSCLC)patients of different races:27%in Caucasians[1]and approximately 10%in Asians[2,3].Recently,the U.S.Food and Drug Administration(FDA)approved sotorasib(AMG510)and adagrasib(MRTX849)for the treatment of metastatic NSCLC harboring KRAS G12C mutations.In the face of novel treatment choices for KRAS-mutated NSCLC,it is indispensable to learn more about the systemic treatment of these patients.Clinical studies have shown that Caucasian patients with KRAS-mutated NSCLC had poor outcomes following first-line chemotherapy[4,5].However,studies on treatment outcomes of Asian patients with KRAS-mutated NSCLC are lacking.As the overwhelming majority of cases are diagnosed with lung adenocarcinoma,the standard first-line treatment for metastatic disease is pemetrexed-based doublet chemotherapy in combination with bevacizumab and/or immunotherapy in China.Herein,we investigated the clinical characteristics of KRAS mutation subtypes,co-occurring genomic alterations,and efficacy of first-line pemetrexed-platinum chemotherapy in Chinese KRAS-mutated NSCLC patients. | Yawen Zheng Qinghua Lai Hanxi Zhao Xiaolin Li Xiaorong Sun Ligang Xing | 2021 | Cancer Communications2021，41，11： | 4 |
| 4 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 5 | PdNi/N-doped graphene aerogel with over wide potential activity for formic acid electrooxidation显示文摘Anti-CO poisoning ability is significant in formic acid oxidation in the fuel cell technique.Herein,Pd Ni alloy supported on N-doped graphene aerogel(Pd Ni/GA-N)was found to have catalytic ability toward formic acid electrooxidation over a wide potential range because of the improved anti-CO poisoning ability.This catalyst was fabricated by simple freeze-drying of mixture solution of graphene aerogel,polyvinylpyrrolidone,Pd^(2+)and Ni^(2+)and the subsequent thermal annealing reduction approach in the N2/H2 atmosphere.Pd-Ni alloy particles anchored over the folding N-doped graphene surface with a porous hierarchical architecture structure in the 3 D directions.It showed the catalytic performance of its maximum mass activity of 836 m A mg^(-1)in a broad potential range(0.2-0.6 V)for formic acid oxidation.The CO stripping experiment demonstrated its largely improved anti-CO poisoning ability with the peak potential of 0.67 V,approximately 60 and 40 m V less compared to those of Pd/GA-N and Pd/C samples.The high anti-CO poisoning ability and strong electronic effect resulting from the interaction between the3 D GA-N support and the Pd-Ni alloy makes it a promising catalyst for application in direct formic acid fuel cells. | Yufei Bao Meng Zha Pengliang Sun Guangzhi Hu Ligang Feng | 2021 | Journal of Energy Chemistry2021，30，8： | 3 |
| 6 | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice显示文摘Flaxseed has displayed the potential beneficial as functional foods.However,most studies focused on effects of flaxseed extracts or ingredients in flaxseed.Besides,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still unknown.In the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks.The results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut microbiota.In conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice. | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun | 2022 | Food Science and Human Wellness2022，11，1： | 3 |
| 7 | Selective Introduction of Carbazole and Diphenylamine into Spirofluorenexanthene Core for Different Phosphorescent Hosts显示文摘Built on the spiro[fluorene-9,9'-xanthene] (SFX) core and two frequently-used hole-transporting groups such ascarbazole and diphenylamine, two SFX derivatives, namely SFXCz and SFXDPA, have been synthesized byone-step reaction for red, green and blue phosphorescent organic light-emitting devices (PHOLEDs). Though theproperties of these two groups are very similar, the devices based on SFXCz and SFXDPA exhibit distinct perfor-mances. In blue PHOLEDs, the device based on SFXCz exhibited much better performances than that based onSFXDPA. However, the latter was superior to the former in green and red PHOLEDs. And the red PHOLED basedon SFXDPA exhibited maximum current efficiency (CE) of 27.1 cdoA^-l, power efficiency (PE) of 25.01m·W^-1, andexternal quantum efficiency (EQE) of 15.0%. The results show that the introduction of diphenylamine group issuitable for constructing green and red host materials, whereas the introduction of carbazole group is suitable forconstructing blue host materials. | Mingli Sun Shouzhen Yue Hongtao Cao Changjin Ou Yan Qian Ting Wang Ligang Chen Yi Zhao Wei Huang | 2016 | Chinese Journal of Chemistry2016，34，8： | 3 |
| 8 | Metallomics in environmental and health related research:Current status and perspectives显示文摘Metals and metalloids play distinct roles in human health,either beneficial or toxic,depending on their concentrations and species.There is an increasing interest in metals uptake,trafficking,function,and exertion in microorganisms to maintain and advance human health.Metallomics,an emerging research area,focuses on elucidation of metals/metalloids location,distribution,speciation,and behavior in living organisms.This paper briefly summarized the recent progress on the methodology development of metallomics including various techniques,i.e.multiple dimensional liquid chromatography-inductively coupled plasma mass spectrometry(LC-ICPMS),gel electrophoresis-laser ablation-inductively coupled plasma mass spectrometry(GE-LA-ICPMS),synchrotron X-ray fluorescent spectroscopy(XFS),and the applications of metallomics in environmental and health care. | HU LiGang HE Bin WANG YuChuan JIANG GuiBin SUN HongZhe | 2013 | Chinese Science Bulletin2013，58，2： | 2 |
| 9 | Cobalt diselenide (001) surface with short-range Co-Co interaction triggering high-performance electrocatalytic oxygen evolution显示文摘Oxygen evolution reaction (OER) still suffers from the bottleneck in electrocatalytic water splitting. Herein, in virtue of volcano plots drawn by theoretical calculation, the (001) facet was screened as the superb facet of orthorhombic CoSe_(2) for OER. Afterwards, CoSe_(2)(001) nanosheets were synthesized and the exposure ratio of (001) facet is controllable with thermodynamics methods effectively. The single-facet CoSe2(001) delivered an overpotential as low as 240 mV at 10 mA·cm^(−2) in 1 M KOH, which outperformed the bulk (380 mV) as well as other CoSe_(2)-base OER catalysts reported before. Especially, a shorter Co-Co path was observed in CoSe_(2)(001) by X-ray absorption spectroscopy. Further density functional theory (DFT) studies revealed that the reversible compression on the shorter Co-Co path could regulate the electronic structure of active sites during the OER process, and thus the energy barrier of the rate-determining step was reduced by 0.15 eV. This work could inspire more insights on the modification of electronic structure for OER electrocatalysts. | Kun Dang Shihao Zhang Xuewei Wang Wenming Sun Ligang Wang Yang Tian Sihui Zhan | 2021 | Nano Research2021，14，12： | 2 |
| 10 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 11 | Interface engineering of plasmonic induced Fe/N/C-F catalyst with enhanced oxygen catalysis performance for fuel cells application显示文摘The low intrinsic activity of Fe/N/C oxygen catalysts restricts their commercial application in the fuel cells technique;herein,we demonstrated the interface engineering of plasmonic induced Fe/N/C-F catalyst with primarily enhanced oxygen reduction performance for fuel cells applications.The strong interaction between F and Fe-N4 active sites modifies the catalyst interfacial properties as revealed by X-ray absorption structure spectrum and density functional theory calculations,which changes the electronic structure of Fe-N active site resulting from more atoms around the active site participating in the reaction as well as super-hydrophobicity from C–F covalent bond.The hybrid contribution from active sites and carbon support is proposed to optimize the three-phase microenvironment efficiently in the catalysis electrode,thereby facilitating efficient oxygen reduction performance.High catalytic performance for oxygen reduction and fuel cells practical application catalyzed by Fe/N/C-F catalyst is thus verified,which offers a novel catalyst system for fuel cells technique. | Xue Yin Ligang Feng Wen Yang Yuanxi Zhang Haiyan Wu Le Yang Lei Zhou Lin Gan Shaorui Sun | 2022 | Nano Research2022，15，3： | 1 |
| 12 | Experimental study on effects of moisture content on combustion characteristics of simulated municipal solid wastes in a fixed bed 显示文摘 | Liang Ligang Sun Rui Fei Jun | 2008 | Bioresource Technology2008，99，15： | 1 |
| 13 | Fault detection of switched linear systems with its application to turntable systems显示文摘This paper is concerned with the H∞ fault detection for continuous-time linear switched systems with its application to turntable systems.The solvability condition for a desired filter is established based on the proposed sufficient condition.Based on the double channel scheme of the turntable control system,the turntable system can be modeled as a switched system.Finally,by taking the turntable system as a numerical example,the effectiveness of the proposed theory is well validated. | Guanghui Sun Mao Wang Xiuming Yao Ligang Wu | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 1 |
| 14 | Analysis of sulfonamides in environmental water samples based magnetic mixed hemimicelles solid-phase extraction coupled with HPLC-UV deteetion显示文摘 | SUN Lei CHEN Ligang SUN Xin | 2009 | Chemosphere2009，77，10： | 1 |
| 15 | Brain‐targeted distribution and high retention of silver by chronic intranasal instillation of silver nanoparticles and ions in Sprague–Dawley rats显示文摘 | Ruoxi Wen Xiaoxi Yang Ligang Hu Cheng Sun Qunfang Zhou Guibin Jiang | 2016 | J. Appl. Toxicol2016，，： | 1 |
| 16 | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats显示文摘Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)rats.The postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals.The HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio meals.The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG groups.The postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups.The 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups.The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats. | Ligang Yang Chao Yang Zhixiu Song Min Wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 17 | Experimental study on effects of moisture content on combustion characteristics of simulated municipal solid wastes in a fixed bed显示文摘 | Ligang Liang Rui Sun Jun Fei Shaohua Wu Xiang Liu Kui Dai Na Yao | 2007 | Bioresource Technology2007，，15： | 1 |
| 18 | Production and Application of Common Type C-Mn Hot Rolled Dual-Phase Steel in CSP Line 显示文摘 | Dong Ruifeng Li Degang Sun Ligang | 2009 | J of Iron and Steel Research International2009，16，： | 1 |
| 19 | Analysis of sulfonamides in environmental water samples based on magnetic mixed hemimicelles solid-phase extraction coupled with HPLC-UV detection显示文摘 | SUN Lei CHEN Ligang SUN Xin | 2009 | Chemosphere2009，77，10： | 1 |
| 20 | Preparation of alumina-coated magnetite nanoparticle for extraction of trimethoprim from environmental water samples based on mixed hemimiceUes solid- phase extraction显示文摘 | SUN Lei ZHANG Chuanzhou CHEN Ligang | 2009 | Analytiea Chimica Acta2009，638，2： | 1 |
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