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| 1 | Human papillomavirus DNA and P16~(INK4A) expression in concurrent esophageal and gastric cardia cancers显示文摘AIM:To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16 INK4A protein expression.METHODS:Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16).The expression of P16 INK4A protein was detected using immunohistochemistry.RESULTS:Among the CC specimens,HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA),respectively (47% vs 29%),and two of both ESCC and GCA.P16 INK4A was highly expressed in both ESCC and GCA.In the HPV-associated positive CC,higher P16 INK4A expression was observed in the GCA than in the ESCC (75% vs 25%,P < 0.05).CONCLUSION:HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA.P16 INK4A may be a screening index in the HPVassociated carcinoma of gastric cardia. | Guang-Cheng Ding,Tao Guo,Department of Gastroenterology,The First Affiliated Hospital and The Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan Province,China Jing-Li Ren,Xin Song,Sheng-Li Zhou,Zong-Min Fan,LiDong Wang,Henan Key Laboratory for Esophageal Cancer Research,Department of Gastroenterology,The First Affiliated Hospital,College of Basic Medicine,Zhengzhou University,Zhengzhou 450052,Henan Province,China Fu-Bao Chang,Department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456500,Henan Province,China Ji-Lin Li,Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456500,Henan Province,China Ling Yuan,Department of Oncoradiotherapy,Henan Province Tumor Hospital,Zhengzhou 450003,Henan Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | A class of primitive substitutions and scrambled sets显示文摘Consider the subshifts induced by constant-length primitive substitutions on two symbols. By investigating the equivalent version for the existence of Li-Yorke scrambled sets and by proving the non-existence of Schweizer-Smítal scrambled sets, we completely reveal for this class of subshifts the chaotic behaviors possibly occurring in the sense of Li-Yorke and Schweizer-Smítal. | LIAO GongFu FAN QinJie WANG LiDong | 2008 | Science China Mathematics2008，51，3： | 7 |
| 3 | Loss of gonadal soma derived factor damaging the pituitary-gonadal axis in medaka显示文摘Medaka sex is determined by dmy/dmrt1b Y,the doublesex and mab-3 domain gene on the Y chromosome[1,2].Most recent studies have revealed a germ cell-intrinsic cue for the sperm-egg fate decision present in medaka,leading to spermatogenesis occurrence in a female gonadal environment without the presence of dmy[3].Targeted disruption of dmy,or sex related genes,such | Kaiqing Sun Lidong Fan Chuanyun Wang Xiaoyu Yang Shuangguang Zhu Xi Zhang Xiaowu Chen Yunhan Hong Guijun Guan | 2017 | Science Bulletin2017，62，3： | 4 |
| 4 | Development of a Soil Stabilizer for Road Subgrade Based on Original Phosphogypsum显示文摘The research used industrial by-products original phosphogypsum(PG)as the main raw material,slag(SG)and Portland cement(PC)as auxiliary materials,and the optimal additive amount was determined according to the compressive strength value of the sample.Comprehensively evaluate the water resistance and volume stability of the samples,and determine the best formula for new roadbed stabilized materials.The results showed that when the weight ratio of PG,slag and cement was OPG:SG:PC=6:3:1,and mixed with 5%micro silica fume(MSF)and 3‰hydroxypropyl methyl cellulose(HPMC),the sample’s comprehensive performance was the best,specifically,the sample’s compressive strength in 60 days reached 28.8 MPa,the softening coefficient reached 0.9,and the expansion rate was stable at about−0.2%.In addition,the mechanism of action of enhancers MSF and HPMC was analyzed according to use Vicat device,X-ray diffractometer and scanning electron microscope.The best formula SP3GH3 has the best curing effect on soil.The 28-day unconfined compressive strength(UCS)of the sample reached 2.4 MPa,the expansion rate was less than 0.09%,and the water stability coefficient was above 0.79,which was higher than that of the samples cured by traditional cement and lime during the same period. | Zenghuan Gu Aiguo Fang Sudong Hua Qingzhou Zhao Lidong Sun Fan Xia Liying Qian Xiaojian Ren | 2021 | Journal of Renewable Materials2021，9，2： | 2 |
| 5 | Cytological screen- ing and 15 years' follow - up ( 1986 - 2001 ) for early esophageal squamous cell carcinoma and precancerous lesions in a high - risk population in anyang county, henan province, Northern China 显示文摘 | Lidong Wang Huaihua Yang ZongMin Fan | 2005 | Cancer Detection and Prevention2005，29，： | 1 |
| 6 | Application of grey system theory to study the bond strength between corroded rebar and concrete显示文摘 | Zhang Yingzi Fan yingfang hu yudong lidong | 2007 | in GSIS2007，，： | 1 |
| 7 | Simultaneous Determination of Benzene and Toluene in Pesticide Emulsifiable Concentrate by Headspace GC-MS显示文摘 | Lidong Cao Hua Jiang Jing Yang Li Fan Fengmin Li Qiliang Huang Miguel de la Guardia | 2013 | Journal of Analytical Methods in Chemistry2013，，： | 1 |
| 8 | Polyethylene with bimodal molecular weight distribution synthesized by 2,6-bis(imino) pyridyl complexes of Fe(Ⅱ) activated with various activators 显示文摘 | Wang Qi Li lidong Fan Zhiqiang | 2004 | Eur Polym J2004，40，： | 1 |
| 9 | Polyethylene with bi- modal molecular weight distribution synthesized by 2,6-bis (imino) pyridyl complexes of Fe ( U ) activated with various activators显示文摘 | Wang Qi Li Lidong Fan Zhiqiang | 2004 | Eur Polym2004，40，8： | 1 |
| 10 | Geochronological Framework of Paleoproterozoic Intrusive Rocks and Its Constraints on Tectonic Evolution of the Liao-Ji Belt,Sino-Korean Craton显示文摘The Liao-Ji belt(LJB)is one of the Paleoproterozoic tectonic belts located in the North China Craton.A large number of Paleoproterozoic meta-volcanic-sedimentary rock and intrusive rocks are preserved in the LJB,which provide reliable carriers for the study of the Paleoproterozoic tectonic evolution of the North China Craton.The Paleoproterozoic intrusive rock in the LJB can be divided into the following seven types:syenogranite,quartz diorite,porphyry granite,migmatitic granite,sye-nite,metamorphic plutonic rock,and granitic pegmatite and metagabbro(metamorphic diabase).Zir-con U-Pb dating of 15 samples from intrusive rocks was carried out in this study.The chronology framework of the Paleoproterozoic intrusive rock in the LJB was established,and the magmatism of intrusive rocks can be divided into three stages:2200 to 2110,2010 to 1937,1900 to 1820 Ma.The chronological framework supported the evolution model of subduction accretionary arc-continent colli-sion in the LJB effectively.Combined with previous geochemical work,it was a passive continental margin environment at approximately 2200 Ma,and then transformed into and active continental margin.The bimodal intrusive rocks between 2180 and 2150 Ma indicated a back-arc tension envi-ronment which lasted until approximately 2110 Ma with a large number of basic intrusive rocks.And then the back-arc basin began to contract and the magmatic activities were reduced,with only a small number of intrusive rock activities occurring at approximately 2040,2010 and 1937 Ma.After the orogenic activities,there was a post-orogenic extension stage from 1900 to 1820 Ma.Magmatic activi-ties caused by the environmental extension started to occur more frequently and subsequently resulted in the large-scale intrusive rocks in eastern Liaoning. | Jingsheng Chen Zhongzhu Yang Dexin Tian Dehe Xing Lidong Zhang Fan Yang Bin Li Miao Liu Yi Shi Chao Zhang | 2021 | Journal of Earth Science2021，32，1： | 1 |
| 11 | Biodiversity and phylogenetic analysis of the gut microbiome of Euphausia superba Dana from the Rose Sea of the Antarctic Ocean显示文摘Metabolites derived from marine symbiotic microorganisms have great potential as lead compounds for the discovery of novel marine drugs. Euphausia superba Dana, which lives in the Antarctic Ocean, is regarded as a new source of marine microbial natural products. However, no studies have examined the biodiversity of the symbiotic intestinal microbiome of E. superba. To address this issue, the species diversity and abundance of the gut microbiome of E. superba Dana from the Rose Sea of the Antarctic Ocean were analyzed by culture-independent high-throughput sequencing and pure culture methods. A comparison with gene databases revealed that the microbiome contained 61 known microbial species and a plethora of uncultivable microorganisms. Additionally, 7% of the species in the microbiome were currently unknown. The microbes belonged to 56 genera, eight of which, including Arthrobacter, Bacillus, Candidatus, Lactococcus, Lysinibacillus, Leuconostoc, Solibacillus, and Vibrio, were dominant, as were Vibrionaceae spp. Moreover, 81 microbial strains were isolated by the pure culture method, and they belonged to 36 genera, including Mobilicoccus, Rhodococcus, Arthrobacter, and Microbacterium. The results obtained by two different methods demonstrate the richness of the microbial biodiversity of the gut microbiome of E. superba, and it also suggests that they have good potential for the discovery of novel marine microbial species. | YUAN Lidong LI Lingzhi TIAN Xiaoqing TANG Yingying FAN Chengqi HUANG Hongliang YANG Qiao | 2016 | Advances in Polar Science2016，27，1： | 1 |
| 12 | Microbial activity facilitates phosphorus adsorption to shallow lake sediment显示文摘 | Huang Lidong Du Shaoting Fan Lin | 2011 | Journal of Soils and Sediments2011，11，1： | 1 |
| 13 | The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. | Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 14 | VT3D:a visualization toolbox for 3D transcriptomic data显示文摘Data visualization empowers researchers to communicate their results that support scientific reasoning in an intuitive way.Three-dimension(3D)spatially resolved transcriptomic atlases constructed from multi-view and high-dimensional data have rapidly emerged as a powerful tool to unravel spatial gene expression patterns and cell type distribution in biological samples,revolutionizing the understanding of gene regulatory interactions and cell niches.However,limited accessible tools for data visualization impede the potential impact and application of this technology.Here we introduce VT3D,a visualization toolbox that allows users to explore 3D transcriptomic data,enabling gene expression projection to any 2D plane of interest,2D virtual slice creation and visualization,and interactive 3D data browsing with surface model plots.In addition,it can either work on personal devices in standalone mode or be hosted as a web-based server.We apply VT3D to multiple datasets produced by the most popular techniques,including both sequencing-based approaches(Stereo-seq,spatial transcriptomics,and Slide-seq)and imaging-based approaches(MERFISH and STARMap),and successfully build a 3D atlas database that allows interactive data browsing.We demonstrate that VT3D bridges the gap between researchers and spatially resolved transcriptomics,thus accelerating related studies such as embryogenesis and organogenesis processes.The source code of VT3D is available at http://gffzz188fe103f8f1460aso6wk5wvqqv6566xu.ffgz.tsg.suse.edu.cn/BGI-Qingdao/VT3D,and the modeled atlas database is available at http://gffzz975da403144c4764ho6wk5wvqqv6566xu.ffgz.tsg.suse.edu.cn/vt3d_example. | Lidong Guo Yao Li Yanwei Qi Zhi Huang Kai Han Xiaobin Liu Xin Liu Mengyang Xu Guangyi Fan | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
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