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| 1 | Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability显示文摘Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. | Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang | 2018 | Science China Chemistry2018，61，1： | 1 |
| 2 | A carbon nanotubes based ATP apta-sensing platform and its application in cellular assay显示文摘 | Libing Zhang Hui Wei Jing Li Tao Li Dan Li Yunhui Li Erkang Wang | 2010 | Biosensors and Bioelectronics2010，，8： | 1 |
| 3 | An electrochemical machining method for aeroengine blades based on four-directional synchronous feeding of cathode tools显示文摘Blades are critical components of modern aero-engine.Among the many characteristic structures of the blade,the leading/trailing edges are key structures that have the greatest influence on the aerodynamic effect and power conversion of the blade.Electrochemical machining(ECM)is regarded as one of the most important techniques in blade manufacturing due to its process characteristics of high material removal rates,virtually no tool wear,and no areas of thermal or mechanical damage to the workpiece rim zones.Herein,an ECM method based on the fourdirectional synchronous feeding of four cathode tools is proposed to improve the machining accuracy of the leading and trailing edges of the blade.During blade ECM using this method,four cathode tools feed toward the basin/back surfaces and leading/trailing edges respectively.The dynamic processing simulation and flow field simulation results of the ECM process show that the proposed method eliminates the sharp changes in the electric field and electrolyte flow field at the leading and trailing edges seen in traditional machining methods.Thus,the electric field and flow field stability of the leading and trailing edges at the final stage of machining is greatly improved.Experimental comparison of the conventional and proposed ECM methods showed that four-directional synchronous feeding results in improved profile accuracy over repeated machining processes and good surface quality. | Jia LIU Libing HUI Dongqian JIA Yan LIU Di ZHU | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 4 | Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfskpo5ucxbpop56fuk.ffgz.tsg.suse.edu.cn/10.1038/cr.2012.174,published online 18 December 2012 With this letter we the authors of article1 published in Cell Research request for correction to the paper.In the article above referred,it has come to our attention that the representative tube formation images of negative control(NC)was mistakenly used in the Fig.7G during figure assembly. | Libing Song Chuyong Lin Hui Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2021 | Cell Research2021，31，10： | 0 |
| 5 | Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study显示文摘For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein thrombosis.Surgery is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury patients.Development of effective therapies fo r chronic spinal co rd injury patients is needed.We conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive rehabilitation.This clinical trial was registered at ClinicalTrials.gov(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord compression.We found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training alone.Overall,the surgical procedures and intensive rehabilitation were safe.American Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 injuries.Surgery combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients. | Hui Zhu James D.Guest Sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo Joe E.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-Ming Xu | 2024 | Neural Regeneration Research2024，19，12： | 0 |
| 6 | High-performance fiber strain sensor of carbon nanotube/thermoplastic polyurethane@styrene butadiene styrene with a double percolated structure显示文摘In this work,a high-performance fiber strain sensor is fabricated by constructing a double percolated structure,consisting of carbon nanotube(CNT)/thermoplastic polyurethane(TPU)continuous phase and styrene butadiene styrene(SBS)phase,incompatible with TPU(CNT/TPU@SBS).Compared with other similar fiber strain sensor systems without double percolated structure,the CNT/TPU@SBS sensor achieves a lower percolation threshold(0.38 wt.%)and higher electrical conductivity.The conductivity of 1%-CNT/TPU@SBS(4.12×10^(-3) S·m^(-1))is two orders of magnitude higher than that of 1%-CNT/TPU(3.17×10^(-5) S·m^(-1))at the same CNT loading of 1 wt.%.Due to double percolated structure,the 1%-CNT/TPU@SBS sensor exhibits a wide strain detection range(0.2%-100%)and an ultra-high sensitivity(maximum gauge factor(GF)is 32411 at 100%strain).Besides,the 1%-CNT/TPU@SBS sensor shows a high linearity(R^(2)=0.97)at 0%-20%strain,relatively fast response time(214 ms),and stability(500 loading/unloading cycles).The designed sensor can efficiently monitor physiological signals and movements and identify load distribution after being woven into a sensor array,showing broad application prospects in wearable electronics. | Dong XIANG Libing LIU Xiaoyu CHEN Yuanpeng WU Menghan WANG Jie ZHANG Chunxia ZHAO Hui LI Zhenyu LI Ping WANG Yuntao LI | 2022 | Frontiers of Materials Science2022，16，1： | 0 |
| 7 | A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy显示文摘It is of great significance to develop effective antibacterial agents and methods to combat drug resistant bacterial infections due to its increasing threaten to human health and the ineffectiveness of antibiotics.Herein,a multifunctional hybrid nano-assembly(M1-Fe NPs)based on conjugated oligomer and ferrous ion was engineered with favorable bactericidal activity for synergetic antibacterial therapy.The chelation of ferrous ion not only enhances the photothermal conversion efficiency of M1 but also endows the nano-assembly with catalytic capability of transferring H_(2)O_(2) into stronger oxidant hydroxyl radicals(·OH).Meanwhile,the generated heat can further promote the Fenton reaction activity.By generating cytotoxic heat and oxidative·OH,M1-Fe NPs can effectively kill Staphylococcus aureus in vitro and in vivo with the aid of low dosage of H_(2)O_(2).The work provides a new multifunctional platform for combinational drug resistant antibacterial therapy and even antitumor therapy. | Yunxia Wang Chuangxin Zhang Hui Zhang Liheng Feng Libing Liu | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
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