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| 1 | The acidic tumor microenvironment: a target for smart cancer nano-theranostics显示文摘The acidic tumor microenvironment(TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article,we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards. | Liangzhu Feng Ziliang Dong Danlei Tao Yicheng Zhang Zhuang Liu | 2018 | National Science Review2018，5，2： | 14 |
| 2 | Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy显示文摘Though photodynamic therapy (PDT) has been widely used in the non-invasive destruction of solid tumors, the therapeutic efficacy of PDT is often limited by the hypoxic tumor environment. Herein, we report the innovative use of metformin, an oral hypoglycemic agent commonly used in the treatment of type II diabetes, to improve tumor oxygenation, and overcome tumor hypoxia-associated resistance to PDT. In our design, hydrophilic metformin and modified hydrophobic chlorin e6 (HCe6) are co-encapsulated within the inner cavity and outer membrane of liposomes, respectively. Due to the high uptake of liposome nanoparticles by tumors, and the sustained release of metformin, the intravenous administration of metformin (Met)-HCe6-Liposome nanoparticles greatly improves tumor oxygenation in several different tumor models, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining. Systemic administration of Met-HCe6-Liposomes followed by in vivo PDT achieved significantly improved therapeutic effects compared to that of PDT without metformin. Hence, our study represents a new strategy for the improvement of PDT efficacy through the modulation of tumor oxygenation by clinically approved agents. | Xuejiao Song Liangzhu Feng Chao Liang Min Gao Guosheng Song Zhuang Liu | 2017 | Nano Research2017，10，4： | 12 |
| 3 | Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats显示文摘Aim: To examine the tolerance of type 1 diabetic hearts to ischemia and reperfusion injury. Myocardial contents of 27-kDa and 70-kDa heat shock proteins (hsp) as well as phosphorylated hsp27 were also determined. Methods: Hearts from hyperglycemic rats 3 weeks after streptozocin injection and age-matched normal rats were subjected to ischemia and reperfusion in vitro. Cardiac function and electrocardiogram were recorded throughout experiments. Myocardial heat shock proteins were detected with Western blot. Results: Despite depressed systolic function at the baseline, diabetic hearts exhibited considerable enhancement in postischemic heart function, manifested by an increase in the maximal rate of left ventricular pressure rise and fall (post-ischemic dp/dtmax and dp/dtmin were 560±117 and -313±68 mmHg/s in control, n=7, 1249±57 and -1204±36 mmHg/s in diabetes, n= 10, P<0.01). Reperfusion ventricular fibrillation in the diabetic group were attenuated compared with controls (1.5±0.3 vs 7.2±2.1 min in control, P<0.01). The increased heart resistance to ischemia in diabetes was associated with hyperglycemia and accompanied by enhanced expression of myocardial phosphorylated hsp27 with normal aortic vessel relaxation. Cardioprotection was abrogated by metabolic correction with insulin and accompanied by phospho-hsp27 reduction. Conclusion: Heart resistance to ischemia is increased in type 1 diabetes, and hyperglycemia may present a mild yet stressful stimulus leading to upregulation of endogenous stress protein, which may play a potential role in cardioprotection and compensate for detrimental effects of hyperglycemia in diabetes. | HongCHEN Xing-junWU Xi-yuanLU LiangZHU Li-pingWANG Huang-tianYANG Hong-zhuanCHEN Wen-junYUAN | 2005 | Acta Pharmacologica Sinica2005，26，7： | 11 |
| 4 | Meta analysis of propranolol effects on gastrointestinal hemorrhage in cirrhotic patients显示文摘AIM: To assess the effects of propranolol as compared with placebo on gastrointestinal hemorrhage and total mortality in cirrhotic patients by using meta analysis of 20 published randomized clinical trials.METHODS: A meta analysis of published randomized clinical trials was designed. Published articles were selected for study based on a computerized MEDLINE and a manual search of the bibliographies of relevant articles. Data from 20 relevant studies fulfilling the inclusion criteria were retrieved by means of computerized and manual search.The reported data were extracted on the basis of the intention-to-treat principle, and treatment effects were measured as risk differences between propranolol and placebo. Pooled estimates were computed according to a random-effects model. We evaluated the pooled efficacy of propranolol on the risk of gastrointestinal hemorrhage and the total mortality.RESULTS: A total of 1 859 patients were included in 20trials, 931 in the propranolol groups and 928 as controls.Among the 652 patients with upper gastrointestinal tract hemorrhage, 261 patients were treated with propranolol,and 396 patients were treated with placebo or non-treated.Pooled risk differences of gastrointestinal hemorrhage were -18 % [95 % CI, -25 %, -10 %] in all trials, -11% [95 % CI,-21%, -1%] in primary prevention trials, and -25 %[95 %CI, -39 %, -10 %] in secondary prevention trials. A total of 440 patients died, 188 in propranolol groups and 252 in control groups. Pooled risk differences of total death were -7 %[95% CI, -12 %, -3 %] in all trials, -9 %[95 % CI, -18 %, -1%]in primary prevention trials, and -5 %[95 %CI, -9 %, -1%]in secondary prevention trials.CONCLUSION: Propranolol can markedly reduce the risks of both primary and recurrent gastrointestinal hemorrhage,and also the total mortality. | Jin-WeiCheng LiangZhu Ming-JunGu Zhe-MingSong | 2003 | World Journal of Gastroenterology2003，9，8： | 8 |
| 5 | Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures显示文摘为肿瘤的高度精确的治疗的激活刺激的指向的交货系统在最近的年里收到了可观的注意。此处,我们揭示使用一个互补 DNA 序列到 hybridize 和结合到象金 nanorods 或围单人赛的碳 nanotubes (SWNT ) 那样的 photothermal 代理人上的面具 sgc8 aptamers 的光能被活化的指向癌症的策略。在暴露到之上在红外线附近(NIR ) 激光,局部性的 photothermal 在双 stranded DNA 的 dehybridization 加热那些 nano 代理人结果的表面并且 aptamer 顺序放允许指向的特定的癌症房间。作为一个模型系统利用装载 doxorubicin 的 SWNT,到 NIR 光激活的癌症房间的指向的药交货被完成。这个工作与有约束力的可控制的癌症房间表明 NIR 能被活化的指向肿瘤的交货系统的概念潜在地启用高度特定、有效的癌症治疗。 | Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen | 2016 | Nano Research2016，0，1： | 4 |
| 6 | Ink formulation, scalable applications and challenging perspectives of screen printing for emerging printed microelectronics显示文摘Screen printing is regarded as a highly competitive manufacture technology for scalable and fast fabrication of printed microelectronics, owing to its advanced merits of low-cost, facile operability and scalability.However, its large-scale application in printed microelectronics is still limited by screen printing functional ink. In this review, we summarize the recent advances of ink formation, typical scalable applications, and challenging perspectives of screen printing for emerging printed microelectronics. Firstly, we introduce the major mechanism of screen printing and the formation of different organic-and aqueous-based inks by various solvents and binders. Next, we review the most widely used applications of screen printing technique in micro-batteries, micro-supercapacitors and micro-sensors, demonstrative of wide applicability.Finally, the perspectives and future challenges in the sight of screen printing are briefly discussed. | Ying Zhang Yuanyuan Zhu Shuanghao Zheng Liangzhu Zhang Xiaoyu Shi Jian He Xiujian Chou Zhong-Shuai Wu | 2021 | Journal of Energy Chemistry2021，30，12： | 3 |
| 7 | Optimization of passive solar design and integration of building integrated photovoltaic/thermal(BIPV/T)system in northern housing显示文摘In the Canadian north,the cost of space heating is very high due to the harsh weather,its remoteness,lack of transportation,and dependency on the high cost of fossil fuel imported from the South.Since the North has an abundance of solar energy,significant energy savings with some added construction cost in houses could be achieved by applying high-performance building envelopes and solar design strategies.The objective of this paper is to investigate the potential of both passive and active solar design strategies in improving the energy efficiency of northern housing.Firstly,a reference house representing a typical single-family home in the North is modeled using EnergyPlus,and the key passive design parameters are optimized to minimize life-cycle cost.Then,the air-based building integrated photovoltaic/thermal(BIPV/T)system is applied to the optimized house and integrated with HVAC systems.It is found that optimal passive solar design can reduce the heating energy demand by 42%with an incremental cost of 8%for Yellowknife and by 27%without incurring an incremental cost for Kuujjuaq.Integrating BIPV/T with HVAC systems can reduce the defrost time of heat recovery ventilator(HRV),extend the working hours and improve the COP of air source heat pump(ASHP).The reduction in the total energy consumption is in the range of 1,4%-3.0%by integrating HRV and 0.3%-0.6%by integrating ASHP due to the mis-match of solar availability and heating energy demand.To maximize the utilization of solar energy available,the optimal use of thermal energy recovered from BIPV/T system in northern housing requires further investigation. | Li Ma Hua Ge Lin Wang Liangzhu Wang | 2021 | Building Simulation2021，14，5： | 3 |
| 8 | Nanoscale covalent organic polymers as a biodegradable nanomedicine for chemotherapy-enhanced photodynamic therapy of cancer显示文摘 | Hairong wang Wenwen Zhu Liangzhu Feng Qian Chen Yu Chao Ziliang Dong Zhuang Liu | 2018 | Nano Research2018，11，6： | 3 |
| 9 | CaCO3-Assisted Preparation of pH-Responsive Immune-Modulating Nanoparticles for Augmented Chemo-Immunotherapy显示文摘Due to the negative roles of tumor microenvironment(TME)in compromising therapeutic responses of various cancer therapies,it is expected that modulation of TME may be able to enhance the therapeutic responses during cancer treatment.Herein,we develop a concise strategy to prepare pH-responsive nanoparticles via the CaCO3-assisted double emulsion method,thereby enabling effective co-encapsulation of both doxorubicin(DOX),an immunogenic cell death(ICD)inducer,and alkylated NLG919(aNLG919),an inhibitor of indoleamine 2,3-dioxygenase 1(IDO1).The obtained DOX/aNLG919-loaded CaCO3 nanoparticles(DNCaNPs)are able to cause effective ICD of cancer cells and at the same time restrict the production of immunosuppressive kynurenine by inhibiting IDO1.Upon intravenous injection,such DNCaNPs show efficient tumor accumulation,improved tumor penetration of therapeutics and neutralization of acidic TME.As a result,those DNCaNPs can elicit effective anti-tumor immune responses featured in increased density of tumor-infiltrating CD8+cytotoxic T cells as well as depletion of immunosuppressive regulatory T cells(Tregs),thus effectively suppressing the growth of subcutaneous CT26 and orthotopic 4T1 tumors on the Balb/c mice through combined chemotherapy&immunotherapy.This study presents a compendious strategy for construction of pH-responsive nanoparticles,endowing significantly enhanced chemo-immunotherapy of cancer by overcoming the immunosuppressive TME. | Yujie Zhu Zhijuan Yang Ziliang Dong Yimou Gong Yu Hao Longlong Tian Xianzhu Yang Zhuang Liu Liangzhu Feng | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 10 | Mechanism of calcium lignosulfonate in apatite and dolomite flotation system显示文摘Since the physical and chemical properties of apatite and dolomite can be similar,the separation of these two minerals is difficult.Therefore,when performing this separation using the flotation method,it is necessary to search for selective depressants.An experimental research was performed on the separation behavior of apatite and dolomite using calcium lignosulfonate as a depressant,and the mechanism by which this occurs was analyzed.The results show that calcium lignosulfonate has a depressant effect on both apatite and dolomite,but the depressant effect on dolomite is stronger at the same dosage.Mechanism analysis shows that the adsorptive capacity of calcium lignosulfonate on dolomite is higher than that of apatite,which is due to the strong reaction between calcium lignosulfonate and the Ca sites on dolomite.In addition,there is a hydrogen bond between calcium lignosulfonate and dolomite,which further prevents the adsorption of sodium oleate to dolomite,thus greatly inhibiting the flotation of dolomite. | Bo Feng Liangzhu Zhang Wenpu Zhang Huihui Wang Zhiyong Gao | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 2 |
| 11 | High Rate and Long Lifespan Sodium‑Organic Batteries Using Pseudocapacitive Porphyrin Complexes‑Based Cathode显示文摘Sodium-organic batteries utilizing natural abundance of sodium element and renewable active materials gain great attentions for grid-scale applications.However,the development is still limited by lack of suitable organic cathode materials with high electronic conductivity that can be operated stably in liquid electrolyte.Herein,we present 5,15-bis(ethynyl)-10,20-diphenylporphyrin(DEPP)and[5,15-bis(ethynyl)-10,20-diphenylporphinato]copper(II)(CuDEPP)as new cathodes for extremely stable sodium-organic batteries.The copper(II)ion partially contributes the charge storage and significantly stabilizes the structure of porphyrin complex for electrochemical energy storage.In situ electrochemical stabilization of organic cathode with a lower charging current density was identified which enables both improved high energy density and power density.An excellent longterm cycling stability up to 600 cycles and an extremely high power density of 28 kW kg−1 were achieved for porphyrin-based cathode.This observation would open new pathway for developing highly stable sodium-organic cathode for electrochemical energy storage. | Xi Chen Xin Feng Bo Ren Liangzhu Jiang Hongbo Shu Xiukang Yang Zhi Chen Xiujuan Sun Enhui Liu Ping Gao | 2021 | Nano-Micro Letters2021，13，5： | 1 |
| 12 | Virus‐induced gene silencing in tomato fruit显示文摘 | Da‐QiFu Ben‐ZhongZhu Hong‐LiangZhu Wei‐BoJiang | 2005 | The Plant Journal2005，，2： | 1 |
| 13 | A novel Web page filtering system by combining texts and images显示文摘 | Zhou yaochen Wu Ming liangzhu | 2006 | IEEE Computer Society2006，，： | 1 |
| 14 | The theory of compression–shear coupled composite wave propagation in rock显示文摘The wave velocity analysis of rock medium is the main method used to explore the internal compositions in the crust and research seismic.In this paper,a compression–shear coupled nonlinear elastic constitutive relation is established,which is consistent with the mechanical properties of rock and mineral medium under high pressure.On this basis,numerical solutions of the wave equation and plane wave analytical solutions for the primary and secondary wave velocities are obtained.As is indicated by the comparison with the linear elastic constitutive theory,the results reflect the compression–shear coupling characteristics of the rock,including the stress path effect and the compression–shear coupling wave effect.With different parameter values,the velocity of the secondary wave changes from lower than that of the elastic shear wave,to higher than that of the elastic shear wave.The research results are expected to provide meaningful explanations for the physical mechanisms of the supershear wave and sub-Rayleigh wave,and guidance for the detection of rock and soil composition and the observation of seismic waves. | Jianhua Lu Songlin Xu Chunhe Miao Yushan Xie Liangzhu Yuan Hao Ma Meiduo Chen Pengfei Wang | 2022 | Deep Underground Science and Engineering2022，1，1： | 1 |
| 15 | Computer modeling of muhiscale fluid flowand heat and mass transfer in engineered spaces显示文摘 | Chen Qingyan Zhai Zhiqiang Wang Liangzhu | 2007 | Chemical Engineering Science2007，62，13： | 1 |
| 16 | Investigation of UDP‐glucuronosyltransferases (UGTs) Inhibitory Properties of Carvacrol显示文摘 | Rui‐HuaDong Zhong‐ZeFang Liang‐LiangZhu Si‐ChengLiang Guang‐BoGe LingYang Ze‐YuanLiu | 2012 | Phytother Res2012，，1： | 1 |
| 17 | Low-temperature and high-voltage planar micro-supercapacitors based on anti-freezing hybrid gel electrolyte显示文摘Micro-supercapacitors(MSCs)are considered as highly competitive power sources for miniaturized electronics.However,narrow voltage window and poor anti-freezing properties of MSCs in conventional aqueous electrolytes lead to low energy density and limited environmental adaption.Herein,we report the construction of low-temperature and high-energy-density MSCs based on anti-freezing hybrid gel electrolytes(HGE)through introducing ethylene glycol(EG)additives into aqueous LiCl electrolyte.Since EG partially destroys hydrogen bond network among water molecules,the HGE exhibits maximum electrochemical stability window of 2.7 V and superior anti-freezing features with a glass transition temperature of-62.8℃.Further,the optimized MSCs using activated carbon microelectrodes possess impressive volumetric capacitance of 28.9 F cm^(-3)and energy density of 10.3 mWh cm^(-3)in the voltage of 1.6 V,2.6 times higher than MSCs tested in 1.2 V.Importantly,the MSCs display 68.3%capacitance retention even at-30℃ compared to the value at 25℃,and ultra-long cyclability with 85.7%of initial capacitance after 15,000 times,indicating extraordinary low-temperature performance.Besides,our devices offer favorable flexibility and modular integration.Therefore,this work provides a general strategy of realizing flexible,safe and anti-freezing microscale power sources,holding great potential towards subzero-temperature microelectronic applications. | Manning Chen Xiaoyu Shi Xiaolei Wang Hanqing Liu Sen Wang Caixia Meng Yu Liu Liangzhu Zhang Yuanyuan Zhu Zhong-Shuai Wu | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
| 18 | Evaluation of some assumptions used in multizone airflow network models 显示文摘 | Wang Liangzhu Chen Qingyan | 2008 | Building and Enviroment2008，43，10： | 1 |
| 19 | A novel Web page filtering system by combining texts and images显示文摘 | Zhou yaochen Ou Wu Ming liangzhu | 2006 | IEEE Computer Society2006，，： | 1 |
| 20 | Evaluation of some assumptions used in multizone airflow network models显示文摘 | Liangzhu (Leon) Wang Qingyan Chen | 2007 | Building and Environment2007，，10： | 1 |
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