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| 1 | Combined human growth hormone and lactulose for prevention and treatment of multiple organ dysfunction in patients with severe chronic hepatitis B显示文摘AIM: To evaluate the efficiency and safety of combined recombinant human growth hormone (rhGH) and lactulose for treatment and/or prevention of multiple organ dysfunction in patients with chronic severe hepatitis B. METHODS: Forty-eight inpatients with chronic severe hepatitis B were randomly divided into rhGH group (n = 28)and control group (n = 20). In rhGH group, 4-4.5 IU of rhGH was injected intramuscularly once daily for 2-4 wk,and 100 mL of enema containing 30 mL of lactulose, 2 g of metronidazole and 0.9% saline was administered every 2 d for 2-4 wk. Their symptoms and complications were noted. Liver and kidney functions were analyzed by an Olympus analyzer. Serum GH, IGF-1, IGFBP1 and IGFBP3 were measured by ELISA.RESULTS: Clinical symptoms of 90% of these patients in rhGH group were obviously improved. The total effectiveness in rhGH group was better than that in control group (75% vs40%, P<0.05). After 2- and 4-wk treatment of rhGH respectively, serum albumin (26.1±4.1 vs 30.2±5.3,31.9±5.1 g/L), prealbumin (79.6±28.0 vs 106.6±54.4,108.4±55.0 g/L), cholesterol (76.3±16.7 vs 85.6±32.3,96.1±38.7 mg/dL), and IGFBP1 (56.8±47.2 vs 89.7±50.3ng/mL after 2 wk) were significantly increased compared to control group (P<0.05). However, serum GH was decreased. The increase of serum IGF1 and IGFBP3 after rhGH treatment was also observed.CONCLUSION: rhGH in combination with lactulose may be beneficial to the prevention and treatment of multiple organ dysfunction in patients with chronic severe hepatitis. | Hui-GuoDing JingShan BinZhang Hong-BoMa LiZhou RuiJin Yu-FenTan Li-XiangHe | 2005 | World Journal of Gastroenterology2005，11，19： | 13 |
| 2 | An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy:study protocol for a randomized controlled feasibility study显示文摘Background:Breast cancer patients experience various side effects during cancer therapy, often resulting in reduced quality of life and poor adherence to treatment. A limited range of proven interventions has been developed to target such side effects. While Tai Chi offers benefits for the health and well-being of breast cancer survivors, the effectiveness of Tai Chi across the treatment continuum has not been evaluated. Improved patient education and support has been suggested as a priority for breast cancer care. This pilot study assesses the feasibility of a randomized controlled trial(RCT) to evaluate the effectiveness of‘‘an integrative Tai Chi'(ANITA) program for breast cancer patients undergoing cancer therapy.Methods/design: This is a single-centre, two-arm feasibility RCT. Twenty-four patients with breast cancer who have undergone surgical treatment will be recruited from the Dunedin Hospital(New Zealand) over a 12-month period(from August 2017 to July 2018). Subject to informed consent, patients will be randomized to receive standard cancer treatment alone or standard cancer treatment plus the ANITA program, consisting of peer support, health education, and Tai Chi Ruler exercise. The program runs alongside the patient's adjuvant cancer therapy, which may include chemotherapy, radiation therapy,antibody treatment, and/or antihormonal therapy. Analysis in this study will focus on process evaluation of participant recruitment, retention, treatment fidelity, acceptability of the program, and occurrence of adverse events. Clinical outcomes(i.e., fatigue, sleep quality, anxiety and depression and quality of life)will be assessed at baseline, and at 12 weeks and 24 weeks post-randomization.Discussion: Outcomes from this study will inform the feasibility and methodology for a future fullypowered RCT. | Lizhou Liu Simone Petrich Blair McLaren Lyndell Kelly G.David Baxter | 2018 | Journal of Integrative Medicine2018，16，2： | 4 |
| 3 | Distributed Energy Management of Integrated Electricity-thermal Systems for High-speed Railway Traction Grids and Stations显示文摘This paper proposes an integrated electricity-ther-mal energy management system(EMS)for high-speed railways.First,an operational model is built for the integrated electricity-thermal system,including a train operation EMS(TO-EMS)model and station operation EMS(SO-EMS)model.In the TO-EMS model,traction grids(TGs)are formulated with a solvable second-order cone programming problem.In the SO-EMS model,station indoor thermal systems are taken into account,and the building heat exchange process and solar radiation influence upon station indoor temperature are also included.Then the TO-EMS and the SO-EMS are coordinated with an alternating direction method of the multipliers-based(ADMM-based)algo-rithm,protecting the privacy and interests both for the train dispatch center and stations.To demonstrate the effectiveness of the proposed railway EMS,a modified realistic high-speed railway segment with six stations in North China with summer and winter scenarios is studied. | Lizhou Jiang Zhaohong Bie Tao Long Haipeng Xie Yao Xiao | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 4 |
| 4 | 当归芍药散治疗阿尔茨海默病的作用机制实验研究进展显示文摘阿尔茨海默病(AD)是一种起病隐匿并呈进行性发展的神经系统退行性疾病,已成为全球重大健康和社会经济问题。AD发病机制十分复杂,存在β淀粉样蛋白过度沉积、Tau蛋白过度磷酸化、氧化应激、炎症等多种假说,因此迫切需要多途径、多环节、多靶点的整体综合调治措施的干预。这正是中医药的特色与优势。开展和加强中医药治疗本病的研究,具有重大意义。当归芍药散出自《金匮要略》,该方肝脾同调、血水并治,原为疗妇人之疾而设,自20世纪80年代末首次被日本学者用于治疗AD获效后,逐渐被广泛用于临床,疗效确切。阐明此方作用机理有助于其治疗优势的发挥。该文综述近年来相关实验研究进展,就其减少β-淀粉样蛋白过度沉积、抑制Tau蛋白异常磷酸化、改善氧化应激损伤、抑制炎症反应、调节乙酰胆碱相关酶类、增加α7烟碱样乙酰胆碱受体、调节脂质代谢、改善肠道菌群、拮抗神经细胞凋亡、降低胞内Ca2+超载并提高雌二醇激素水平等机制进行论述,以期为阐明此方治疗AD的科学内涵提供文献支持,并为进一步研究奠定基础。 | 陈云慧 夏军 刘丹 刘兴隆 张天娥 DAVID BAXTER George LIU Lizhou 游宇 谢永美 龚圆渊 彭伟 | 2022 | 中国实验方剂学杂志2022，28，24： | 3 |
| 5 | Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrugresistant tumors using multifunctional dendrimer/carbon dot nanohybrids显示文摘Development of innovative nanomedicine enabling enhanced theranostics of multidrug-resistant(MDR)tumors remains to be challenging.Herein,we report the development of a newly designed multifunctional yellowfluorescent carbon dot(y-CD)/dendrimer nanohybrids as a platform for ultrasound(US)-enhanced fluorescence imaging and chemotherapy of MDR tumors.Generation 5(G5)poly(amidoamine)dendrimers covalently modified with efflux inhibitor of D-α-tocopheryl polyethylene glycol 1000 succinate(G5-TPGS)were complexed with one-step hydrothermally synthesized y-CDs via electrostatic interaction.The formed G5-TPGS@y-CDs complexes were then physically loaded with anticancer drug doxorubicin(DOX)to generate(G5-TPGS@y-CDs)-DOX complexes.The developed nanohybrids display a high drug loading efficiency(40.7%),strong y-CD-induced fluorescence emission,and tumor microenvironment pH-preferred DOX release profile.Attributing to the DOX/TPGS dual drug design,the(G5-TPGS@y-CDs)-DOX complexes can overcome the multidrug resistance(MDR)of cancer cells and effectively inhibit the growth of cancer cells and tumors.Furthermore,the introduction of US-targeted microbubble destruction technology was proven to render the complexes with enhanced intracellular uptake and anticancer efficacy in vitro and improved chemotherapeutic efficacy and fluorescence imaging of tumors in vivo due to the produced sonoporation effect.The developed multifunctional dendrimer/CD nanohybrids may represent an advanced design of nanomedicine for US-enhanced theranostics of different types of MDR tumors. | Dan Li Lizhou Lin Yu Fan Long Liu Mingwu Shen Rong Wu Lianfang Du Xiangyang Shi | 2021 | Bioactive Materials2021，6，3： | 3 |
| 6 | Coordinated Dispatch of Integrated Electricity-Natural Gas System and the Freight Railway Network显示文摘With the significant development of liquefied natural gas(LNG)rail transport,the railway system is increasingly more closely connected with the integrated electricity-natural gas system(IEGS).To coordinate the economic operations of the two systems,this paper innovatively proposes a coordinated dispatch model of IEGS with LNG infrastructures and a freight railway network with LNG transport.First,an operational scheduling model of the railway network,considering energy consumption,is put forward for both LNG transmission and ordinary freight transport.Then,the coordinated dispatch problem of IEGS and the railway network is formulated into a mixed-integer linear programming model via the big M method and a modified incremental linearization approach.Finally,a bi-level optimization algorithm based on generalized benders decomposition(GBD)is presented to solve the coordinated dispatch problem due to the restrictions on exchanging private information.Case studies demonstrate the effectiveness of the proposed model and algorithm as well as the potential benefit for wind power accommodation. | Tao Long Zhaohong Bie Lizhou Jiang Haipeng Xie | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 3 |
| 7 | A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus显示文摘To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus(IBDV), a pair of viruses, namely the moderately virulent IBDV(rG x-F9VP2) and the attenuated strain(rGt), were used. Residue mutations A222P(P_(BC)) and S330R(PHI), selected by sequence comparison, were introduced individually into r Gx-F9VP2 by using a reverse genetics system. In addition, the reverse mutation of either P222 A or R330 S was introduced into r Gt. The four modified viruses were then rescued and evaluated in vitro(CEF cells) and in vivo(SPF chickens). Results showed that A222 P elevated the replication efficiency of rG x-F9VP2 while P222 A reduced that of rG t in CEF cells. A mutation at residue 330 did not alter IBDV replication. In addition, animal experiments showed that a single mutation at either residue 222 or 330 did not significantly influence the virulence of IBDV. In conclusion, residue 222 in PBC of VP2 is involved in the replication efficiency of IBDV in vitro but does not affect its virulence in vivo, further facilitating our understanding of the gene-function of IBDV. | Xiaole Qi Xiang Gao Zhen Lu Lizhou Zhang Yongqiang Wang Li Gao Yulong Gao Kai Li Honglei Gao Changjun Liu Hongyu Cui Yanping Zhanga Xiaomei Wang | 2016 | Science China(Life Sciences)2016，59，7： | 2 |
| 8 | EFFECT OF OXIDIZED-LDL ON NF-κB NUCLEAR TRANSLOCATION IN AORTIC SMOOTH MUSCLE CELLS ORIGINATED FROM RATS OF DIFFERENT AGES显示文摘Objective To investigate the molecular mechanism of atherosclerosis that related to age. Methods Immunohistochemistry staining and Western blot were adopted to determine the nuclear translocation of nuclear factor-kappa B (NF-κB) and expression of platelet-derived growth factor B (PDGF-B) in smooth muscle cells (SMCs) co-cultured with low density lipoprotein (LDL), oxidized LDL (ox-LDL), and ox-LDL+high density lipoprotein (HDL) originated from rats of 2 and 10 months old respectively. Fat stain was used to identify the lipid intake in SMCs. Results The optimal stimulation time of ox-LDL to SMCs was 12 hours. NF-κB intensity increased in most nuclei of SMCs that originated from rats of either 2 or 10 months old co-cultured with ox-LDL. The intensity of NF-κB and the amount of intracellular lipid taken in SMCs were more obvious in cells from 10-month-old rats than from the younger ones. Change of PDGF-B expression in SMCs was not remarkable in each group of rats. Conclusions The 10-month-old rats are more susceptive to ox-LDL than 2-month-old rats in activating nuclear transloca- tion of NF-κB. Maybe this is one of the important reasons contributing to the difference between the older and younger rats on the initiation and development of atherosclerosis lesion. Expression of PDGF-B is not associated with the activity of nuclear translocation of NF-κB. | Jun-huaZhang LiZhou Hong-chaoYin Pei-maoLiu HuaZhang Ming-pengShe | 2005 | Chinese Medical Sciences Journal2005，20，2： | 2 |
| 9 | Heat Treatment of Modified 6005A Alloy for Vehicles显示文摘Modified 6005A alloy was reported and its mechanical properties were studied by tensile test, hardness measurement and TEM analysis. Results show that the favorable aging condition for 6005A is 175°Cfor 8h, and the nose temperature of its TTP (Time-temperature-properties) curves is about 370°C. In a moderate temperature zone (270°C | CAOLing-fei WANGMing-pu GUOMing-xing LIZhou | 2004 | 材料热处理学报2004，25，5： | 2 |
| 10 | Interaction between curcumin and mimetic biomembrane显示文摘Curcumin,a major bioactive compound in turmeric,has a broad spectrum of antioxidant,anticarcinogenic,antimutagenic and anti-inflammatory properties.At the molecular level,curcumin modulates many structurally unrelated membrane proteins through several signaling pathways.Curcumin has been suggested to change the properties of cell membranes and affect the membrane-bound proteins indirectly;however,the detailed mechanism has yet to be investigated.In this paper,self-assembled bilayer lipid membranes are artificially constructed on the surface of a gold electrode to mimic biomembranes,and interaction between the supported membranes and curcumin is studied electrochemically.Results show that curcumin interacts with the membranes strongly,in a concentration-dependent manner.At low concentrations,curcumin tends to insert into the outer monolayer only,while at high concentrations,it may also begin to penetrate the inner monolayer.The results obtained in this work may enhance our understanding of the effect of curcumin,and possibly flavonoids,on cell membranes and membrane proteins. | CHEN GuiFang CHEN YangYang YANG NaNa ZHU XueJun SUN LiZhou LI GenXi | 2012 | Science China(Life Sciences)2012，55，6： | 2 |
| 11 | Monitoring of regional drug abuse through wastewater-based epidemiology—A critical review显示文摘Wastewater-based epidemiology is a new approach to monitor drug abuse. It involves collecting wastewater, analysis of residues of drugs or its metabolites in wastewater, and back-calculation of drug consumption by taking into account wastewater flow, stability of drug target residues in wastewater, and excretion rates of drugs/metabolites. Wastewater-based epidemiology has the advantages of being inexpensive and yielding more consistent and near real-time results. It has the great potential to supplement the existing drug monitoring methods. It can be used to build large-scale(regional, national, or even continental) monitoring networks that would yield spatial patterns and temporal trends in drug abuse. This paper described in detail the principle and procedures of this wastewater-based approach. Application of this approach across the globe was also reviewed. The uncertainties involved in the approach and knowledge gaps were identified. Finally, necessity, benefits, and feasibility to set up nation or province-wide monitoring networks based on wastewater analysis in China were discussed. | Lizhou FENG Wei ZHANG Xiqing LI | 2018 | Science China Earth Sciences2018，61，3： | 2 |
| 12 | Two-dimensional LDH nanodisks modified with hyaluronidase enable enhanced tumor penetration and augmented chemotherapy显示文摘The condensed tumor extracellular matrix(ECM)consisting of cross-linked hyaluronic acid(HA)is one of the key factors that result in the aberrant tumor microenvironment and severely impair drug delivery and tumor penetration.Herein,we report a simple design of a hyaluronidase(HAase)-modified layered double hydroxide(LDH)nanoplatform loaded with anticancer drug doxorubicin(DOX)for enhanced tumor penetration and augmented chemotherapy.In our approach,LDH nanodisks were synthesized via a co-precipitation method,modified with HAase by electrostatic attraction,and finally physically loaded with DOX.The formulated DOX/LDH-HAase complexes show a high DOX loading percentage of 34.2%with good colloidal stability,retain 86.1%of the enzyme activity,and release DOX in a pH-responsive manner having a faster release rate under slightly acidic tumor microenvironment than that under a physiological condition.With the catalytic activity of HAase to digest the HA nearby the cancer cells,the developed DOX/LDH-HAase complexes enable more significant uptake by cancer cells and penetration in 3-dimensional tumor spheroids than enzyme-free DOX/LDH complexes,thus displaying much better antitumor efficacy in vitro than the latter.The more significant tumor penetration and inhibition of the DOX/LDH-HAase complexes than that of the DOX/LDH complexes was further demonstrated by in vivo tumor imaging and therapeutic activity assessments.Our study suggests a unique nanomedicine platform combined with both anticancer drug and enzyme for improved tumor penetration and chemotherapy,which is promising for effective chemotherapy of different types of stroma-rich tumors. | Gaoming Li Yu Fan Lizhou Lin Rong Wu Mingwu Shen Xiangyang Shi | 2021 | Science China Chemistry2021，64，5： | 2 |
| 13 | Fast CO_(2) Retrieval Using a Semi-Physical Statistical Model for the High-Resolution Spectrometer on the Fengyun-3D Satellite显示文摘China’s Fengyun-3D meteorological satellite launched in December 2016 carries the high-resolution greenhouse-gases absorption spectrometer(GAS)aimed at providing global observations of carbon dioxide(CO_(2)).To date,GAS is one of the few instruments measuring CO_(2) from the near-infrared spectrum.On orbit,the oxygen(O_(2))A band suffers a disturbance,and the signal-to-noise ratio(SNR)is significantly lower than the nominal specification.This leads to difficulties in the retrieval of surface pressure and hence a degradation of the retrieval of the column-averaged CO_(2) dry air mole fraction(XCO_(2))if a full physics retrieval algorithm is used.Thus,a fast CO_(2) inverse method,named semi-physical statistical algorithm,was developed to overcome this deficiency.The instrument characteristics,the semi-physical statistical algorithm,and the results of comparison with ground-based measurements over land were introduced in this paper.XCO_(2) can be obtained from three bands,namely,the O_(2) A,weak CO_(2),and strong CO_(2) bands,with compensation from the Medium Resolution Spectral Imager-2(MERSI-2)products,ECMWF Reanaly-sis v5(ERA-5)data,and Total Carbon Column Observing Network(TCCON)data.The eigenvectors of covariance matrices and the least square fits were used to derive retrieval coefficients and yield cloud-free solutions.In addition to the GAS radiance,some key factors necessary for the accurate estimations of XCO_(2) were also taken as input information(e.g.,air mass,surface pressure,and a priori XCO_(2)).The global GAS XCO_(2) restricted over land was compared against the simultaneously collocated observations from TCCON.The retrieval algorithm can mitigate the issue caused by the low SNR of the O_(2) A band to a certain extent.Overall,through site-by-site comparisons,GAS XCO_(2) agreed well with the average precision(1σ)of 1.52 ppm and bias of−0.007 ppm.The seasonal variation trends of GAS XCO_(2) can be clearly seen at TCCON sites on the 1-yr timescale. | Yanmeng BI Peng ZHANG Zhongdong YANG Qian WANG Xingying ZHANG Chengbao LIU Pengmei XU Lizhou HOU Junyu KE Naiqiang ZHANG | 2022 | Journal of Meteorological Research2022，36，2： | 2 |
| 14 | Dynamic Finite Element Modeling and Simulation of Soft Robots显示文摘Soft robots have become important members of the robot community with many potential applications owing to their unique flexibility and security embedded at the material level.An increasing number of researchers are interested in their designing,manufacturing,modeling,and control.However,the dynamic simulation of soft robots is difficult owing to their infinite degrees of freedom and nonlinear characteristics that are associated with soft materials and flexible geometric structures.In this study,a novel multi-flexible body dynamic modeling and simulation technique is introduced for soft robots.Various actuators for soft robots are modeled in a virtual environment,including soft cable-driven,spring actuation,and pneumatic driving.A pneumatic driving simulation was demonstrated by the bending modules with different materials.A cable-driven soft robot arm prototype and a cylindrical soft module actuated by shape memory alley springs inspired by an octopus were manufactured and used to validate the simulation model,and the experimental results demonstrated adequate accuracy.The proposed technique can be widely applied for the modeling and dynamic simulation of other soft robots,including hybrid actuated robots and rigid-flexible coupling robots.This study also provides a fundamental framework for simulating soft mobile robots and soft manipulators in contact with the environment. | Liang Ding Lizhou Niu Yang Su Huaiguang Yang Guangjun Liu Haibo Gao Zongquan Deng | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 2 |
| 15 | Research on clarification performance of mixing clarifying tank Ⅰ aiding clarification performance of filler (混合澄清性能的改进研究Ⅰ填料的助澄清性能)[J]显示文摘 | LIZhou(李洲) YANGZhi-hua(杨志华) TANShi-yu(谭世语) | 1986 | 稀有金属1986，，5： | 1 |
| 16 | Turbine blade temperature transfer using the load surface method 显示文摘 | Li Lizhou Lu Zhenzhou | 2007 | Computer- Aided Design2007，39，6： | 1 |
| 17 | Turbine blade temperature transfer using the load surface method 显示文摘 | Li Lizhou Lu Zhenzhou Wang Jingchao Yue Zhufeng | 2007 | Computer-Aided Design2007，39，6： | 1 |
| 18 | Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case–control study in China显示文摘 | Lian‐YuanTao Xiao‐DongHe QiangQu LeiCai WeiLiu LiZhou Shang‐MingZhang | 2009 | Liver International2009，，2： | 1 |
| 19 | Large deflection problem of a clamped elliptical plate subjected to uniform pressure显示文摘 | Chien Weizang Pan Lizhou Liu Xiaoming | 1991 | Applied Mathematics and Me- chanics1991，3，10： | 1 |
| 20 | 3D DNA origami designed with caDNAno显示文摘For about three decades, DNA-based nanotechnology has been undergoing development as an assembly method for nanostructured materials. The DNA origami method pioneered by Rothemund paved the way for the formation of 3D structures using DNA self assembly. The origami approach uses a long scaffold strand as the input for the self assembly of a few hundred staple strands into desired shapes. Herein, we present a 3D origami 'roller' (75 nm in length) designed using caDNAno software. This has the potential to be used as a template to assemble nanoparticles into different pre-defined shapes. The 'roller' was characterized with agarose gel electrophoresis, atomic force microscopy (AFM) and transmission electron microscopy (TEM). | AMOAKO George ZHOU Ming YE RiAn ZHUANG LiZhou YANG XiaoHong SHEN ZhiYong | 2013 | Chinese Science Bulletin2013，58，24： | 1 |
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