|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，10： | 84 |
| 2 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 3 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 4 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 5 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 6 | The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China显示文摘Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous. | Li Jinyi, He Zhengjun, Mo Shenguo and (Institute of Geology, CAGS, Beijing 100037, China) Zheng Qingdao (Heilongjiang Bureau of Exploration and Exploitation of Geology and M ineral Resources, Ha’erbin 150036, China) | 1999 | Global Geology1999，4，2： | 26 |
| 7 | 中韩河流沉积物微量元素地球化学研究显示文摘长江和黄河以及韩国的Keum和Yeongsan江,具有不同的微量元素地球化学特征。韩国河流沉积物中微量元素含量多介于长江和黄河之间,以Li、Rb和Th较高为特征,粒级效应明显。长江富铁族和铜族元素,黄河则Sr最高,其他元素均低于其他3条河流;韩国河流中Sr主要赋存于长石中,而长江和黄河中则主要赋存于碳酸盐矿物中。根据沉积物中元素的赋存相态及含量,我们认为Ti、Cr/Th、Ti/Nb和Zr/Nb等可以作为判别西太平洋边缘海,尤其是黄海中长江、黄河与韩国河流物质贡献的可靠地球化学参数,但在运用中必须注意粒级效应影响。 | 杨守业 李从先 JUNG Hoi-soo LI M Dong-il CHOI Man-sik | 2003 | 海洋地质与第四纪地质2003，23，2： | 24 |
| 8 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 9 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 10 | Spatial-temporal Pattern and Population Driving Force of Land Use Change in Liupan Mountains Region, Southern Ningxia, China显示文摘The Liupan Mountains is located in the southern Ningxia Hui Autonomous Region of China, which forms an important dividing line between landforms and bio-geographic regions. The populated part of the Liupan Mountains region has suffered tremendous ecological damages over time due to population pressure, excessive demand and inappropriate use of agricultural land resources. In this paper, datasets of land use between 1990 and 2000 were obtained from Landsat TM imagery, and then spatial models were used to characterize landscape conditions. Also, the relationship between the population density and land use/cover change (LUCC) was analyzed. Results indicate that cropland, forestland, and urban areas have increased by 44,186ha, 9001ha and 1550ha, respectively while the grassland area has appreciably decreased by 54,025ha in the study period. The decrease in grassland was most notable. Of the grassland lost, 49.4% was converted into cropland. The largest annual land conversion rate in the study area was less than 2%. These changes are attributed to industrial and agricultural development and population growth. To improve the eco-economic conditions in the study region, population control, urbanization and development of an ecological friendly agriculture were suggested. | QUAN Bin M J M ROMKENS TAO Jianjun LI Bicheng LI Chaokui YU Guanghui CHEN Qichun | 2008 | Chinese Geographical Science2008，18，4： | 15 |
| 11 | 功能的限制的积极选择而非松驰在鸡驯服期间驾驶视觉的进化显示文摘是由达尔文,注意了鸡有所有鸟,而是国内鸡和他们的野祖先之间的有趣的进化差别的最大的 phenotypic 差异,红 Junglefowl,是他们的比较地更弱的视觉。存在理论建议在国内鸡之中的减少的视觉英勇反映功能的限制的松驰在识别负责的内在的基因机制的视觉,而是证据上驾驶的变化因为这个变化决定性地没被描绘。这里,国内鸡的染色体宽的分析和红 Junglefowl 染色体为涉及视觉的发展的断然选择的基因显示出重要丰富。关于为在视网膜的这些基因的 mRNA 表示的水平国内鸡和他们的野祖先之间有重要差别。涉及视觉的发展的众多的另外的基因也在在国内鸡和他们的野祖先之间的 mRNA 表示显示出重要差别,特别地为与 phototransduction 和光敏电阻器开发联系的基因,例如 RHO (视紫红质) , GUCA1A, PDE6B 和 NR2E3。最后,我们在视觉描绘了 VIT 基因的潜在的角色,它在村庄鸡的视网膜经历了积极选择和 downregulated 表示。总的来说,我们的结果建议净化选择的那种积极选择,而非松驰,在国内鸡贡献了视觉的进化。怀有更弱的视觉的国内鸡的祖先可能显示出减少的害怕回答和警戒,使他们更安逸无意识地被选择或驯养。 | Ming-Shan Wang Rong-wei Zhang Ling-Yan Su Yah Li Min-Sheng Peng He-Qun Liu Lin Zeng David M Irwin Jiu-Lin Du Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang | 2016 | Cell Research2016，26，5： | 15 |
| 12 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 13 | Increase of beta-amyloid and C-reactive protein in liver transplant recipients with postoperative cognitive dysfunction显示文摘BACKGROUND: Postoperative cognitive dysfunction (POCD) is an adverse condition characterized by declined cognitive functions following surgeries and anesthesia. POCD has been associated with increased hospital stay and mortality. There are histological similarities to Alzheimer's disease. Most early studies were conducted in patients receiving cardiac surgery. Since there is no information about POCD in liver transplant recipients, we measured the incidence of POCD in patients after liver transplantation and examined the correlation between neurological dysfunction and biological markers of dementia- based diseases. METHODS: We studied 25 patients who had a liver transplan- tation between July 2008 and February 2009. Patients with prior encephalopathy or risk factors associated with the development of POCD were excluded from the study. Five validated neuropsychiatric tests were used for diagnosis. The diagnosis was based on one standard deviation decline in two of the five neuropsychiatric tests. The correlation between patient variables and the development of POCD was examined. Serum levels of beta-amyloid and C-reactive protein were measured by standard ELISA and compared between patients with and without POCD. RESULTS: POCD was present in 11 (44%) of the 25 patients. Patients with POCD had significantly higher MELD scores, were more often Child-Pugh class C and received more blood transfusion during surgery. The serum beta-amyloid protein and C-reactive protein concentrations were significantly increased at 24 hours after surgery in the POCD group.CONCLUSIONS: The incidence of POCD in our group of liver transplant patients was greater than that reported in other surgical patients. The increase in the serum biomarkers of dementia in the POCD patients supports the hypothesis that chronic cognitive defects are due to a process similar to that seen in Alzheimer's disease. | Xing Li Da-Xiang Wen Yan-Hong Zhao Yan-Nan Hang M Susan Mandell | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 13 |
| 14 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 15 | Epigallocatechin-3-gallate (EGCG) attenuates nflammation in MRL/Ipr mouse mesangial cells显示文摘 | Abigail Peairs Rujuan Dai Lu Gan Samuel Shimp M Nichole Rylander Liwu Li Christopher M Reilly | 2010 | Cellular & Molecular Immunology2010，7，2： | 12 |
| 16 | Effects of Topography and Land Use Change on Gully Development in Typical Mollisol Region of Northeast China显示文摘Due to high intensity agricultural exploitation since the middle of the 20 th century, farmland gullies have become a pervasive form of water erosion in Northeast China. Yet few researches are concentrated on how topography and land use affect long-term gully development in this region. In this study, gully distribution in a village with an area of 24.2 km^2 in the central Mollisols area of Northeast China in different times were compared by Aerial photography(1968), Quickbird image(2009) and field survey, and factors affecting gully development including land use and topography were analyzed. The results showed that the total gully number decreased from 104 to 69, while occupying area rose from 34.8 ha to 78.4 ha from 1968 to 2009. Fundamental gully distribution had been formed by 1968 as most of 2009′s gullies were evolved from 1968′s gullies′ merge and width expansion process, and new gullies those initiated after 1968 occupied only 7% of total gully area in 2009. Gully area increasing ratio in grassland was the highest and that in forestland was the lowest. The threshold catchment area between simple and complex gully development was around 15 ha to 25 ha. This threshold value sets apart catchment areas that will develop simple or complex gullies in areas with similar environmental conditions. Gully control measurements were urgent because if appropriate gully control implements would not be applied, present gully erosion crisis could be doubled within 50 years. | LI Hao Richard M CRUSE LIU Xiaobing ZHANG Xingyi | 2016 | Chinese Geographical Science2016，26，6： | 11 |
| 17 | Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro显示文摘To determine the chemical composition of Galla chinensis extract(GCE) by several analysis techniques and to compare the efficacy of GCE and its main component(s) in inhibition of enamel demineralization,for the development of future anticaries agents,main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry(LC-TOF-MS) and quantified by high-performance liquid chromatography-diode array detector(HPLC-DAD).Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography.Then,bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times.Each cycle included 5-min applications with one of four treatments:4 g?L 21 GCE solution,4 g?L 21 gallic acid(GA) solution,1 g?L 21 NaF solution(positive control),deionized water(DDW,negative control),and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer.Acidic buffers were retained for calcium analysis.The main organic composition of GCE were GA and its isomer,and,to a lesser extent,small molecule gallotannins.The content of GA in GCE was 71.3%60.2%(w/w).Inorganic ions were present in various amounts,of which Ca was(13662.82) mg?g 21,and Zn was(6.860.1) mg?g 21.No F was detected in GCE.In pH cycling,GA showed an effect similar to GCE in inhibiting enamel demineralization(P.0.05).GA was found to be the main effective,demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents. | Xue-Lian Huang Ming-Dong Liu Ji-Yao Li Xue-Dong Zhou Jacob M ten Cate | 2012 | International Journal of Oral Science2012，4，3： | 11 |
| 18 | Temperature variations inside Chinese solar greenhouses with external climatic conditions and enclosure materials显示文摘Chinese solar greenhouses enable the extension of the crop growing season in the cold climate in Northern China with little or no additional heating.The temporal variations of the air temperatures inside solar greenhouses located at three cities in North,Northeast and Northwest China were predicted by CFD simulations of the greenhouse systems using typical meteorological data.The predicted temperatures based on the meteorological data in Shenyang are quite similar to the measured temperatures.The results also show that the external air temperatures and solar radiation fluxes play more important roles for the inside temperatures as indicated by the highest inner temperature in the morning on Feb.18 and from 10:00 to 14:00 on Feb.19 in Beijing and by the predicted temperatures inside the greenhouse being higher in Lanzhou than those in Shenyang and Beijing during most of the day.The average daily temperature inside the greenhouse in Lanzhou was nearly 3.5℃higher than that in Shenyang.Predicted air temperatures for various wall designs show that for single walls,the daily average interior temperatures in the aerated concrete wall greenhouse were higher than those in the brick wall and reinforced concrete wall greenhouses.However,the air temperature fluctuations were lower in the reinforced concrete wall greenhouse due to greater thermal storage capacity.The results also show that the temperatures in the layered wall greenhouses are quite similar,which coincides with the experimental results。 | Tong Guohong David M Christopher Li Tianlai Wang Tieliang | 2008 | International Journal of Agricultural and Biological Engineering2008，1，2： | 10 |
| 19 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 20 | Synthesis of bis(amine anhydride)s for novel high Tgs and organosoluble poly(amine imide) s by palladium-catalyzed amination of 4-chlorophthalide anhydride 显示文摘 | Li W M Li S H Zhang Q Y | 2007 | Macromolecules2007，40，： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员