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| 1 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 2 | Projection micro stereolithography based 3D printing and its applications显示文摘Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering multiple scales and with multiple materials.This paper reviews the recent development of the PμSL based 3D printing technologies,together with the related applications.It introduces the working principle,the commercialized products,and the recent multiscale,multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to PμSL.This review paper also summarizes a few typical applications of PμSL including mechanical metamaterials,optical components,4D printing,bioinspired materials and biomedical applications,and offers perspectives on the directions of the further development of PμSL based 3D printing technology. | Qi Ge Zhiqin Li Zhaolong Wang Kavin Kowsari Wang Zhang Xiangnan He Jianlin Zhou Nicholas X Fang | 2020 | International Journal of Extreme Manufacturing2020，2，2： | 11 |
| 3 | 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC. | Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 7 |
| 4 | Spatial-temporal patterns of vegetation dynamics and their relationships to climate variations in Qinghai Lake Basin using MODIS time-series data显示文摘全球温暖在最近的年里导致了重要植被变化。为环境适应的更好的理解在植被变化上调查气候的变化(温度和降水) 的效果到气候的变化是必要的。在这份报纸,我们在 GIS 集中了于多方法和空间分析技术的集成和申请学习植被动力学的时间空间的变化并且探索植被变化机制。在在不同时间规模的 EVI 和气候因素之间的关联在从 2001 ~ 2012 的一年的金海·莱克盆分别地为包括每月、季节、年度的规模的每个象素是计算的。这研究的主要目的是揭示什么时候,植被变化在哪儿并且为什么练习以便为明智的地区性的生态系统管理支持对全球变化以及有用信息和技术的陆上的反应的更好的理解。主要结论如下:(1 ) 在这个区域的全面植被 EVI 增加了 6% 在期间最近 12 年。在种季节的 EVI 价值(即春天和夏天) 展出了很重要的改善趋势,分别地占了 12.8% 和 9.3% 。EVI 的空间模式看明显的空间异质哪个与热水的状况一致。一般来说,自从将近 78% 象素整个盆显示出增加的趋势,植被范围在区域的大多数部分改善了,当仅仅在区域的小部分稍微降级了时。(2 ) EVI 变化断然与平均温度和降水被相关。一般来说在金海·莱克盆,降水是为植被生长的主导的开车因素;然而,在不同时间规模,它到植被的重量有差别。(3 ) 基于 geo 统计的分析,秋天降水在整个区域与下一春天 EVI 价值有强壮的关联。这调查结果探索秋天降水是重要指示物,然后,限制下个弹簧的植物生长。 | GUO Weit NI Xiangnan JING Duanyang LI Shuheng | 2014 | Journal of Geographical Sciences2014，24，6： | 6 |
| 5 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 6 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 7 | Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications显示文摘Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive applications.Borophene,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical applications.However,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties.In this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal properties.The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication.In the end,the challenges of borophene in the latest applications are presented and perspectives are discussed. | Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang | 2020 | Research2020，，1： | 2 |
| 8 | Hydrodynamic behavior of liquid-solid micro-fluidized beds determined from bed expansion显示文摘 | Xiangnan Li Mingyan Liu Yanjun Li | 2018 | Particuology2018，16，3： | 2 |
| 9 | The assimilation of spectral sensing and the WOFOST model for the dynamic simulation of cadmium accumulation in rice tissues显示文摘 | Ling Wu Xiangnan Liu Ping Wang Botian Zhou Meiling Liu Xuqing Li | 2013 | International Journal of Applied Earth Observations and Geoinformation2013，，： | 1 |
| 10 | 显示文摘 | Li Xiangnan Chen Xiaoming Peng Zhiming | 2011 | Journal of Functional Materials2011，42，2： | 1 |
| 11 | Neural-network model for estimating leaf chlorophyll concentration in rice under stress from heavy metals using four spectral indices 显示文摘 | LIU Meiling LIu Xiangnan LI Mi FANG Meihong Cm Wenxue | 2010 | Biosystems Engineering2010，106，3： | 1 |
| 12 | Effects of Severe Cold Rolling on Exfoliation Corrosion Behavior of Al-Zn-Mg-Cu-Cr Alloy 显示文摘 | Lianghua Lin Zhiyi Liu Yao Li Xiangnan Han Xu Chen | 2012 | ASM International2012，，2012： | 1 |
| 13 | In-situ observation and modeling approach to evolution of pore-fracture structure in coal显示文摘The characterisation of the pore-fracture structure(PFS)and its evolution in coal during mining are essential for preventing gas outbursts and improving gas extraction efficiency.In this study,the evolution of the PFS in coal samples under the condition of mining stress was directly captured in situ by combination of the mechanical testing system with high-precision visualisation nuclear magnetic resonance equipment.A fractional derivative model was established to describe the relationship between stress and porosity based on experimental results of the PFS under different stress states.The results showed that with an increase in the deviatoric stress,the adsorption pore content increases rapidly initially and then increases slowly or remains unchanged;the seepage pore and fracture(SPF)content decreases initially and then increases.The SPF compressibility coefficient decreases with an increase in the deviatoric stress.The fractional derivative model can accurately describe the stress sensitivity of the SPFs at the pre-peak stage,thus providing a new approach for accurately characterising the seepage characteristics of coal reservoirs. | Hongwei Zhou Zelin Liu Jiawei Zhao Bocen Chen Xiangnan Li Jiangcheng Zhong | 2023 | International Journal of Mining Science and Technology2023，33，3： | 1 |
| 14 | Integrating spectral indices with environmental parameters for estimating heavy metal concentrations in rice using a dynamic fuzzy neural-network model显示文摘 | Meiling Liu Xiangnan Liu Menxin Wu Lufeng Li Lina Xiu | 2011 | Computers and Geosciences2011，，10： | 1 |
| 15 | A novel Puroindoline b-2 variant present in Chinese winter wheat cultivar Yunong 202显示文摘 | Feng Chen Huanhuan Li Xiaoli Shang Xiangnan Li Dangqun Cui | 2012 | Journal of Cereal Science2012，，： | 1 |
| 16 | Hydrogel-elastomer-based stretchable strain sensor fabricated by a simple projection lithography method显示文摘Stretchable strain sensor detects a wide range of strain variation and is therefore a key component in various applications.Unlike traditional ones made of elastomers doped with conductive components or fabricated with liquid conductors,ionically conductive hydrogel-based strain sensors remain conductive under large deformations and are biocompatible.However,dehydration is a challenging issue for the latter.Researchers have developed hydrogel-elastomer-based strain sensors where an elastomer matrix encapsulates a hydrogel circuit to prevent its dehydration.However,the reported multistep approaches are generally time-consuming.Our group recently reported a multimaterial 3D printing approach that enables fast fabrication of such sensors,yet requires a self-built digital-light-processing-based multimaterial 3D printer.Here,we report a simple projection lithography method to fabricate hydrogel-elastomer-based stretchable strain sensors within 5 minutes.This method only requires a UV projector/lamp with photomasks;the chemicals are commercially available;the protocols for preparing the polymer precursors are friendly to users without chemistry background.Moreover,the manufacturing flexibility allows users to readily pattern the sensor circuit and attach the sensor to a 3D printed soft pneumatic actuator to enable strain sensing on the latter.The proposed approach paves a simple and versatile way to fabricate hydrogel-elastomer-based stretchable strain sensors and flexible electronic devices. | Zhenqing Li Xiangnan He Jianxiang Cheng Honggeng Li Yuan-Fang Zhang Xiaojuan Shi Kai Yu Hui Ying Yang Qi Ge | 2021 | International Journal of Smart and Nano Materials2021，12，3： | 1 |
| 17 | An amplitude adaptive notch filter for grid signal processing显示文摘 | Yin Guiliang Guo Lei Li Xiangnan | 2013 | IEEE Transactions on Power Electronics2013，28，6： | 1 |
| 18 | Computer Aided Design Technology for Convex Faceted Gem Cuts Based on the Half-Edge Data Structure显示文摘Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration. | Linhong Xu Xiangnan Li Jianhua Rao Yuan Han Zhipeng Li Jichun Li | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 1 |
| 19 | Molecular characterization of secaloindoline genes in introduced CIMMYT primary hexaploid triticale显示文摘In order to widen gene germplasm for kernel hardness in triticale, 60 synthetic hexaploid triticales were tested by the single kernel characterization system(SKCS) and secaloindoline alleles were identified by sequencing. Phenot^ing showed that frequencies of soft, mixed and hard genotypes were 43.3%, 48.3%, and 8.4%, respectively. Genotyping identified three known secaloindoline-a alleles and four known secaloindoline-b alleles. Three new Sina-Rl alleles were designated Sina-Rld, Sina-Rle and Sina-Rlf. Compared to Sina-Dlc, Sina-Rld showed four point mutations causing changes in four amino acids, Sina-Rle had one point mutation causing an alanine to glycine substitution, and Sina-Rlf possessed five point mutations but produced the same amino add sequence as Sina-Rld. Two new Sinb-Rl alleles were discovered and designated Sinb-Rle and Sinb-Rl/. Compared to Sinb-Rla, Sinb-Rle possessed a triplet-code insertion and four point mutations causing a cysteine insertion and two amino acid substitutions, and Sinb-Rl/possessed three point mutations causing a cysteine insertion and a change of arginine to glycine.Association of hardness index with secaloindoline alleles indicated t±iat SKCS of the Sina-Rld genotype was significantly lower than that of Sina-Rle, and Sinb-Rle was significantly lower than that of the Sinb-Rld genotype. A total of eight allelic combinations of secaloindoline genes were identified; Sma-Rld/Sinb-Rle and Sina-Rle/Sinb-Rld were relatively prevalent in the triticales surveyed. The results provide valuable information for further use of these germplasms in triticale breeding program due to the diverse polymorphism in secaloindoline genes. | Hongmei Liu Xiaobian Zhou Xiangnan Li Junying Chen Dangqun Cui Feng Chen | 2017 | The Crop Journal2017，5，5： | 1 |
| 20 | ABA-mediated regulation of leaf and root hydraulic conductance in tomato grown at elevated CO2 is associated with altered gene expression of aquaporins显示文摘Elevated CO_(2)concentration in the air(e[CO_(2)])decreases stomatal density(SD)and stomatal conductance(gs)where abscisic acid(ABA)may play a role,yet the underlying mechanism remains largely elusive.We investigated the effects of e[CO_(2)](800 ppm)on leaf gas exchange and water relations of two tomato(Solanum lycopersicum)genotypes,Ailsa Craig(WT)and its ABA-deficient mutant(flacca).Compared to plants grown at ambient CO_(2)(400 ppm),e[CO_(2)]stimulated photosynthetic rate in both genotypes,while depressed the gs only in WT.SD showed a similar response to e[CO_(2)]as gs,although the change was not significant.e[CO_(2)]increased leaf and xylem ABA concentrations and xylem sap pH,where the increases were larger in WT than in flacca.Although leaf water potential was unaffected by CO_(2)growth environment,e[CO_(2)]lowered osmotic potential,hence tended to increase turgor pressure particularly for WT.e[CO_(2)]reduced hydraulic conductance of leaf and root in WT but not in flacca,which was associated with downregulation of gene expression of aquaporins.It is concluded that ABA-mediated regulation of gs,SD,and gene expression of aquaporins coordinates the whole-plant hydraulics of tomato grown at different CO_(2)environments. | Liang Fang Lamis Osama Anwar Abdelhakim Josefine Nymark Hegelund Shenglan Li Jie Liu Xiaoying Peng Xiangnan Li Zhenhua Wei Fulai Liu | 2019 | Horticulture Research2019，6，1： | 1 |
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