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| 1 | Preliminary assessment of the navigation and positioning performance of BeiDou regional navigation satellite system显示文摘BeiDou regional navigation satellite system(BDS)also called BeiDou-2 has been in full operation since December 27,2012.It consists of 14 satellites,including 5 satellites in Geostationary Orbit(GEO),5 satellites in Inclined Geosynchronous Orbit(IGSO),and 4 satellites in Medium Earth Orbit(MEO).In this paper,its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing,including satellite visibility,Position Dilution of Precision(PDOP)value,the precision of code and carrier phase measurements,the accuracy of single point positioning and differential positioning and ambiguity resolution(AR)performance,which are also compared with those of GPS.It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm,respectively,which are comparable to those of GPS,and the accuracy of BDS single point positioning has satisfied the design requirement.The real-time kinematic positioning is also feasible by BDS alone in the opening condition,since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS.The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km,which is on the same level with that of GPS.For the combined BDS and GPS,the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly.The accuracy of BDS/GPS carrier phase differential positioning is about 35 and 20%better than that of GPS for two short baseline tests in this study.The accuracy of BDS code differential positioning is better than 2.5 m.However it is worse than that of GPS,which may result from large code multipath errors of BDS GEO satellite measurements. | YANG YuanXi LI JinLong WANG AiBing XU JunYi HE HaiBo GUO HaiRong SHEN JunFei DAI Xian | 2014 | Science China Earth Sciences2014，57，1： | 125 |
| 2 | Resource diversity of Chinese macrofungi:edible,medicinal and poisonous species显示文摘The huge land areas in China provide highly diverse habitats for macrofungi.Of these macrofungi,many are directly related to people’s daily life and have been utilized by ancient Chinese for at least 6800 years.In this study,we evaluate the current known resource diversity of Chinese macrofungi.A total of 1662 taxa are summarized,and all species names and their authorities have been checked and corrected according to authentic mycological databases.Among the 1662 taxa,1020,692,and 480 are considered to be edible,medicinal and poisonous mushrooms,respectively.A few of edible macrofungi in China are commonly used for commercial production.All known medicinal functions are labeled for medicinal species.The most common medicinal functions possessed by Chinese macrofungi are antitumor or anticancer,followed by antioxidant and antimicrobial.A total of 277 Chinese macrofungi are edible simultaneously with certain medicinal functions and without known toxicity.These species could be treated as“Gold Mushrooms”.Contrarily,193 edible and/or medicinal species are also recognized as poisonous mushrooms.To avoid poisoning caused by these species,ingestion either in a proper way or in small amounts is important.However,the mycotoxins metabolized by these poisonous species could be a huge wealth of natural products yet to be explored.How to utilize these Chinese macrofungal resources is a critical to benefit humans worldwide. | Fang Wu Li-Wei Zhou Zhu-Liang Yang Tolgor Bau Tai-Hui Li Yu-Cheng Dai | 2019 | Fungal Diversity2019，，5： | 81 |
| 3 | Prevalence of fatty liver disease and the economy in China: A systematic review显示文摘AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in China's Mainland. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to crosssectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product(GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models. RESULTS: There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73%(95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country(adjusted R2 = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas(R2 = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28%(95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1%(95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82(95%CI: 17.94%-25.71%) vs 17.01%(95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year. CONCLUSION: This study reveals a correlation between the economy and the prevalence of FLD in China's Mainland. | Jin-Zhou Zhu Qin-Yi Zhou Yu-Ming Wang Yi-Ning Dai Jiang Zhu Chao-Hui Yu You-Ming Li | 2015 | World Journal of Gastroenterology2015，21，18： | 116 |
| 4 | Magnetostratigraphy of the late Cenozoic Laojunmiao anticline in the northern Qilian Mountains and its implications for the northern Tibetan Plateau uplift显示文摘Cenozoic sediments in the foreland basin--Jiuquan Basin in west Hexi Corridor recorded tectonic uplift information of the Qilian Mountains. High resolution paleomagnetic dating of the Laojunmiao (LJM) section across the central LJM anticline in the southern Jiuquan Basin reveals ages of the Getanggou Member, Niugetao Member in the Shulehe Formation, the Yumen Conglomerate, Jiuquan Conglomerate and Gobi Formation at >13-8.3 Ma, 8.3-4.9 Ma, 3.66-0.93 Ma, 0.84-0.14 Ma and 0.14-0 Ma, respectively. Sedimentary evolution study suggests that the Qilian Mountains should begin to rise gradually since ~8-6.6 Ma, accompanied by sedimentary environments changing from lacustrine mudstones-sandstones to alluvial conglomerates. Rapid uplift of the Qilian Mountains began at ~3.66 Ma, followed by a series of stepwise or intermittent intensive uplifts at about <1.8-1.23 Ma, 0.93-0.84 Ma and 0.14 Ma, which finally resulted in the present high Qilian Mountains. | FANG Xiaomin1,2, ZHAO Zhijun3,2, LI Jijun2, YAN Maodu2, PAN Baotian2, SONG Chunhui2 & DAI Shuang2 1. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China 2. Key Laboratory of Western China’s Environmental Systems, Ministry of Education & College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 3. College of Geography, Nanjing Normal University, Nanjing 210097, China | 2005 | Science China Earth Sciences2005，48，7： | 61 |
| 5 | A nationwide survey of diabetes education, self-management and glycemic control in patients with type 2 diabetes in China显示文摘 | GUO Xiao-hui YUAN Li LOU Qing-qing SHEN Li SUN Zi-lin ZHAO Fang DAI Xia HUANG Jin YANG Hui-ying | 2012 | Chinese Medical Journal2012，，23： | 74 |
| 6 | Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer显示文摘The successes achieved by chimeric antigen receptor-modified T(CAR-T) cells in hematological malignancies raised the possibility of their use in non-small lung cancer(NSCLC). In this phase I clinical study(NCT01869166), patients with epidermal growth factor receptor(EGFR)-positive(>50% expression), relapsed/refractory NSCLC received escalating doses of EGFR-targeted CAR-T cell infusions. The EGFR-targeted CAR-T cells were generated from peripheral blood after a 10 to 13-day in vitro expansion. Serum cytokines in peripheral blood and copy numbers of CAR-EGFR transgene in peripheral blood and in tissue biopsy were monitored periodically. Clinical responses were evaluated with RECIST1.1 and immune-related response criteria, and adverse events were graded with CTCAE 4.0. The EGFR-targeted CAR-T cell infusions were well-tolerated without severe toxicity. Of 11 evaluable patients, two patients obtained partial response and five had stable disease for two to eight months. The median dose of transfused CAR+ T cells was 0.97×10~7 cells kg^(-1)(interquartile range(IQR), 0.45 to 1.09×10~7 cells kg^(-1)). Pathological eradication of EGFR positive tumor cells after EGFR-targeted CAR-T cell treatment can be observed in tumor biopsies, along with the CAR-EGFR gene detected in tumor-infiltrating T cells in all four biopsied patients. The EGFR-targeted CAR-T cell therapy is safe and feasible for EGFR-positive advanced relapsed/refractory NSCLC. | Kaichao Feng Yelei Guo Hanren Dai Yao Wang Xiang Li Hejin Jia Weidong Han | 2016 | Science China(Life Sciences)2016，59，5： | 62 |
| 7 | Isotopic evidence of TSR origin for natural gas bearing high H_2S contents within the Feixianguan Formation of the northeastern Sichuan Basin, southwestern China显示文摘The northeastern area of Sichuan Basin, southwestern China, is the area with the maximal reserve of natural gas containing higher hydrogen sulphide (H2S) that has been found among the petroliferous basins of China, with the proven and controlled gas reserve of more than 200 billion cubic meters. These gas pools, with higher H2S contents averaging 9%, some 17%, are mainly distributed on structural belts of Dukouhe, Tieshanpo, Luojiazhai, Puguang, etc., while the oolitic-shoal dolomite of the Triassic Feixianguan Fm. (T1f) is the reservoir. Although many scholars regard the plentiful accumulation of H2S within the deep carbonate reservoir as the re-sult of Thermochemical Sulfate Reduction (TSR), however, the process of TSR as well as its residual geological and geochemical evidence is still not quite clear. Based on the carbon iso-topic analysis of carbonate strata and secondary calcite, etc., together with the analysis of sulfur isotopes within H2S, sulphur, gypsum, iron pyrites, etc., as well as other aspects including the natural gas composition, carbon isotopes of hydrocarbons reservoir petrology, etc., it has been proved that the above natural gas is a product of TSR. The H2S, sulphur and calcite result from the participation of TSR reactions by hydrocarbon gas. During the process for hydrocarbons be-ing consumed due to TSR, the carbons within the hydrocarbon gas participate in the reactions and finally are transferred into the secondary calcite, and become the carbon source of secon-dary calcite, consequently causing the carbon isotopes of the secondary calcite to be lower (?18.2‰). As for both the intermediate product of TSR, i.e. sulfur, and its final products, i.e. H2S and iron pyrites, their sulfur elements are all sourced from the sulfate within the Feixianguan Fm. During the fractional processes of sulfur isotopes, the bond energy leads to the 32S being re-leased firstly, and the earlier it is released, the lower δ 34S values for the generated sulphide (H2S) or sulfur will be. However, for the anhydrite that participates in reactions, the higher the reaction degree, the more 32S is released, while the less 32S remains and the more δ 34S is increased. The testing results have proved the process of the dynamic fractionation of sulfur isotopes. | ZHU Guangyou ZHANG Shuichang LIANG Yingbo DAI Jinxing LI Jian | 2005 | Science China Earth Sciences2005，48，11： | 58 |
| 8 | Organochlorine compounds and polycyclic aromatic hydrocarbons in surface sediment from Baiyangdian Lake,North China:Concentrations,sources profiles and potential risk显示文摘Organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polycyclic aromatic hydrocarbons(PAHs) were determined in nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river(Fuhe River) in North China.Total concentrations of OCPs,PCBs and PAHs in sediments ranged from 5.4 to 707.6 ng/g,2.3 to 197.8 ng/g,and 101.3 to 6360.5 ng/g,respectively.The levels of contaminants in Fuhe River were significantly higher than those in Baiyandian Lake.For hexachlorocyclohexane(HCHs) and dichlorodiphenytrichloroethanes(DDTs),α-HCH and p,p-DDT were predominant isomers;while for PCBs,PCB 28/31,PCB 40/103,PCB 60,PCB 101,and PCB 118 were predominant congeners.Possible sources derived from historical usage for OCPs and incomplete combustion fuel,wood,and coal and exhaustion of boats or cars for PAHs.Risk assessment of sediment indicated that sediments in Fuhe River were likely to pose potential biological adverse impact. | Guocheng Hu Xiaojun Luo Fengchao Li Jiayin Dai Jianyang Guo Shejun Chen Cao Hong Bixian Mai Muqi Xu | 2010 | Journal of Environmental Sciences2010，22，2： | 42 |
| 9 | Anatomical distribution of pelvic deep infiltrating endometriosis and its relationship with pain symptoms显示文摘背景子宫内膜增生是渗入子宫内膜增生的争论、神秘的 disease.Deep (死)为痛苦的症状负责并且是 endometriosis.Little 工作的最少的理解的类型被奉献了定义地点死有 pain.The 的损害和它的关系学习瞄准是调查在解剖分发之间的关系死损害和疼痛 symptoms.Methods 从在2003年5月和2007年12月与之间的 354 个病人的临床的数据 | Dai Yi Leng Jin-hua Lang Jing-he Li Xiao-yan Zhang Jun-ji | 2012 | Chinese Medical Journal2012，，2： | 43 |
| 10 | Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-KB signaling pathway and activating the PI3K/Akt/Nrf2 pathway显示文摘 | Si-tong LI Qi DAI Shu-xian ZHANG Ya-jun LIU Qiu-qiong YU Fei TAN Shu-hong LU Quan WANG Jian-wen CHEN He-qing HUANG Pei-qing LIU Min LI | 2018 | Acta Pharmacologica Sinica2018，39，8： | 43 |
| 11 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 12 | Origins of High H_2S-bearing Natural Gas in China显示文摘Natural gas containing hydrogen sulphide (H2S) has been found in several petroliferous basins in China, such as the Sichuan Basin, Bohai Bay Basin, Ordos Basin, Tarim Basin, etc. Natural gas with higher H2S contents (H2S >5 % mol.) is mostly distributed in both the gas reservoirs of Dukouhe, Luojiazhai, Puguang and Tieshanpo, which belong to the Triassic Feixianguan Formation in the northeastern Sichuan Basin and those of the Kongdian-Shahejie formations in the northeastern Jinxian Sag of the Jizhong Depression, Bohai Bay Basin. In the Sichuan Basin, the H2S contents of natural gas average over 9% and some can be 17 %, while those of the Bohai Bay Basin range from 40 % to 92 %, being then one of the gas reservoirs with the highest H2S contents in the world. Based on detailed observation and sample analysis results of a total 5000 m of core from over 70 wells in the above-mentioned two basins, especially sulfur isotopic analysis of gypsum, brimstone, pyrite and natural gas, also with integrated study of the geochemical characteristics of hydrocarbons, it is thought that the natural gas with high H2S contents resulted from thermochemical sulfate reduction (TSR) reactions. Among them, the natural gas in the Feixianguan Formation resulted from TSR reactions participated by hydrocarbon gas, while that in the Zhaolanzhuang of the Jinxian Sag being the product of TSR participated by crude oil. During the consumption process of hydrocarbons due to TSR, the heavy hydrocarbons were apt to react with sulfate, which accordingly resulted in the dry coefficient of natural gas increasing and the carbon isotopes becoming heavier. | ZHU Guangyou ZHANG Shuichang LIANG Yingbo DAI Jinxing LI Jian | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 36 |
| 13 | Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity显示文摘瞄准:在导致 PC-2 房间 apoptosis 并且提高它的放射敏感度在胰腺的癌症房间线 PC-2 和 siRNA 的角色在 survivin 的表示上调查小介入 RNA (siRNA ) 的禁止的效果。方法:对 survivin 的 siRNA 原生质标志表示向量被构造并且 transfected 进有 Lipofectamine 2000 的 PC-2 房间。下面 survivin 表示的规定被半量的 RT-PCR 和免疫检测组织化学的 SP 方法和在导致 PC-2 房间 apoptosis 并且提高它的放射敏感度的 siRNA 的角色被流动血细胞计数检测。结果:顺序特定的 siRNA 高效地并且明确地下面调整在 mRNA 和蛋白质的 survivin 的表示铺平。表示抑制比率在半量的 RT-PCR 检测的 mRNA 水平是 81.25% , 74.24% 由免疫在蛋白质水平检测了组织化学的方法。在 transfection 以后的 48 个小时, apoptosis 被 siRNA 在 7.03% 房间导致,在 14.58% ,由 siRNA 的房间与放射结合了。结论:对 survivin 的 siRNA 原生质标志表示向量能高效地并且明确地在 PC-2 房间禁止 survivin 的表示。禁止 survivin 的表示能导致 PC-2 房间的 apoptosis 并且显著地提高它的放射敏感度。对 survivin 的 RNAi 具有在胰腺的癌症的基因治疗的潜在的价值。 | Hai-Tao Guan Xing-Huan Xue Zhi-Jun Dai Xi-Jing Wang Ang Li Zhao-Yin Qin | 2006 | World Journal of Gastroenterology2006，12，18： | 40 |
| 14 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 15 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 16 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 17 | Treatment of malignant biliary obstruction by combined percutaneous transhepatic biliary drainage with local tumor treatment显示文摘瞄准:为了评估本地肿瘤的用途,治疗为恶意的妨碍的胆汁的疾病把胆汁的排水(PTBD ) 与经皮的 transhepatic 相结合。方法:有恶意的胆汁的阻塞的 233 个病人的一个总数被金属性的 stents 或塑料试管的放置与 PTBD 在我们的医院里对待。在 PTBD 以后, 49 个病人接受了 brachytherapy 或额外放射的治疗或动脉的注入化疗。病人被跟随在上面与临床、 X 光线照相术的评估。幸存和斯滕特氏印模膏明显率被 Kaplan-Meier 幸存分析计算。结果: 22 个病人经历了化疗(肝的癌的 11 个盒子,胰腺的癌的 7 个盒子,变形淋巴结病的 4 个盒子),并且 14 个病人收到了放射疗法( cholangiocarcinoma 的 10 个盒子,胰腺的癌的 4 个盒子),并且 13 个病人接受了 brachytherapy ( cholangiocarcinoma 的 7 个盒子,胰腺的癌的 3 个盒子,变形淋巴结病的 4 个盒子)。在 1, 3, 6,和 12 个月的本地肿瘤治疗组的幸存率分别地是 97.96% , 95.92% , 89.80% ,和 32.59% ,比的长非治疗组。在 1, 3, 6,和 12 个月的明显率分别地是 97.96% , 93.86% , 80.93% ,和 56.52% 。明显率的差别不在治疗组之间是重要的,非,治疗组织。结论:我们的结果建议那本地肿瘤治疗能与恶意的胆汁的阻塞延长病人的生存时间,并且可以改进斯滕特氏印模膏明显。 | Xiao-Jun Qian Ren-You Zhai Ding-Ke Dai Ping Yu Li Gao | 2006 | World Journal of Gastroenterology2006，12，2： | 31 |
| 18 | Discovery of the superlarge gallium ore deposit in Jungar,Inner Mongolia,North China显示文摘Mineralogy and geochemistry of No.6 Coal from the Heidaigou Mine of the Jungar Coalfield of North China were studied using instrumental neu- tron activation analysis,inductively coupled-plasma mass spectroscopy,X-ray fluorescence spectrometry,and scanning electron microscope equipped with an energy-dispersive X-ray spectrometer. The results show that gallium concentration is as high as 44.8 μg·g?1 in the whole coal-channel sample,and varies from 30.1 μg·g?1 to 76.0 μg·g?1 (mean 51.9 μg·g?1) in the main minable benches of No.6 Coal. Such high concentration of Ga in the coal is far higher than the industrial grade (30 μg·g?1). The thickness of the main minable benches accounts for 81.9% of the whole coal bed. The laboratory high-temperature ashes (550℃) of the main minable coal benches also contain a high concentration of Ga,varying from 62.2 μg·g?1 to 178 μg·g?1,with an average of 89.2 μg·g?1. The boehmite significantly enriched in No.6 Coal is the main carrier of the high Ga in the coal. Average concentration of Ga in boehmite is 0.09%. The av- erage content of boehmite is 6.1% in the whole coal and 7.5% in the main minable benches. Boehmite is derived from the bauxite in the weathered crust of the underlying Benxi Formation in the north of the basin during the peat accumulation. The colloidal idrargillite had been shortly transported from the weathered crust to the peat mire,and owing to the compaction of the overlying strata during the peat accumulation and early diagenesis,the idrargillite colloid had begun to be dehydrated,leading to boehmite formation. A pre- liminary estimation showed that the ensured and prospected reserves of Ga in No.6 Coal are up to 6.3 ×104t and 8.57×105t,indicating a superlarge galliumore deposit. The particular paleogeography of the Jungar Coalfield and the peculiar carrier of Ga in coal suggest that this Ga ore deposit is unique in the world. Rare earth elements are also enriched in coal and laboratory ashes. The weighted average concentra- tion of the total rare earth elements is 255 μg·g?1 and 830.36 μg·g?1 in the main minable benches and their laboratory ashes,respectively. Because Al is the main composition of boehmite,aluminum and rare earth elements in No.6 Coal are also the available and valuable resources. | DAI Shifeng REN Deyi LI Shengsheng | 2006 | Chinese Science Bulletin2006，51，18： | 32 |
| 19 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 20 | Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma显示文摘Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is such a preferred candidate,because artesunate is clinically well-tolerated and more importantly both drugs can induce ferroptosis through different mechanisms.In this study we investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of HCC and elucidated the involved molecular mechanisms.We showed that artesunate greatly enhanced the anticancer effects of low dose of sorafenib against Huh7,SNU-449,and SNU-182 HCC cell lines in vitro and against Huh7 cell xenograft model in Balb/c nude mice.The combination index method confirmed that the combined effect of sorafenib and artesunate was synergistic.Compared with the treatment with artesunate or sorafenib alone,combined treatment induced significantly exacerbated lipid peroxidation and ferroptosis,which was blocked by N-acetyl cysteine and ferroptosis inhibitors liproxstatin-1 and deferoxamine mesylate,but not by inhibitors of other types of cell death(z-VAD,necrostatin-1 and belnacasan).In Huh7 cells,we demonstrated that the combined treatment induced oxidative stress and lysosome-mediated ferritinophagy,two essential aspects of ferroptosis.Sorafenib at low dose mainly caused oxidative stress through mitochondrial impairments and SLC7A11-invovled glutathione depletion.Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation,ferritin degradation,lipid peroxidation,and consequent ferroptosis.Taken together,artesunate could be repurposed to sensitize sorafenib in HCC treatment.The combined treatment can be easily translated into clinical applications. | Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 31 |
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