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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Myocardial Cell Death in Human Diabetes显示文摘 | Andrea Frustaci Jan Kajstura Cristina Chimenti Igor Jakoniuk Annarosa Leri Attilio Maseri Bernardo Nadal-Ginard Piero Anversa | 2000 | Circulation Research: Journal of the American Heart Association2000，，12： | 4 |
| 3 | Tow-year remission and subsequent relapse in children with newly diagnosed epilepsy显示文摘 | Berg AT Shinnar S Lery SR | 2002 | Epilepsy2002，42，12： | 1 |
| 4 | Cardiac stem cel s and mechanisms of myocardial regeneration显示文摘 | Leri A Kajstura J Anversa P | | 0，，04： | 1 |
| 5 | Cardiac stem cells and mechanisms of myocardial regeneration显示文摘 | Leri A Kajstura J Anversa P | 2005 | Physiological Reviews2005，85，4： | 1 |
| 6 | Myocyte growth in the failing heart显示文摘 | KAJSTURA J LERI A CASTALDO C | 2004 | Surg Clin North Am2004，84，1： | 1 |
| 7 | Myocyte proliferation in end stage cardiac failure in humans显示文摘 | Kajstura J Leri A Beltrami AP | 1998 | PNAS1998，95，15： | 1 |
| 8 | Long-term outcomes after meningioma radiosurgery: The physicin and patients perspective显示文摘 | KONDZIOLKA D LERY E NIRANIAN A | 1999 | J neu rosurg1999，91，1： | 1 |
| 9 | Life and death of cardiac stem cells:a paradigm shift in cardiac biology显示文摘 | Anversa P Kajstura J Leri A | 2006 | Circulation2006，113，11： | 1 |
| 10 | Life and death of cardiac stem cells:a paradigm shift in cardiac biology显示文摘 | Anversa P Kajstura J Leri A | 2006 | Circulation2006，113，11： | 1 |
| 11 | Myocyte proliferation in end-stage cardiac failure in humans显示文摘 | Kajstura J Leri A Finato N | 1998 | Proc Natl Acad Sci USA1998，95，15： | 1 |
| 12 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 13 | Canine ventficular myocytes possess a rennin-angiotension system that is upregulated with heart failure显示文摘 | Barlucehi L Leri A Dostal DE | 2001 | Cir Res2001，88，3： | 1 |
| 14 | Myocyte proliferation in end-stage cardiac failure in humans显示文摘 | Kajstura J Leri A Finato N | 1998 | Proc-Natl-Acad-Sci USA1998，95，15： | 1 |
| 15 | The part-through surface crack in an elastic plate 显示文摘 | Rice J R Lery N | 1972 | Journal of Applied Mechanics1972，39，： | 1 |
| 16 | Life and death of cardiac stem cells: a paradigm shift in cardiac biology 显示文摘 | Anversa P Kajstura J Leri A | 2006 | Circulation2006，113，11： | 1 |
| 17 | Cardiac stem cells and mechanisms of myocardial regeneration 显示文摘 | Leri A Kajstura J Anversa P | 2005 | Physiol Rev2005，85，4： | 1 |
| 18 | A 5 - flap procedure for axilary Webs Leaving the a peantact 显示文摘 | Hirshowitz B Karev A Lery Y | 1977 | Br J Plast Surg1977，30，： | 1 |
| 19 | The essential function of the right heart ventricle显示文摘 | Furey SA Zieske HA Lery MN | 1984 | An Heart J1984，107，5： | 1 |
| 20 | Review cast magnesium alloys for elevated temperature applications显示文摘 | Luo A Pekgtüleryüz O | 1994 | Journal of Materials Science1994，，29： | 1 |
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