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| 1 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 2 | 已确诊冠心病患者的治疗及预后:关于冠状动脉血运重建的欧洲心脏调查 | Lenzen M. J. Boersma E. Bertrand M. E. W. Wijns 刘少伟 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，12： | 8 |
| 3 | The mechanisms of alloxan- and streptozotocin-induced diabetes显示文摘 | S. Lenzen | 2008 | Diabetologia2008，，2： | 5 |
| 4 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 5 | The mechanisms of alloxan- and streptozotocin-induced diabetes显示文摘 | S. Lenzen | 2008 | Diabetologia2008，，2： | 2 |
| 6 | Examining the global environmental impact of regional consumption activities — Part 2: Review of input–output models for the assessment of environmental impacts embodied in trade显示文摘 | Thomas Wiedmann Manfred Lenzen Karen Turner John Barrett | 2006 | Ecological Economics2006，，1： | 2 |
| 7 | A research agenda for improving national Ecological Footprint accounts显示文摘 | Justin Kitzes Alessandro Galli Marco Bagliani John Barrett Gorm Dige Sharon Ede Karlheinz Erb Stefan Giljum Helmut Haberl Chris Hails Laurent Jolia-Ferrier Sally Jungwirth Manfred Lenzen Kevin Lewis Jonathan Loh Nadia Marchettini Hans Messinger Krista Mil | 2008 | Ecological Economics2008，，7： | 2 |
| 8 | Primary energy and greenhouse gases embodied in Australian final consumption: an input–output analysis显示文摘 | Manfred Lenzen | 1998 | Energy Policy1998，，6： | 2 |
| 9 | Primary Energy and Creenhouse Gases Embodied in Australian Final Consumption:an Inpur-output Analysis显示文摘 | Lenzen M | 1998 | Energy Policy1998，26，6： | 1 |
| 10 | Importance of mitochondrial superoxide dismutase expression in insulinproducing cells for the toxicity of reactive oxygen species and proinflammatory cytokines显示文摘 | Lortz S Gurqul-Convev E Lenzen | 2005 | Diabetologia2005，48，8： | 1 |
| 11 | A material history of Australia显示文摘 | Wood R Lenzen M Foran B | 2009 | Journal of Industrial Ecology2009，15，6： | 1 |
| 12 | On the Conversion Between Local and Global Hectares in Ecological Footprint Analysis 显示文摘 | WlEDMANN T LENZEN M | 2007 | Ecological Economics2007，60，4： | 1 |
| 13 | Primary energy and greenhouse gases embodied in Australian final consumption:an input-output analysis显示文摘 | Manfred Lenzen | 1998 | Energy policy1998，26，6： | 1 |
| 14 | Peroxisome-generated hydro- gen peroxide as important mediator of lipotoxicity in insulin- producing cells显示文摘 | Eisner M Gehnnann W Lenzen S | 2011 | Diabetes2011，60，1： | 1 |
| 15 | Using input-output analysis to measure the environmental pressure of consumption at different spatial levels 显示文摘 | Jesper M Wier M Lenzen M | 2005 | Journal of Industrial Ecology2005，9，12： | 1 |
| 16 | Diabetes known or newly de tected, but not impaired glucose regulation, has a negative influ- ence on 1 year outcome in patients with coronary artery disease: a report from the Euro Heart Survey on diabetes and the heart显示文摘 | Lenzen M Ryden L Ohrvik J | 2006 | Eur Heart J2006，27，24： | 1 |
| 17 | Asymmetric dimethylarginine is an independent risk factor for coronary heart disease:Results from the multicenter Coronary Artery Risk Determination investigating the influnce of ADMA Concentration (CARDIAC) study显示文摘 | Friedrich Schulzc Henrike Lenzen Christoph Hanefeld | 2006 | American Heart Journal2006，152，3： | 1 |
| 18 | Water accounting in australia 显示文摘 | VARDON M LENZEN M PEEVOR S | 2007 | Ecological Economics2007，61，4： | 1 |
| 19 | Global objective tropopause analysis显示文摘 | Hoerling M P Schaack T K Lenzen A J | 1991 | Monthly Weather Review1991，119，： | 1 |
| 20 | Differences between patients with a preserved and a depressed left ventricular function: a report from the Euro Heart Failure Survey 显示文摘 | Lenzen MJ Scholte op Reimer WJ Boersma E | 2004 | Eur Heart J2004，25，14： | 1 |
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