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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | 新一代渴望导管: 在肺的栓塞的处理的可行性显示文摘 AIM: To report our preliminary experience with a new generation aspiration catheter in the treatment of symptomatic pulmonary embolism(PE). METHODS: A retrospective database search for pulmonary artery embolectomy since introduction of the Pronto.035' and XL extraction catheter(Vascular Solutions, Minneapolis, MN) at our institution in 10/2009 was performed. Ten consecutive patients were identified in which the Pronto.035' or XL catheter was used between 01/2010 and 03/2013. All patients were referred for catheter based embolectomy due to contraindications to systemic lysis, or for being in such a critical clinical condition that immediate percutaneous treatment deemed warranted. The computed tomography(CT) right to left heart ratio as predictor for the severity of the PE was retrospectively evaluated on standard axial views. The difference between pre- and post-procedure pulmonary pressure measures was taken to assess the procedural effect.RESULTS: Extensive PE was confirmed angiographically in all patients. Measured right- to left ventricle(RV/LV) ratios were elevated beyond one in seven of the eight available CTs. Acute procedural success defined as clinical removal of visible thrombus and improvement in mean pulmonary artery pressure was seen in all recorded patients(n = 8), the mean pulmonary pressures declined from a median(range) of 35.5(19-46) to 23(10-37, P = 0.008) mmHg. Neither death nor other complications occurred intra- or immediately periprocedural, yet short term mortality within 30 d was found in 6 out of 9 patients, one patient was lost in follow up. The cause of death within 30 d in the 6 patients was identified as: Circulatory failure in direct connection with the PE(n = 2), stroke, sepsis, or succumbing to malignancy in a hospice setting(n = 2). CONCLUSION: Success in thrombus removal with improved pulmonary hypertension and systemic hypotension suggests this aspiration technique to be effective. Aspiration catheters should be part of further trials. | Wolf E Heberlein Mollie E Meek Omar Saleh James C Meek Shelly Y Lensing William C Culp | 2013 | World Journal of Radiology2013，5，11： | 2 |
| 3 | High rate sulfate reduction in a submerged anaerobic membrane bioreactor (SAMBaR) at high salinity显示文摘 | Marcus V.G. Vallero Gatze Lettinga Piet N.L. Lens | 2005 | Journal of Membrane Science2005，，1： | 2 |
| 4 | Interferon-Free Regimens in the Liver-Transplant Setting显示文摘 | Sabela Lens Martina Gambato María-Carlota Londo?o Xavier Forns | 2014 | Semin Liver Dis2014，，01： | 2 |
| 5 | EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer显示文摘 | Raquel Dávila Fajardo Selma J. Lekkerkerker Astrid van der Horst Eelco Lens Jacques J. Bergman Paul Fockens Arjan Bel Jeanin E. van Hooft | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 6 | Deep-vein thrombosis显示文摘 | Prandoni P Prins MH | 1999 | Lancet1999，353，： | 1 |
| 7 | Safety of low-molecularweight heparin in pregnancy:a systematic review显示文摘 | Sanson BJ Lensing AW Prins MH | 1999 | ThrombHaemost1999，81，5： | 1 |
| 8 | Below-knee elastic compression stockings to prevent the post-thrombotic syndrome:a randomized,controlled trial显示文摘 | Prandoni P Lensing AW Prins MH | 2004 | Ann Intern Med2004，141，4： | 1 |
| 9 | Anti-CTLA4 monoclonal antibody Ipilimumab in the treatment of metastatic melanoma:recent findings显示文摘 | Lens M Ferrucci PF Testori A | | 0，，2： | 1 |
| 10 | Separation of Ownership and Contro显示文摘 | Fama Eugene and Lense Michael | 1983 | Journal o( Law and Economics1983，，26： | 1 |
| 11 | Sulfate reduction during the acidification of sucrose at pH 5 under thermophilic (55<ce:hsp sp='0.25'/>°C) conditions. II: Effect of sulfide and COD/ SO 4 2 - ratio显示文摘 | S.I.C. Lopes M.I. Capela P.N.L. Lens | 2010 | Bioresource Technology2010，，12： | 1 |
| 12 | Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism显示文摘 | Prandoni P Lensing AW Prins MH | 2002 | Ann Intern Med2002，137，12： | 1 |
| 13 | Contrast venography,the gold standard for the diagnosis of deep vein thrombosis:improvement in observer agreement 显示文摘 | Lensing AW Buller HR Prandoni P | 1992 | Thromb Haemost1992，67，： | 1 |
| 14 | Comparison of subcutaneous low molecular weight heparin with intravenous standard heparin in proximal deep-vein thrombosis 显示文摘 | Prandoni P Lensing AW Bailer HR | 1992 | Lancet1992，339，8791： | 1 |
| 15 | Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromhoembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies 显示文摘 | Prins MH Lensing AW Bauersachs R | 2013 | Thromb J2013，11，1： | 1 |
| 16 | Effect of COD/SO 4 2? ratio and sulfide on thermophilic (55<ce:hsp sp='0.16'/>°C) sulfate reduction during the acidification of sucrose at pH 6显示文摘 | S.I.C. Lopes X. Wang M.I. Capela P.N.L. Lens | 2007 | Water Research2007，，11： | 1 |
| 17 | Contrast venography,the gold standard for the diagnosis deep-veinthrombosis:improvement in observer agreement显示文摘 | Lensing AW Buller HR Prandoni P | 1992 | Thromb Haemost1992，67，1： | 1 |
| 18 | Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy显示文摘 | Sefia AC Lensing S Rompalo A | 2012 | J Infect Dis2012，206，3： | 1 |
| 19 | Body surface area adapted iopromide 300 mg/ml versus 370 mg/mL contrast medium injection protocol:influence on quantitative and clinical assessment in combined PET/CT 显示文摘 | Verburg FA Apitzsch J Lensing C | 2013 | Eur J Radio12013，82，12： | 1 |
| 20 | Near-shore distribution of heavy metals in the Albanian part of Lake Ohrid显示文摘 | Egina Malaj Diederik P. L. Rousseau Gijs Du Laing Piet N. L. Lens | 2012 | Environmental Monitoring and Assessment2012，，4： | 1 |
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