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132篇 您的检索式：作者名="Lens L"

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	题名	作者	年代	出处	被引量
1	Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.	Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns	2015	World Journal of Gastroenterology2015，21，17：	4
2	Cluster structure of anaerobic aggregates of an expanded granular sludge bed reactor显示文摘	Gonzalez-Gil G Lens P N L Aelst A	2001	Applied and Environmental Microbiology2001，67，：	1
3	The contact characteristics of rough surfaces in line contact during running-in process显示文摘	HORNG J H LEN M L LEE J S	2002	Wear2002，253，：	1
4	Effect of staging on volatile fatty acid degradation in a sulfidogenic granular sludge reactor显示文摘	Lens P N L Bosch M C V D Pol L W H	1998	Water Research1998，32，4：	1
5	Validation of FLT uptake as a measure of thymidine kinase 21 activity in A549 carcinomacells显示文摘	Rasey J S GR Ierson J R W lens L W	2002	J Nucl Med2002，43，9：	1
6	Human gliosarcoma-associated ganglioside compo- sition is complex and distinctive as evidenced by high perform- ance mass spectrometric determination and structural charac- terization显示文摘	VukelieZ Kalanj-Bognar S Froesch M Bindila L Radie B Al- len M	2007	Glyeobiology2007，17，：	1
7	Seabed morphology and hydrocarbon seep age in the Gulf of Cadiz mud volcano area:Acoustic imagery,multibeam and ultra-high resolution seismic data显示文摘	Somoza L Diaz del Rio V Len R		0，，14：	1
8	Effect of feedcomposition and upflow velocity on aggregate characteristics in anaerobic upflow reactors 显示文摘	O'Flaherty V Lens P N L Beer D D	1997	Applied Microbiology & Biotechnology1997，47，2：	1
9	Effect of staging on volatile fatty acid degradation in a sulfidogenic granular sludge reactor 显示文摘	Lens P N L Van Den Bosch M C Hulshoff Pol L W	1998	Water Researeh1998，32，4：	1
10	Effect of NaCl on thermophilic (55℃) methane degradation in sulfate reducing granular sludge reactors显示文摘	Vallero M V G Hulshoff Pol L W Lettinga G Lens P N L	2003	Water Research2003，，37：	1
11	Serrated polyps of the colon: how reproducible is their classification?显示文摘	Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B	2012	Virchows Archiv2012，，5：	1
12	Removal of H2S and volatile organic sulfur compounds by silicone membrane extraction 显示文摘	Manconi I Lens P N L	2009	Journal of Chemical Technology and Biotechnology2009，84，1：	1
13	Understanding the impact of intrinsic versus extrinsic goal framing on exercise performance:the conflicting role of task and ego involvement显示文摘	VANSTEENKISTE M MATOS L LENS W	2007	Psychology of Sport and Exercise2007，，8：	1
14	Biotechnological treatment of sulfate-rich wastewaters 显示文摘	Lens P N L Visser A Janssen A J H	1998	Critical Reviews in Environmental Science and Technology1998，28，1：	1
15	The mucosal immune response to laryngopharyngeal reflux 显示文摘	Rees LEN Pazmany L Gutowska-Owsiak D	2008	Am J Respir Crit Care Med2008，177，：	1
16	Nickel and cobalt sorption on anaerobic granular sludges:kinetic and equilibrium studies显示文摘	Hullebusch Eric D V Zandvoort M H Lens P N L	2004	Journal of Chemical Technology and Biotechnology2004，79，：	1
17	Constitutive models for cohesive zones in mixed-mode fracture of plain concrete显示文摘	Lens L N Bittencourt E Avila V M R	2009	Engineering Fracture Mechanics2009，76，：	1
18	Measurements of CO, COz, OH and H20 in room-temperature and combustion gases by use of a Broadly current-tuned multisection InGaAsP diode la- ser显示文摘	PSCHULTE B L SONNENENFROH D M AL- LEN M G	1999	Applied Optics1999，38，9：	1
19	The essential toxin : the changingperception of selenium in environmental sciences 显示文摘	Lenz M Lens P N L	2009	Science ofthe Total Environment2009，407，12：	1
20	The essential toxin:The changing perception of selenium in environmental sciences显示文摘	Lenz M Lens P N L		0，，12：	1

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