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| 1 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 2 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 3 | Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department显示文摘BACKGROUND: Harmless acute pancreatitis score(HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width(RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department(ED).METHODS: Patients diagnosed with acute pancreatitis(K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography(CT) in the ED were not included in the study.RESULTS: Ultimately, 322 patients were included in the study. The median age of the patients was 53.1(IQR=36–64). Of the patients, 68.1%(n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3%(n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification(OR: 15; 95% CI: 3.5 to 64.4).CONCLUSIONS: HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classifi cation. | Bedia Gülen Ertan Sonmez Serpil Yaylaci Mustafa Serinken Cenker Eken Ali Dur Figen Tunali Turkdogan ?zgür S?güt | 2015 | World Journal of Emergency Medicine2015，6，1： | 13 |
| 4 | Sonography of the small intestine显示文摘In the last two decades, there has been substantial development in the diagnostic possibilities for examining the small intestine. Compared with computerized tomography, magnetic resonance imaging, capsule endoscopy and double-balloon endoscopy, ultrasonography has the advantage of being cheap, portable, flexible and user-and patient-friendly, while at the same time providing the clinician with image data of high temporal and spatial resolution. The method has limitations with penetration in obesity and with intestinal air impairing image quality. The flexibility ultrasonography offers the examiner also implies that a systematic approach during scanning is needed. This paper reviews the basic scanning techniques and new modalities such as contrast-enhanced ultrasound, elastography, strain rate imaging, hydrosonography, allergosonography, endoscopic sonography and nutritional imaging, and the literature on disease-specific findings in the small intestine. Some of these methods have shown clinical benefit, while others are under research and development to establish their role in the diagnostic repertoire. However, along with improved overall image quality of new ultrasound scanners, these methodshave enabled more anatomical and physiological changes in the small intestine to be observed. Accordingly, ultrasound of the small intestine is an attractive clinical tool to study patients with a range of diseases. | Kim Nylund Svein Фdegaard Trygve Hausken Geir Folvik Gülen Arslan Lied Ivan Viola Helwig Hauser Odd-Helge Gilja | 2009 | World Journal of Gastroenterology2009，15，11： | 9 |
| 5 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic scores.METHODS:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy controls.The correlation between the clinical and histopathological features of NASH patients and RDW values was evaluated.Liver fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced fibrosis.RDW values were compared between NASH,simple steatosis and healthy controls.Univariate and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by NASH.RESULTS:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores. | Mustafa Cengiz Burcu Aslan Candir Güldal Yilmaz Gülen Akyol Seren Ozenirler | 2013 | World Journal of Gastroenterology2013，19，42： | 8 |
| 6 | Cluster structure of anaerobic aggregates of an expanded granular sludge bed reactor显示文摘 | Gonzalez-Gil G Lens P van Aelst AC | 2001 | Appl Environ Microbiol2001，67，8： | 1 |
| 7 | An efficient integration of algorithms to evaluate the quality of free form surfaces显示文摘 | Lennings A F Peters J G Vergeest J S M | 1995 | Computer & Graphics1995，19，6： | 1 |
| 8 | Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres显示文摘 | Lens SM Rodriguez JA Vader G | 2006 | MolBiol Cell2006，17，4： | 1 |
| 9 | Cluster structure of anaerobic aggregates of an expanded granular sludge bed reactor显示文摘 | Gonzalez-Gil G Lens P N L Aelst A | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 10 | A Knowledge Based SWOT -- analysis System as an Instrument forStrategic Planning in Small and Medium Sized Enter2p rises 显示文摘 | HOUBEN G LEN IE K VANHOOF K | 1999 | Decision Support System1999，26，2： | 1 |
| 11 | Perform- ance of a sulfide - oxidizing expanded - bed reactor sup- plied with dissolved oxygen显示文摘 | Janssen A J H Ma S N Lens P Lettinga G | 1997 | Biotechnol Bioeng1997，53，01： | 1 |
| 12 | Long-term efficacy andsafety of lamivudine,entecavir,and tenofovir for treatment of hepatitis B virus-related cirrhosis显示文摘 | KklüS Tuna Y Gülen MT | 2013 | Clin Gastroenterol Hepatol2013，11，1： | 1 |
| 13 | User-Friendly Mathematical Model for the Design of Sulfate Reducing H2 / C02 Fed Bioreac- tors 显示文摘 | Esposito G Lens P Pimzzi F | 2009 | Environment Engineering2009，135，3： | 1 |
| 14 | Effect of NaCl on thermophilic (55℃) methane degradation in sulfate reducing granular sludge reactors显示文摘 | Vallero M V G Hulshoff Pol L W Lettinga G Lens P N L | 2003 | Water Research2003，，37： | 1 |
| 15 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 16 | The case for Survivin as mitotic regulator显示文摘 | Vader G Medema RH | 2006 | Curr Opin Cell Biol2006，18，6： | 1 |
| 17 | Measurements of CO, COz, OH and H20 in room-temperature and combustion gases by use of a Broadly current-tuned multisection InGaAsP diode la- ser显示文摘 | PSCHULTE B L SONNENENFROH D M AL- LEN M G | 1999 | Applied Optics1999，38，9： | 1 |
| 18 | Broadband Beam- forming of Focal Plane Array (PFA) Signals Using Real-Time Spatio-Temporal 3D FIR Frustum Digital Filters 显示文摘 | THUSHARA K G LEN B PAN A | 2011 | IEEE Transactions on Antennas and Prop- agation2011，59，6： | 1 |
| 19 | The case for survivin as mitotic regulator显示文摘 | Lens SM Vader G Medema RH | 2006 | Curr Opin Cell Bio12006，18，： | 1 |
| 20 | Fractals geometry model for wear prediction 显示文摘 | Zhou G Y Len M C Blackmore D | 1993 | Wear1993，170，： | 1 |
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