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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Pneumoniae of Swines Cost and Value of Control显示文摘 | Leman A D T Stein B Straw H D Hilley | 1982 | Mod Vet Pract1982，63，： | 1 |
| 3 | Spy: A Windows CE API interceptor 显示文摘 | LEMAN D | 2003 | Doctor Dobbs Journal2003，28，10： | 1 |
| 4 | Signal-averaged P-wave analysis of normal controls and patients with paroxysmal atrial fibrillation: a study in gender differences, age dependence,and reproducibility显示文摘 | Dhala A Underwood D Leman R | 2002 | Clin Cardiol2002，25，： | 1 |
| 5 | Toward communicating expressiveness and affect in multimodal interactive systems for performing arts and cultural applications显示文摘 | Camurri A Poli G D Leman M | 2005 | IEEE Multimedi- a2005，12，1： | 1 |
| 6 | The properties of some magnesium-lithium alloys containing aluminum and zinc 显示文摘 | BUSK R S LEMAN D L CASEY J J | 1950 | Trails AIME1950，188，： | 1 |
| 7 | 显示文摘 | Bush R S Leman D L Casey J J | 1950 | Trans AIME1950，188，： | 1 |
| 8 | Simultaneous NOx and SOx reduction from oxyfuel exhaust gases using acidic solutions containing hydro- gen peroxide显示文摘 | LEMANS I THOMAS D | 2013 | Energy Procedia2013，37，： | 1 |
| 9 | Advanced photonic crystal architectures from colloidal self- assembly techniques 显示文摘 | PRASAD T RENGARAJAN R MI33'LEMAN D M | 2005 | Optical Materials2005，27，7： | 1 |
| 10 | Antibody responses of guiued- pigs, rabbits and pigs to inactivated porcine parvovirus vaccines 显示文摘 | Joo H S Molitor T W Leman A D | 1984 | Vet Microbiol1984，9，1： | 1 |
| 11 | Antibody responses of guinea - pigs,rabbits and pigs to inactivated porcine parvovirus vaccine显示文摘 | JOO H S MOUTOR T W LEMAN A D | 1984 | Vet Microbiol1984，9，1： | 1 |
| 12 | Current concepts review the management of open fractures 显示文摘 | Gust ilo RB M erkow RL Temp leman D | 1990 | BoneJo int Surg1990，72，1： | 1 |
| 13 | Factors that influence litter size in pigs显示文摘 | Clark L K Leman A D Morris R | 1986 | Pig News and Information1986，73，： | 1 |
| 14 | Seasonal influence on the fertility of sows and gilts显示文摘 | Hurtgen J P Leman A D | 1980 | J Am Vet Ned Assoc1980，177，7： | 1 |
| 15 | Boar management显示文摘 | Leman A D Rodeffer H E | 1976 | The Veterinary Record1976，，23： | 1 |
| 16 | Factors that influence litter size in pigs: Part 1 显示文摘 | Clark L K Leman A D | 1986 | Pig News and Information1986，7，3： | 1 |
| 17 | Factors that influence litter size in pigs: Part 2 显示文摘 | Clark L K Leman A D | 1986 | Pig News and Information1986，7，3： | 1 |
| 18 | Droplet-based mi- erofluidics at the femtolitre scale显示文摘 | Leman M Abouakil F Griffiths A D | 2015 | Lab Chip2015，15，3： | 1 |
| 19 | The properties of some magnesium-lithium alloys containing aluminum and zinc 显示文摘 | Busk R S Leman D L Casey J J | 1950 | Journal of Metals1950，，7： | 1 |
| 20 | Pneumoniae of swine: it' s cost and value of control显示文摘 | LEMAN A D STEIN B S HILLEY H D | 1982 | Mod Vet Pract1982，63，： | 1 |
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