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| 1 | New Insights into the Late Triassic Nadigangri Formation of Northern Qiangtang, Tibet, China: Constraints from U-Pb Ages and Hf Isotopes of Detrital and Magmatic Zircons显示文摘We report here U-Pb age and in situ Hf isotopic results for detrital and magmatic zircons from one conglomerate and four tuffite samples from the Late Triassic Nadigangri Formation across the North Qiangtang depression, Tibet. Coupled with previously published data in the region, this paper proposes new insights into the geochronological framework for the Nadigangri Formation. The deposition ages of tuffite from top to bottom in the Woruo Mountain, Quem Co and Dongqu River, are 203 Ma, 226 Ma, 221.5 Ma and 221.1 Ma, respectively. The detrital zircons yield a younger cluster of ages of 201.5–225 Ma from the conglomerate of the Quem Co Formation. The Late Triassic Nadigangri Formation defines a temporal range approximately between 201 and 225 Ma(Norian-Rhaetian), including three predominant groups of 220–225 Ma, 210–217 Ma and 201–205 Ma, which correspond with the three main rifting episodes of initial rifting, further rifting and final rifting. Positive εHf(t) value and low model ages in younger detrital zircons suggests a juvenile character. However, the Hf isotopes of magmatic zircons display the presence of reworked ancient crust with 1.1–1.8 Ga. These results provide strong constraints not only on the temporal range of the Late Triassic Nadigangri Formation, but also on the onset of the Qiangtang Mesozoic rift basin. | LI Xueren WANG Jian CHENG Leli FU Xiugen WANG Yuke | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 5 |
| 2 | Signaling pathways and therapeutic interventions in gastric cancer显示文摘Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related death.Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence rates.With the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and prognosis.Modern molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic responsiveness.These biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC patients.Nevertheless,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well understood.Here,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent discoveries.Current therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are discussed.These advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments. | Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 4 |
| 3 | Pro-apoptotic and anti-proliferative effects of Physalis angulata leaf extract on retinoblastoma cells显示文摘AIM: To investigate the effect of Physalis angulata leaf extract on apoptotic and proliferation of retinoblastoma cells. Despite several previous studies evidencing the anticancer potential of Physalis angulata;however, certain study that proves its benefits in retinoblastoma cancer cells has been limited.METHODS: This study utilizes an in-vitro experimental study by applying Y79 human retinoblastoma cell line culture obtained from the American Type Culture Collection(ATCC;10801 University Boulevard Manassas, VA 20110, USA). The cell was divided into 4 groups. Group I was the control group without the administration of Physalis angulata leaf extract. Whereas, group II, II and IV are engaged with 25, 50, and 100 μg/mL of Physalis angulata leaf extract respectively. After a 24 h incubation, an examination with microtetrazolium(MTT) cell proliferation assay and Annexin V apoptosis detection was conducted. Statistical analysis was performed with the Tukey test.RESULTS: Physalis angulata leaf extract improved apoptosis and significantly reduced the number of living cells in retinoblastoma cells, along with the increase in the given dose. Based on the Tukey test, a significant difference was found in the treatment group at 50 μg/mL(P=0.025) and 100 μg/mL(P=0.001) in the measurement of apoptosis. Proliferation measurements also indicated a significant decrease in the number of living cells in the 50μg/m L treatment group(P=0.004), and in the 100 μg/mL treatment group(P=0.000). Meanwhile, a dose of 25 μg/mL indicated insignificant difference in the two measurements. Improved apoptosis and decreased number of living cells occured at a dose of 100 μg/mL. Decreased number of living cells(in the measurement of proliferation) was due to the inhibited proliferation or improved apoptosis.CONCLUSION: Physalis angulata leaf extract improve apoptosis in retinoblastoma cell culture, requiring further research to inhibit proliferation. | Marsha Dechastra Chairissy Lely Retno Wulandari Hidayat Sujuti | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 3 |
| 4 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 5 | Immersedmembrane filtration for the production of drinking water:combination with PAC for NOM and SOCs removal显示文摘 | Thomas Lebeau Claire Lelie vre | 1998 | Desalination1998，117，13： | 1 |
| 6 | Endophytic bacteria from seeds of Nicotinana tabacum can reduce cadmium phytotoxicity显示文摘 | MASTRETTA C TAGHAVI S van der Lelie D | 2009 | International Journal of Phytoremodiation2009，11，3： | 1 |
| 7 | Diagnosis of infective endocarditis : comparison of the Light Cycler Septi Fast real-time PCR with blood culture 显示文摘 | Mencacci A Leli C Montagna P | 2012 | J Med Microbiol2012，61，6： | 1 |
| 8 | Cerebrospinal Fluid Leakage During Transsphenoidal Surgery: Postoperative External Lumbar Drainage Reduces the Risk for Meningitis显示文摘 | M. O. van Aken R. A. Feelders S. Marie J. H. van Berge A.H.G. Dallenga E. J. Delwel R.M.L. Poublon J. A. Romijn A. J. van der Lely S.W.J. Lamberts W. W. de Herder | 2004 | Pituitary2004，，2： | 1 |
| 9 | Infectivity of human immunodefi- ciency virus-l,hepatitis C virus and'hepatitis B virus and risk of transmission by transfusion显示文摘 | Kleinman SH Lelie N Busch MP | 2009 | Transfusion2009，49，11： | 1 |
| 10 | BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge显示文摘 | Husson I Rangon CM Lelièvre V | 2005 | Cereb Cortex2005，15，3： | 1 |
| 11 | Utility of brain natriuretic peptide as prognostic marker in community-acquired pneumonia and chronic obstructive pulmonary disease exacerbation patients presenting to the emergency department显示文摘 | Leli C | 2011 | Infez Med2011，19，4： | 1 |
| 12 | Phytoremediation: plant-endophyte partnerships take the challenge显示文摘 | Weyens N van der Lelie D Taghavi S | 2009 | Current Opinion in Biotechnology2009，20，2： | 1 |
| 13 | Heart rate and autonomic balance during stand tests before and after fighter combat missions 显示文摘 | Dussault C Lely L Langrume C | 2009 | Aviat Space Environ Med2009，80，9： | 1 |
| 14 | Apolipoprotein E4 gen- otype increases the risk of postoperative cognitive dysfunction in pa- tients undergoing coronary artery bypass graft surgery显示文摘 | Lelis R G Krieger J E Pereira A C | 2006 | J Card- iovasc Surg (Torino)2006，47，4： | 1 |
| 15 | Proliferative actions of natriuretic peptides on neuroblastoma cells involvement of guanylyl cyclase and non-guanylyl cyclase pathways 显示文摘 | Leli eyre V Pineau N Hu Z | 2001 | J BioI Chern2001，276，43： | 1 |
| 16 | Typing of nosocomial out breaks of Acinetobacter baurnannii by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry显示文摘 | Mencacci A Monari C Leli C | 2013 | J Clin- Microbiol2013，51，2： | 1 |
| 17 | Biological, Physiological, Pathophysiological,and Pharmacological Aspects of Ghrelin显示文摘 | Van der Lely AJ | 2004 | Endocr Rev2004，25，3： | 1 |
| 18 | Phytoremediation: plant-endophyte partnerships take the challenge 显示文摘 | Weyens N van der Lelie D Taghavi S | 2009 | Current Opinion inBiotechnology2009，20，： | 1 |
| 19 | Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis显示文摘 | H Printz A. Saluja U. Leli A. Sengupta M. Steer | 1990 | International Journal of Pancreatology1990，，3： | 1 |
| 20 | Dealing with the masses:A tutorial on accu- rate masses, mass uncertainties, and mass defects 显示文摘 | Lelie AD Volmer DA | 2007 | Spectroscopy2007，22，： | 1 |
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