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| 1 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 2 | Regulation of iron metabolism in the acute-phase response:interferon gamma and tumour necrosis factor alpha induce hypoferraemia,ferritin production and a decrease in circulating transferrin receptors in cancer patients显示文摘 | Vreugdenhil G Eggermont AM | 1998 | Eur J Clin Invest1998，28，7： | 1 |
| 3 | Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease显示文摘 | Feelders RA de Bruin C Pereira AM | 2010 | N Engl J Med2010，362，19： | 1 |
| 4 | Cerebrospinal Fluid Leakage During Transsphenoidal Surgery: Postoperative External Lumbar Drainage Reduces the Risk for Meningitis显示文摘 | M. O. van Aken R. A. Feelders S. Marie J. H. van Berge A.H.G. Dallenga E. J. Delwel R.M.L. Poublon J. A. Romijn A. J. van der Lely S.W.J. Lamberts W. W. de Herder | 2004 | Pituitary2004，，2： | 1 |
| 5 | Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas显示文摘 | de Bruin C Pereira AM Feelders RA | 2009 | J Clin Endocrinal Metab2009，94，4： | 1 |
| 6 | Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease显示文摘 | Feelders RA de Bruin C Pereia AM | | 0，，19： | 1 |
| 7 | Transport of iron in the blood-brain-cerebrospinal fluid system显示文摘 | Feelder R A | 1997 | J Neurochem1997，69，2： | 1 |
| 8 | Learning Bayesian network parameters under order eonstraints显示文摘 | Feelders A van der Gaag L C | 2006 | International Journal of Approximate Reasoning2006，42，1： | 1 |
| 9 | Risk factors for hemodynamic instability during surgery for pheochromo- cytoma显示文摘 | Bruynzeel H Feelders RA Groenland TH | 2010 | J Clin Endocrinol Metab2010，95，2： | 1 |
| 10 | Pituitary tumours: the sst/D2 receptors as molecular targets 显示文摘 | Hofland LJ Feelders RA de Herder WW | 2010 | Mol Cell Endocrinol2010，326，12： | 1 |
| 11 | Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome 显示文摘 | de Bruin C Feelders RA Lamberts SW | 2009 | Rev Endocr Metab Disord2009，10，2： | 1 |
| 12 | Cerebrospinalflu-id leakage during transsphenoidal surgery : postoperativeexternal lumbar drainage reduces the risk for meningitis 显示文摘 | van Aken MO Feelders RA de Marie S | 2004 | Pituitary2004，7，2： | 1 |
| 13 | , A general model for automated business diagnosis 显示文摘 | Feelders A J and Daniels H A M | 2001 | European Journal of Operational Research2001，，3： | 1 |
| 14 | Medical treatment of Cushing's disease显示文摘 | Feelders RA Hofland LJ | 2013 | J Clin Endocrinol Metab2013，98，2： | 1 |
| 15 | A general model for automated business diagnosis 显示文摘 | Feelders· A· J Daniels· A· H·M | 2001 | European Journal of Operational Research2001，130，3： | 1 |
| 16 | Incidence of venous thromboembolism in patients with Cushing's syndrome: a multicenter cohort study显示文摘 | Stuijver DJ van Zaane B Feelders RA | 2011 | J Clin Endocrinol Metab2011，96，11： | 1 |
| 17 | Structure,function and clinical significance of transferrin receptors显示文摘 | Feelders RA Kuiper-Kramer EP van Eijk HG | 1999 | Clin Chem Lab Med1999，37，： | 1 |
| 18 | Diagnostic imaging of dopamine receptors in pituitary, adenomas 显示文摘 | de Herder WW Reijs AE Feelders RA et at | 2007 | Eur J Endocrinol2007，157，4： | 1 |
| 19 | Medical Treatment of Cushing ~ Disease 显示文摘 | Feelders Richard A Hofland | 2013 | J Clin Endocrinol Metab2013，98，2： | 1 |
| 20 | Thyroid hormone concentrations,disease,physical function,and mortality in elderly men显示文摘 | van den Beld AW Visser TJ Feelders RA Grobbee DE Lamberts SW | 2005 | J Clin Endocrinol Metab2005，90，12： | 1 |
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