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| 1 | Unbiased subgenome evolution following a recent whole-genome duplication in pear(Pyrus bretschneideri Rehd.)显示文摘Genome fractionation(also known as diploidization)frequently occurs following paleopolyploidization events.Biased fractionation between subgenomes has been found in some paleo-allopolyploids,while this phenomenon is absent in paleo-autopolyploids.Pear(Pyrus bretschneideri Rehd.)experienced a recent whole-genome duplication(WGD,~30 million years ago);however,the evolutionary fate of the two subgenomes derived from this WGD event is not clear.In this study,we identified the two paleo-subgenomes in pear using peach(Prunus persica)as an outgroup and investigated differences in the gene loss rate,evolutionary rate,gene expression level,and DNA methylation level between these two subgenomes.Fractionation bias was not found between the two pear subgenomes,which evolved at similar evolutionary rates.The DNA methylation level of the two subgenomes showed little bias,and we found no expression dominance between the subgenomes.However,we found that singleton genes and homeologous genes within each subgenome showed divergent evolutionary patterns of selective constraints,expression and epigenetic modification.These results provide insights into subgenome evolution following paleopolyploidization in pear. | Qionghou Li Xin Qiao Hao Yin Yuhang Zhou Huizhen Dong Kaijie Qi Leiting Li Shaoling Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 2 | Regulation of actin cytoskeleton via photolithographic micropatterning显示文摘Actin cytoskeleton plays crucial roles in various cellular functions.Extracellular matrix(ECM)can modulate cell morphology by remodeling the internal cytoskeleton.To define how geometry of ECM regulates the organization of actin cytoskeleton,we plated individual NIH 3T3 cells on micropatterned substrates with distinct shapes and sizes.It was found that the stress fibers could form along the nonadhesive edges of T-shaped pattern,but were absent from the opening edge of V-shaped pattern,indicating that the organization of actin cytoskeleton was dependent on the mechanical environment.Furthermore,a secondary actin ring was observed on 50μm circular pattern while did not appear on 30μm and 40μm pattern,showing a size-dependent organization of actin cytoskeleton.Finally,osteoblasts,MDCK and A549 cells exhibited distinct organization of actin cytoskeleton on T-shaped pattern,suggesting a cell-type specificity in arrangement of actin cytoskeleton.Together,our findings brought novel insight into the organization of actin cytoskeleton on micropatterned environments. | Fulin Xing Haimei Zhang Mengyu Li Hao Dong Xuehe Ma Shiyu Deng Fen Hu Imshik Lee Leiting Pan Jingjun Xu | 2023 | Journal of Innovative Optical Health Sciences2023，16，2： | 1 |
| 3 | Effect of nano-CaO particle on the microstructure,mechanical properties and corrosion behavior of lean Mg-1Zn alloy显示文摘The effects of nano-CaO contents on the microstructure,mechanical properties and corrosion resistance of lean Mg-1Zn alloy were investigated.The results showed that the addition of nano-CaO significantly refined the grain size and improved mechanical properties of the Mg-1Zn alloy.At the same time,CaO reacted with molten Mg in situ to form nano-MgO,whose corrosion product in SBF solution was the same with the degradation product of Mg matrix,resulting in the enhanced compactness of the Mg(OH)_(2) layer and reduced corrosion rate of matrix.The Mg-1Zn alloy had lower corrosion resistance due to excessively large grain size and shedding of corrosion products.The composite with 0.5 wt.%CaO had the best corrosion resistance with a weight loss of 9.875 mg·y^(-1)·mm^(-2)due to the small number of Ca_(2)Mg_(6)Zn_(3) phase and suitable grain size.While for composites with high content of CaO(0.7 wt.%and 1.0 wt.%),they had lower corrosion resistance due to the coexistence of large number of Ca_(2)Mg_(6)Zn_(3) and Mg_(2)Ca at grain boundaries,especially for 1.0 wt.%CaO composite,resulting from the strong micro-galvanic corrosion. | Guangxin Shen Shaoyuan Lyu Leiting Yu Tianlu Li Chen You Xuewei Wang Minfang Chen Bin Jiang | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
| 4 | Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation显示文摘In fluorescence microscopy,computational algorithms have been developed to suppress noise,enhance contrast,and even enable super-resolution(SR).However,the local quality of the images may vary on multiple scales,and these differences can lead to misconceptions.Current mapping methods fail to finely estimate the local quality,challenging to associate the SR scale content.Here,we develop a rolling Fourier ring correlation(rFRC)method to evaluate the reconstruction uncertainties down to SR scale.To visually pinpoint regions with low reliability,a filtered rFRC is combined with a modified resolution-scaled error map(RSM),offering a comprehensive and concise map for further examination.We demonstrate their performances on various SR imaging modalities,and the resulting quantitative maps enable better SR images integrated from different reconstructions.Overall,we expect that our framework can become a routinely used tool for biologists in assessing their image datasets in general and inspire further advances in the rapidly developing field of computational imaging. | Weisong Zhao Xiaoshuai Huang Jianyu Yang Liying Qu Guohua Qiu Yue Zhao Xinwei Wang Deer Su Xumin Ding Heng Mao Yaming Jiu Ying Hu Jiubin Tan Shiqun Zhao Leiting Pan Liangyi Chen Haoyu Li | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 5 | Effect of surface passivation on optical and electronic properties of ultrathin silicon nanosheets显示文摘The binding energy,electronic structure and optical properties of H-,H 3 C-,and HS-cluster-passivated ultrathin silicon (single-layer and double-layer) nanosheets were calculated using density functional theory based on the plane-wave ultra-soft pseudopotential.Firstly,the most stable configuration was selected from passivated configurations according to the principle of lowest energy after calculating their total energies.Then the density of state and the band structure of the different passivated systems were calculated.It was found that different passivation clusters could affect the forbidden band,theremore the passivated cluster with sulfur could greatly decrease the width of the forbidden band through electron transfer.Lastly,the light absorption and reflection properties were also investigated.All results were conducive to the development of silicon-based optoelectronic devices. | WANG Le WU Ke DONG QianMin LI XiaoYan XIONG SiYu XU LeiTing LIANG Pei | 2012 | Science China(Information Sciences)2012，55，6： | 0 |
| 6 | An Experimental and Numerical Study on the Ballistic Performance of Multi-Layered Moderately-Thick Metallic Targets against 12.7-mm Projectiles显示文摘Themain goal of this work is to study the ballistic performance ofmulti-layered moderately-thick metallic targets.Several target configurations have been considered in thiswork,with various types of interlayer connection(spaced,contacted and adhesive)and the number of layers(four and eight),and the influence of target configurations on ballistic performance has been studied experimentally and numerically.In the experiments,the targets were impacted by 12.7-mm projectiles at a velocity around 820 m/s.The experimental results show that,with similar total thickness,the contacted and adhesive targets exhibit better ballistic performance than the monolithic targets,and the four-layered targets are better than the eight-layered targets with the same connection type.To explore the ballistic resistance mechanism,numerical method has been used to simulate the penetration process of each target.The numerical results indicate that petal formation and friction have significant influence on targets’ballistic performance.Friction has stronger influence on themulti-layered targets than on themonolithic ones.According to the numerical results,about 14%of projectile’s initial kinetic energy is dissipated by friction during penetrating the four-layered contacted target,which is proved to be the most effective type of target studied in thiswork.The results also indicate that,in contrast to common understanding,friction plays an important role even when the impact velocity is significantly higher than the ballistic limit.The outcome of this work may provide useful information for a better understanding of ballistic resistant mechanisms and more efficient utilization of multi-layered metallic targets in armor structural design. | Kailei Wang Mingjing Li Peng Yan Leiting Dong | 2022 | Computer Modeling in Engineering & Sciences2022，，4： | 0 |
| 7 | Ultraviolet light A irradiation induces immunosuppression associated with the generation of reactive oxygen species in human neutrophils显示文摘Ultraviolet blood irradiation has been used as a physical therapy to treat many nonspeci¯c diseases in clinics;however,the underlying mechanisms remain largely unclear.Neutrophils,the first line of host defense,play a crucial role in a variety of in°ammatory responses.In the present work,we investigated the effects of ultraviolet light A(UVA)on the immune functions of human neutrophils at the single-cell level by using an inverted°uorescence microscope.N-Formylmethionyl-leucyl-phenylalanine(FMLP),a classic physiological chemotactic peptide,was used to induce a series of immune responses in neutrophils in vitro.FMLP-induced calcium mobilization,migration,and phagocytosis in human neutrophils was significantly blocked after treatment with 365 nm UVA irradiation,demonstrating the immunosuppressive effects of UVA irradiation on neutrophils.Similar responses were also observed when the cells were pretreated with H2O2,a type of reactive oxygen species(ROS).Furthermore,UVA irradiation resulted in an increase in NAD(P)H,a member of host oxidative stress in cells.Taken together,our data indicate that UVA irradiation results in immunosuppression associated with the production of ROS in human neutrophils. | Cunbo Li Xuechen Shi Mincai Chen Guangxue Xu Xinglei Su Pengchong Jiang Leiting Pan | 2016 | Journal of Innovative Optical Health Sciences2016，9，1： | 0 |
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