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| 1 | Engineering T cells for immunotherapy of primary human hepatocellular carcinoma显示文摘Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects. | Leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 2 | 慢性阻塞性肺疾病急性加重的标准化测量显示文摘背景和目的:COPD急性加重(AECOPD)反复发生是COPD病情进展的重要原因之一,减少AECOPD发生频率也是对COPD进行干预的主要目标之一。但是到目前为止,评估AECOPD的发生频率、严重程度和持续时间尚无有效的、标准化的监测工具。 | Leidy NK Wilcox TK Jones PW 白澎 孙永昌 | 2011 | 中华结核和呼吸杂志2011，34，9： | 2 |
| 3 | The Impact of Surface Properties on Downward Surface Shortwave Radiation over the Tibetan Plateau显示文摘The complexity of inhomogeneous surface–atmosphere radiation transfer is one of the foremost problems in the field of atmospheric physics and atmospheric radiation. To date, the influence of surface properties on shortwave radiation has not been well studied. The daily downward surface shortwave radiation of the latest FLASHFlux/CERES(Fast Longwave And Shortwave Fluxes Time Interpolated and Spatially Averaged/Clouds and the Earth's Radiant Energy System) satellite data was evaluated against in situ data. The comparison indicated that the differences between the two data sets are unstable and large over rugged terrain compared with relatively flat terrain, and the mean absolute error of the satellite products reaches 31.4 W m-2(12.3%) over rugged terrain. Based on the SSF(single satellite footprint)/CERES product, the influence of surface properties on the distribution of downward surface shortwave radiation(DSSR) was analyzed. The influence of surface properties on DSSR over the Tibetan Plateau is about twice as large as that in two other regions located at the same latitude(eastern China–western Pacific and subtropical North Pacific). A simulation was carried out with the help of the I3RC(International Intercomparision of Three-Dimensional Radiation Code) Monte Carlo 3D radiative transfer community model. The results showed that DSSR increases as surface albedo increases. Moreover, the impact of surface albedo on DSSR is larger if the spatial distribution of clouds is more non-uniform. It is hoped that these results will contribute to the development of 3D radiative transfer models and the improvement of satellite inversion algorithms. | WANG Leidi L Daren HE Qing | 2015 | Advances in Atmospheric Sciences2015，32，6： | 2 |
| 4 | 肿瘤多学科团队实施现状及影响因素研究显示文摘目的了解医务工作者对于肿瘤多学科团队的态度,以及识别促进和阻碍其实施的因素。方法对武汉两家公立医院的各类肿瘤相关医务人员展开问卷调查,并运用描述性统计分析和卡方检验进行数据分析。结果 99%的受访者认为肿瘤多学科团队对病人有帮助,并且可促进医务工作者的工作。在中国的医院中实施和执行肿瘤多学科团队存在的主要阻碍因素为缺少时间(71.0%)、缺乏动机和激励因素(59.9%)和财政支持不足(57.0%);促进其实施的因素为工作人员之间的协调及沟通(68.6%)、领导能力和团队精神(63.8%)、医疗卫生工作者之间的关系(58.5%)。不同医务工作者对于影响因素的态度存在显著性差异。结论肿瘤专科医生对组建多学科团队的必要性高度认可,但有效实施需要针对缺少时间、缺乏动机、缺少财政支持、行政管理因素以及组织政策等方面的问题提出相应的对策,以促进我国肿瘤多学科团队的建设。 | Leidy Stefany Delgado 陶红兵 蔡苗 Ashleigh Chinelo Oguagha | 2017 | 中国医疗管理科学2017，7，3： | 2 |
| 5 | Germination responses of Erica andevalensis to different chemical and physical treatments显示文摘 | S. Rossini Oliva E. O. Leidi B. Valdés | 2009 | Ecological Research2009，，3： | 1 |
| 6 | Loss of Halophytism by Interference with SOS1 Expression1[W][OA]显示文摘 | Oh Dong-Ha Leidi Eduardo Zhang Quan Hwang Sung-Min Li Youzhi Quintero Francisco J Jiang Xingyu D’Urzo Matilde Paino Lee Sang Yeol Zhao Yanxiu Bahk Jeong Dong Bressan Ray A Yun Dae-Jin Pardo José M Bohnert Hans J | 2009 | Plant Physiology2009，，1： | 1 |
| 7 | Increased dietary protein consumed at breakfast leads to an initial and sustained feeling of fullness during energy restriction compared to other meal times显示文摘 | Leidy HJ Bossingham MJ Mattes RD | 2009 | Br J Nutr2009，101，6： | 1 |
| 8 | Phenotypic and genotypic characterization of rhizobia from diverse geographical origin that nodulate Pachyrhizus species, 显示文摘 | Rodriguez-Navarro D N Camacho M Leidi E O | 2004 | Syst Appl Microbiol2004，27，6： | 1 |
| 9 | The AtNHX1 exchanger mediates potassium compartmentation in vacuoles of transgenic tomato显示文摘 | Leidi E O Barragán V Rubio L | 2010 | The Plant Journal2010，61，3： | 1 |
| 10 | Salinity and nitrogen nutrition studies on peanut and cotton plants显示文摘 | Leidi E O Silberbush M Soares M M Lips S H | 1992 | Journal of Plant Nutrition1992，15，5： | 1 |
| 11 | In search of parsimony:reliability and validity of the functional performance inventory short-form显示文摘 | LEIDY N K KNEBEL A | 2010 | Int J Chron Obstruct Pulmon Dis2010，5，4： | 1 |
| 12 | Expression of wheat Na+/H+ antiporter TNHXS1 and H+-pyrophosphatase TVP1 genes in tobacco from a bicistronic transcriptional unite improves salt tolerance显示文摘 | Gouiaa S Khoudi H Leidi EO | 2012 | Plant Mol Biol2012，79，： | 1 |
| 13 | Enantiomeric and isomeric sep-aration of herbicides using cyclodextrin-modified capillary zone e-lectrophoresis显示文摘 | Penmetsa K V Leidy R B Shea D | 1997 | J Chromatogr A1997，790，12： | 1 |
| 14 | Seizure frequency and the health - related quality of life of adults with epilepsy显示文摘 | Leidy NK Elixhauser A Vickrey B | 2001 | Neurology2001，57，114： | 1 |
| 15 | In search of parsimony:reliability and validity of functional performance inventory-short form显示文摘 | Leidy NK Knebel A | 2010 | Int J Chron Obstruct Pulmon Dis2010，5，4： | 1 |
| 16 | Consuming high-protein soy snacks affects appetite control, satiety, and diet quality in young people and influences select aspects of mood and cognition显示文摘 | LEIDY H J TODD C B ZINO A Z | 2015 | J Nu- tr2015，145，7： | 1 |
| 17 | EDF-1 contributes to the regulation of nitric oxide release in VEGF-treated human endothelial cells显示文摘 | Leidi M Mariotti M Maier JA | 2010 | Eur J Cell Biol2010，89，9： | 1 |
| 18 | Effect of nitrogen source on growth response to salinity stress in maize and wheat 显示文摘 | LEWIS O A M Leidi E Q Lips S H | 1989 | New Phytologist1989，111，： | 1 |
| 19 | Cascading contingent protection显示文摘 | HOEKMAN B M LEIDY M P | 1992 | Canadian Journal of Economic1992，36，： | 1 |
| 20 | Herbicide analysis by micellar electrokinetic capillary chromatography显示文摘 | PENMETXSA K V LEIDY R B SHEA D | 1996 | J Chromatogr A1996，745，12： | 1 |
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