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| 1 | Human intestinal M cells display the sialyl lewis a antigen显示文摘 | GIANNASCA P J GIANNASCA K T LEICHTNER AM | 1999 | Infect Immun1999，67，2： | 1 |
| 2 | Allergic colitis in infants显示文摘 | Odze RD Wershil BK Leichtner AM | 1995 | J Pediatr1995，126，2： | 1 |
| 3 | Complementary medicine use in children and young adults with inflammatory bowel disease显示文摘 | Heuschkel R Afzal N Wuerth A Zurakowski D Leichtner A and Kemper K | 2002 | Am J Gastroenterol2002，97，： | 1 |
| 4 | Allergic colitis in in- fants显示文摘 | Odze RD Wershil BK Leichtner AM | 1995 | J Pediatr1995，126，2： | 1 |
| 5 | Human intestinal M cells display the sialyl Lewis A antigen显示文摘 | Giannasca PJ Giannasca KT Leichtner AM | 1999 | Infect Immu1999，67，： | 1 |
| 6 | First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study显示文摘 | Dehlink E Yen E Leichtner A M | 2009 | Clin Exp Allergy2009，39，： | 1 |
| 7 | 显示文摘 | Kuhnelt M Leichtner T Kaiser S | 1998 | Appl Phys Lett1998，73，： | 1 |
| 8 | Vitamins A and E Serum Levels in Children and Young Adults with Inflammatory Bowel Disease: Effect of Disease Activity显示文摘 | Athos Bousvaros David Zurakowski Christopher Duggan Terry Law Nader Rifai Nancy E. Goldberg Alan M. Leichtner | 1998 | Journal of Pediatric Gastroenterology & Nutrition1998，，2： | 1 |
| 9 | Gastrointestinal manifestations of vascular anomalies in childhood: Varied etiologies require multiple therapeutic modalities 显示文摘 | Burrows PE Leichtner AM | 1998 | J Pediatr Surg1998，33，： | 1 |
| 10 | Assessment Tools:the Next Frontier in Competency-Based Medical Education 显示文摘 | Robson J Leichtner AM Sauer CG | 2014 | J Pediatr Gastroenterol Nutrit2014，59，4： | 1 |
| 11 | Discordance for biliary atresia in two sets of monozygotic twins 显示文摘 | Hyams JS Glaser JH Leichtner AM | 1985 | J Pedi- atr1985，107，： | 1 |
| 12 | Allergic colitis in infants 显示文摘 | Odze RD Wershil BK Leichtner AM | 1995 | J Pediatr1995，126，2： | 1 |
| 13 | Serum Basic Fibroblast Growth Factor in Pediatric Crohn’s Disease (Implications for Wound Healing)显示文摘 | Athos Bousvaros David Zurakowski Steven J. Fishman Karen Keough Terry Law Christina Sun Alan M. Leichtner | 1997 | Digestive Diseases and Sciences1997，，2： | 1 |
| 14 | Pseudopheochro- mocytoma and cardiac arrest associated with phenylpropanolamine 显示文摘 | Hyams JS Leichtner AM Breiner RG | 1985 | JAMA1985，253，11： | 1 |
| 15 | Gastrointestinal manifestations of vascular anomalies in childhood: varied etiologies require multiple therapeutic modalities 显示文摘 | Fishman SJ Burrows PE Leichtner AM | 1998 | J Pediatr Surg1998，33，： | 1 |
| 16 | Surgery for Crohn's in infant and children显示文摘 | Patel H I Leichtner A M Colodny AH | 1997 | J Pediatr Surg1997，32，： | 1 |
| 17 | Non-responsive celiac disease in children on a gluten free diet显示文摘BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric population.AIM To determine the incidence, clinical characteristics and underlying causes of NRCD in children.METHODS Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children < 18 years diagnosed with CeD by positive serology and duodenal biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD therapy.RESULTS Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD improved on follow-up.CONCLUSION NRCD after ≥ 6 mo GFD is frequent among children, especially females, and is associated with initial presenting symptoms of constipation and/or abdominal pain. Gluten exposure is the most frequent cause. | Gopal Veeraraghavan Amelie Therrien Maya Degroote Allison McKeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler Alan M Leichtner Ciaran P Kelly Dascha C Weir | 2021 | World Journal of Gastroenterology2021，27，13： | 0 |
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