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| 1 | Achieving over 16% efficiency for single-junction organic solar cells显示文摘To achieve high photovoltaic performance of bulk hetero-junction organic solar cells(OSCs), a range of critical factors including absorption profiles, energy level alignment, charge carrier mobility and miscibility of donor and acceptor materials should be carefully considered. For electron-donating materials, the deep highest occupied molecular orbital(HOMO) energy level that is beneficial for high open-circuit voltage is much appreciated. However, a new issue in charge transfer emerges when matching such a donor with an acceptor that has a shallower HOMO energy level. More to this point, the chemical strategies used to enhance the absorption coefficient of acceptors may lead to increased molecular crystallinity, and thus result in less controllable phase-separation of photoactive layer. Therefore, to realize balanced photovoltaic parameters, the donor-acceptor combinations should simultaneously address the absorption spectra, energy levels, and film morphologies. Here, we selected two non-fullerene acceptors, namely BTPT-4F and BTPTT-4F, to match with a wide-bandgap polymer donor P2F-EHp consisting of an imidefunctionalized benzotriazole moiety, as these materials presented complementary absorption and well-matched energy levels. By delicately optimizing the blend film morphology, we demonstrated an unprecedented power conversion efficiency of over 16% for the device based on P2F-EHp:BTPTT-4F, suggesting the great promise of materials matching toward high-performance OSCs. | Baobing Fan Difei Zhang Meijing Li Wenkai Zhong Zhaomiyi Zeng Lei Ying Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，6： | 38 |
| 2 | Laparoscopic total mesorectal excision of low rectal cancer with preservation of anal sphincter:A report of 82 cases显示文摘AIM: To assess the feasibility and efficacy of laparoscopic total mesorectal excision (LTME) of low rectal cancer with preservation of anal sphincter.METHODS: From June 2001 to June 2003, 82 patients with low rectal cancer underwent laparoscopic total mesorectal excision with preservation of anal sphincter. The lowest edge of tumors was below peritoneal reflection and 1.5-7 cm from the dentate line (1.5-5 cm in 48 cases, 5-7 cm in 34 cases).RESULTS: LTME with anal sphincter preservation was performed on 82 randomized patients with low rectal cancer, and 100 % sphincter preservation rate was achieved. There were 30 patients with laparoscopic low anterior resection (LLAR) at the level of the anastomosis below peritoneal reflection and 2 cm above from the dentate line; 27 patients with laparoscopic ultralow anterior resection (LULAR) at the level of anastomoses 2 cm below from the dentate line; and 25 patients with laparoscopic coloanal anastomoses (LC AA) at the level of the anastomoses at or below the dentate line. No defunctioning ileostomy was created in any case. The mean operating time was 120 minutes (ranged from 110-220 min), and the mean operative blood loss was 20 mL (ranged from 5-120 mL).Bowel function was restored and diet was resumed on day 1 or 2 after operation. The mean hospital stay was 8 days (ranged from 5-14). Postoperative analgesics were used in 45 patients. After surgery, 2 patients had urinary retention, one had anastomotic leakage, and another 2patients had local recurrence one year later. No interoperative complication was observed.CONCLUSION: LTME with preservation of anal sphincter is a feasible, safe and minimally invasive technique with less postoperative pain and rapid recovery, and importantly, it has preserved the function of the sphincter. | Zong-Guang Zhou Zhao Wang Yong-Yang Yu Ye Shu Zhong Cheng Li Li Wen-Zhang Lei Tian-Cai Wang Department of General Surgery and Institute of Digestive Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China | 2003 | World Journal of Gastroenterology2003，9，7： | 33 |
| 3 | Seasonal variation of potential denitrification rates of surface sediment from Meiliang Bay, Taihu Lake, China显示文摘The regulatory effects of environmental factors on denitrification were studied in the sediments of Meiliang Bay, Taihu Lake, in a monthly sampling campaign over a one-year period. Denitrification rates were measured in slurries of field samples and enrichment experiments using the acetylene inhibition technique. Sediment denitrification rates in inner bay and outer bay ranged from 2.8 to 51.5 nmol N2/(g dw (dry weight)·hr) and from 1.5 to 81.1 nmol N2/(g dw·hr), respectively. Sediment denitrification rates were greatest in the spring and lowest in the summer and early autumn, due primarily to seasonal differences in nitrate concentration and water temperature. For each site, positive and linear relationships were regularly observed between denitrification rate and water columnn itrate concentration. Of various environmental factors on denitrification that we assessed, nitrate was determined to be the key factor limiting denitrification rates in the sediments of Meiliang Bay. In addition, at the two sites denitrification rates were also regulated by temperature. The addition of organic substrates had no significant effect on denitrification rate, indicating that sediment denitrification was not limited by organic carbon availability in the sediments. Nitrate in the water column was depleted during summer and early autumn, and this suppressed effective removal of nitrogen from Taihu Lake by denitrification. | Jicheng Zhong, Chengxin Fan, Guofeng Liu, Lei Zhang, Jingge Shang, Xiaozhi GuState Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. | 2010 | Journal of Environmental Sciences2010，22，7： | 29 |
| 4 | Tong xie yao fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P显示文摘AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity.in normal rats and 4.5 ± 1.58 in IBS model rats(P < 0.001). However, the defecation frequency was significantly decreased(3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS. | Yue Yin Lei Zhong Jian-Wei Wang Xue-Ying Zhao Wen-Jing Zhao Hai-Xue Kuang | 2015 | World Journal of Gastroenterology2015，21，15： | 29 |
| 5 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 6 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 7 | Correlation of burial organic carbon and paleoproductivity in the Mesoproterozoic Hongshuizhuang Formation, northern North China显示文摘In general, total organic carbon (TOC) is directly used as a proxy for paleoproductivity, however, it is not only affected by paleoproductivity, but also controlled by redox conditions and terrigenous detrital matter influx. Major and trace elements were analysed with the purpose of investigating the redox potential and paleoproductivity during deposition of the Hongshuizhuang Formation. In the present study, C-S relationship, V/Cr ratio and Mo concentration indicate that the dolomites were deposited in oxic environments, however, most of the black shales were accumulated in euxinic environments. P/Ti values in the Hongshuizhuang samples can be compared with those in the Japanese Ubara Permian-Triassic section which were regarded to be deposited under a moderate to high paleoproductivity. Ba/Al values are slightly lower than that of the laminated sediments from the continental margins of Central California (CCAL) which were thought to be accumulated under a high paleoproductivity. These results indicate that the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation. Burial organic carbon shows positive correlations with V/Cr and Mo, but shows only weakly or no correlation with P/Ti and Ba/Al, respectively, suggesting that although the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation, its organic-rich sediments were predominantly controlled by redox conditions and had no direct relationship with paleoproductivity. | LUO QingYong ZHONG NingNing ZHU Lei WANG YanNian QIN Jing QI Lin ZHANG Yi MA Yong | 2013 | Chinese Science Bulletin2013，58，11： | 17 |
| 8 | Strain and kinematic vorticity analysis:An indicator for sinistral transpressional strain-partitioning along the Lancangjiang shear zone,western Yunnan,China显示文摘This work deals with the preliminary relationship between strain path and strain partitioning pattern in a sinistral transpressional zone,Lancangjiang shear zone,located to the southeast of Tibet.Various ductile rocks provide an opportunity to investigate quantitative finite strain(Rs),kinematic vorticity values(Wm),and proportions of simple and pure shear components.The mean kinematic vorticity values(Wm) were evaluated based on three methods,such as Rs-θ,prophyroclast hyperbolic distribution method(PHD),and polar Mohr diagram construction(PMD).Wm for mylonitic metasediments of the low-grade schist belt ranged from 0.19 to 0.54.Protomylonites,mylonites,and ultramylonites recorded differential Wm values,0.19―0.73,0.11―0.8,and 0.84―0.95(even 0.99) respectively in the high-grade gneiss belt.Based on classical strain analysis and these kinematic vorticity evaluations,the shear zone is classified as a preliminarily bulk monoclinic symmetry.The pattern of vorticity path suggests that a previously undocumented transpressional setting and strain partitioning pattern in the southeast region of Tibet Plateau,characterized by steep-narrow domain of simple-shearing(Tertiary strike-slip shearing) deformation and wider domain of mostly pure-shearing(Tertiary contraction) to accommo-date intracontinental deformation. | Bo Zhang JinJiang Zhang DaLai Zhong Lei Guo | 2009 | Science China Earth Sciences2009，52，5： | 16 |
| 9 | The Prevalence of Nonalcoholic Fatty Liver Disease and its Association with Lifestyle/dietary Habits among University Faculty and Staff in Chengdu显示文摘Objective To investigate the prevalence of nonalcoholic fatty liver disease(NAFLD) in different university categories and its association with lifestyle/dietary habits.Methods A cross-sectional study was carried out on 9 378 faculty members and staff who participated in an annual health checkup at three universities selected by random cluster sampling.Demographic,anthropometric,biochemical indices and abdominal ultrasound measurements were collected.A nested case-control study was conducted with 200 NAFLD cases and 200 controls matched by gender,age(±3 years),and university.Results The overall prevalence of NAFLD was 10.3%(13.7% in males and 6.8% in females).The prevalence was significantly higher in the science and engineering university(22.1%) than in the comprehensive universities with(6.4%) and without(10.9%) medical colleges.Obesity/overweight,hyperlipidemia,diabetes mellitus,and family history of NAFLD were independently associated with higher risk of NAFLD,as were frequent consumption of desserts and salty/spicy foods.Using nutritional supplements was a protective factor against NAFLD.Intake of coarse cereals,potatoes,vegetables,fruits,and milk was significantly lower,and intake of red meat,viscera,candies and pastries,cooking oil,and total energy was significantly higher in participants with NAFLD than in controls.Conclusion Science and engineering university faculty and staff are key targets for NAFLD prevention.NAFLD is closely associated with age,gender,university type,metabolic diseases,and lifestyle/dietary habits. | SHI Lei LIU Zhong Wu LI Yun GONG Cai ZHANG Huan SONG Li Juan HUANG Cheng Yu LI Ming | 2012 | Biomedical and Environmental Sciences2012，25，4： | 16 |
| 10 | Potential role of strike-slip faults in opening up the South China Sea显示文摘Radiometric dates of key rock units indicate that a remnant Late Mesozoic ocean of the Huatung Basin is still preserved today east of the South China Sea(SCS).We integrate regional geology with a Cretaceous oceanic basement in the vicinity of the Huatung Basin to reconstruct the Huatung Plate east of the Eurasian continent.Results of geophysical investigations,four expeditions of deep-sea drilling and a renaissance of regional geology allow us to propose a hypothesis that the mechanism responsible for the SCS opening was raised from strike-slip fault on the east.The hypothesis suggests that the SCS opening could highly relate to the strike-slip faults inherited from Late Mesozoic structures onshore–offshore the SE Cathaysia Block to develop rhombic-shaped extensional basins en echelon on the thinned Eurasian continental crust in the Early Cenozoic.It was followed by sinistral strike-slip movements along the boundary between the Eurasian Plate and the Huatung Plate driven by oblique subduction of the Huatung Plate to the northwest coupled with slab-pull force by southward subduction of the Proto-SCS to open up the triangle-shaped oceanic East Sub-basin in the Early Oligocene(33/34 Ma).The spreading ridge then propagated southwestward in the step-over segment between the Zhongnan-Lile and the Red River strike-slip fault systems to open the triangle-shaped oceanic Southwest Sub-basin by 23 Ma.The plate boundary fault was subsequently converted into the Manila Trench when the Eocene Sierra Madre arc of the Huatung Plate had moved from the south to its present latitude by the Middle Miocene. | Chi-Yue Huang Pinxian Wang Mengming Yu Chen-Feng You Char-Shine Liu Xixi Zhao Lei Shao Guangfa Zhong Graciano P.Yumul Jr | 2019 | National Science Review2019，6，5： | 16 |
| 11 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 12 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 13 | Colostomy is a simple and effective procedure for severe chronic radiation proctitis显示文摘AIM: To assess the efficacy and safety of diverting colostomy in treating severe hemorrhagic chronic radiation proctitis(CRP). METHODS: Patients with severe hemorrhagic CRP who were admitted from 2008 to 2014 were enrolled into this study. All CRP patients were diagnosed by a combination of pelvic radiation history, clinical rectal bleeding, and endoscopic findings. Inclusion criteria were CRP patients with refractory bleeding with moderate to severe anemia with a hemoglobin level < 90 g/L. The study group included patients who were treated by diverting colostomy, while the control group included patients who received conservative treatment. The remission of bleeding was defined as complete cessation or only occasional bleeding that needed no further treatment. The primary outcome was bleeding remission at 6 mo after treatment. Quality of life beforetreatment and at follow-up was evaluated according to EORTC QLQ C30. Severe CRP complications were recorded during follow-up.RESULTS: Forty-seven consecutive patients were enrolled, including 22 in the colostomy group and 27 in the conservative treatment group. When compared to conservative treatment, colostomy obtained a higher rate of bleeding remission(94% vs 12%), especially in control of transfusion-dependent bleeding(100% vs 0%), and offered a better control of refractory perianal pain(100% vs 0%), and a lower score of bleeding(P < 0.001) at 6 mo after treatment. At 1 year after treatment, colostomy achieved better remission of both moderate bleeding(100% vs 21.5%, P = 0.002) and severe bleeding(100% vs 0%, P < 0.001), obtained a lower score of bleeding(0.8 vs 2.0, P < 0.001), and achieved obvious elevated hemoglobin levels(P = 0.003), when compared to the conservative treatment group. The quality of life dramatically improved after colostomy, which included global health, function, and symptoms, but it was not improved in the control group. Pathological evaluation after colostomy found diffused chronic inflammation cells, and massive fibrosis collagen depositions under the rectal wall, which revealed potential fibrosis formation. CONCLUSION: Diverting colostomy is a simple, effective and safe procedure for severe hemorrhagic CRP. Colostomy can improve quality of life and reduce serious complications secondary to radiotherapy. | Zi-Xu Yuan Teng-Hui Ma Huai-Ming Wang Qing-Hua Zhong Xi-Hu Yu Qi-Yuan Qin Jian-Ping Wang Lei Wang | 2016 | World Journal of Gastroenterology2016，22，24： | 14 |
| 14 | Genome Sequences Provide Insights into the Reticulate Origin and Unique Traits of Woody Bamboos显示文摘Polyploidization is a major driver of speciation and its importance to plant evolution has been well recognized.Bamboos comprise one diploid herbaceous and three polyploid woody lineages,and are members of the only major subfamily in grasses that diversified in forests,with the woody members having a tree-like lignified culm.In this study,we generated four draft genome assemblies of major bamboo lineages with three different ploidy levels(diploid,tetraploid,and hexaploid).We also constructed a high-density genetic linkage map for a hexaploid species of bamboo,and used a linkage-map-based strategy for genome assembly and identification of subgenomes in polyploids.Further phylogenomic analyses using a large dataset of syntenic genes with expected copies based on ploidy levels revealed that woody bamboos originated subsequent to the divergence of the herbaceous bamboo lineage,and experienced complex reticulate evolution through three independent allopolyploid events involving four extinct diploid ancestors.A shared but distinct subgenome was identified in all polyploid forms,and the progenitor of this subgenome could have been critical in ancient polyploidizations and the origin of woody bamboos.Important genetic clues to the unique flowering behavior and woody trait in bamboos were also found.Taken together,our study provides significant insights into ancient reticulate evolution at the subgenome level in the absence of extant donor species,and offers a potential model scenario for broad-scale study of angiosperm origination by allopolyploidization. | Zhen-Hua Guo Peng-Fei Ma Guo-Qian Yang Jin-Yong Hu Yun-Long Liu En-Hua Xia Mi-Cai Zhong Lei Zhao Gui-Ling Sun Yu-Xing Xu You-Jie Zhao Yi-Chi Zhang Yu-Xiao Zhang Xue-Mei Zhang Meng-Yuan Zhou Ying Guo Cen Guo Jing-Xia Liu Xia-Ying Ye Yun-Mei Chen Yang Yang Bin Han Choun-Sea Lin Ying Lu De-Zhu Li | 2019 | Molecular Plant2019，12，10： | 13 |
| 15 | Biphasic effects of sodium danshensu on vesse function in isolated rat aorta显示文摘 | Ning ZHANG Hao ZOU Lei JIN Jian WANG Mei-fang ZHONG Peng HUANG Bing-qing GU Shi-long MAO Chuan ZHANG Hong CHEN | 2010 | Acta Pharmacologica Sinica2010，31，4： | 13 |
| 16 | Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel- group and controlled clinical trial显示文摘 | Cao Yong-jun Zhang Xia Wang Wan-hua Zhai Wan-qing Qian Ju-fen Wang Jian-sheng Chen Jun You Nian-xing Zhao Zhong Wu Qiu-yi Xu Yuan Yuan Lei Li Rui-xia Liu Chun-feng | 2013 | Chinese Medical Journal2013，，21： | 13 |
| 17 | Imaging diagnosis of pancreato-biliary diseases: A control study显示文摘AIM: To evaluate the clinical value of various imageological methods in diagnosing the pancreato-biliary diseases and to seek the optimal procedure.METHODS: Eighty-two cases of pancreato-biliary diseases confirmed by surgery and pathology were analyzed. There were 38 cases of cholelithiasis, 34 cases of pancreato-biliary tumors and 10 other cases. The imageological methods included B-US, CT, ERCP, PTC, cross-sectional MRI and MR cholangiopancreatography (MRCP).RESULTS: The accuracy rate of MRCP in detecting the location of pancreato-biliary obstruction was 100 %. In differentiating malignant from benign obstruction, the sensitivity of the combination of MRCP and cross-sectional MRI was 82.3 %, the specificity was 93.8 %, and the accuracy rate was 89.0 % . The accuracy rate for determining the nature of obstruction was 87.8 %, which was superior to that of B-US (P=0.0000) and CT (P=0.0330),but there was no significant difference between direct cholangiopancreatography and the combination of MRCP and conventional MRI (P=0.6666).CONCLUSION: In most cases, MRCP can substitute direct cholangiopancreatography for diagnosis. The combination of MRCP and cross-sectional MRI should be considered as an important means in diagnosing the pancreato-biliary diseases, pre-operative assessment and post-operative follow-ups. | Liang Zhong Qiu-Ying Yao Lei Li Jian-Rong Xu Department of Radiology,Renji Hospital,Shanghai Second Medical University,Shanghai 200001,China | 2003 | World Journal of Gastroenterology2003，9，12： | 13 |
| 18 | USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA显示文摘圈套(也作为 MITA 知道) 调停天生的抗病毒的发信号和圈套的 ubiquitination 对它的功能关键。然而,圈套的 deubiquitination 过程是不清楚的。这里,我们报导那 USP18 成员 USP20 到连接 K48 的 ubiquitination 从圈套锁住并且支持的 deconjugate 圈套和类型的表示的稳定性我在 DNA 病毒感染以后的 IFN 和 proinflammatory cytokines。USP18 缺乏或 USP20 击倒导致了提高的连接 K48 的 ubiquitination 并且加速了圈套的降级,并且与 DNA 病毒 HSV-1 或各种各样的 DNA ligands 的 transfection 在感染以后损害了下游的基因的 IRF3 和 NF-B 以及正式就职的激活。另外, Usp18 / 老鼠与野类型的同窝出生的人相比更产生 HSV-1 感染。USP18 deubiquitinate 没在 vitro 叮,但是便于 USP20 在 USP18 的酶的活动的一个方式独立人士催化圈套的 deubiquitination。另外,进 Usp18 / MEF 的圈套的宪法恢复了下游的基因和细胞的抗病毒的回答的 HSV-1-induced 表示。我们的调查结果因此以前揭开在调停的 USP18 和 USP20 的 uncharacterized 角色被触发病毒的发信号并且贡献天生的抗病毒的回答的复杂规章的系统的理解。 | Man Zhang Meng-Xin Zhang Qiang Zhang Gao-Feng Zhu Lei Yuan Dong-Er Zhang Qiyun Zhu Jing Yao Hong-Bing Shu Bo Zhong | 2016 | Cell Research2016，26，12： | 12 |
| 19 | Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation显示文摘在稳固的肿瘤的本地组织缺氧经常导致抵抗到放射疗法(RT ) ,在哪个氧为提高 DNA 损坏的一个必要元素被电离引起放射。此处,我们开发了 gold@manganese 二氧化物(有聚乙烯乙二醇(木钉) 的 Au@MnO 2) 核心壳 nanoparticles 是的涂层在癌症治疗期间改进 RT 功效的一个新奇 radiosensitizing 代理人。在这 Au@MnO 2 nanostructure ,当金核心是著名 RT 时,交往与的 sensitizer X光检查为在 RT 下面杀死的改进癌症生产控告的粒子, MnO 2壳可以触发内长的 H 2在肿瘤微型环境到的 O 2产生氧并且克服 hypoxiaassociated RT 抵抗。是示威了由在 vitro 并且在 vivo 实验, Au@MnO 2-PEG nanoparticles 充当了有效 radiosensitizers 显著地在 RT 期间提高癌症治疗功效。而且, Au@MnO 2-PEG 的明显的副作用都没在老鼠被观察。因此,我们的工作为 hypoxic 肿瘤的提高的 RT 治疗与潜力介绍 radiosensitizer 的一种新类型。 | Xuan Yi Lei Chen Xiaoyan Zhong Roulin Gao Yitao Qian Fan Wu Guosheng Song Zhifang Chai Zhuang Liu Kai Yang | 2016 | Nano Research2016，9，11： | 12 |
| 20 | Value of contrast-enhanced intraoperative ultrasound for cirrhotic patients with hepatocellular carcinoma:A report of 20 cases显示文摘AIM: To assess the clinical value of contrast-enhanced intraoperative ultrasound (CE-IOUS) as a novel tool in partial hepatectomy for cirrhotic patients with hepatocellular carcinoma (HCC). METHODS: From January 2007 to September 2007, a total of 20 consecutive cirrhotic patients with HCC scheduled to undergo partial hepatectomy were studied. Preoperative contrast enhanced computer tomography (CT) and/or magnetic resonance (MR) scans were performed within 1-2 wk before operation. Intraoperative ultrasound (IOUS) and CE-IOUS were carried out after mobilization of the liver. Lesions on precontrast and postcontrast scans were counted and mapped. CE-IOUS was performed with intravenous injection of ultrasound contrast agents SonoVue (Bracco Imaging, Milan, Italy). Arterial, portal and late phases of contrast enhancement were recorded and analyzed. Nodules showing arterial phase hyper-enhancing and/or hypo-enhancing in late parenchymal phase were considered malignant and removed surgically. Ultrasound-guided biopsy and ethanol ablation would be an option if the nodule could not be removed surgically. Newly detected nodules on IOUS showing iso-enhancement in both arterial and late phases were considered benign. These nodules were eitherremoved surgically if they were close to the main lesion or followed by examinations of alpha-fetoprotein (AFP) level and ultrasound and/or CT/MR every 3 mo. RESULTS: IOUS found 41 nodules in total, among which 17 (41.46%) were newly detected compared to preoperative imaging. Thirty-three nodules were diagnosed malignant by CE-IOUS, including one missed by IOUS. The sensitivity and specif icity of CE-IOUS on detecting HCC nodules are 100% (33/33 and 100% (9/9), respectively. Nine nodules were considered benign by CE-IOUS, four was confi rmed at histology and fi ve by follow-up. CE-IOUS changed the surgical strategy in 35% (7/20) of patients and avoid unnecessary intervention in 30% (6/20) of patients. CONCLUSION: CE-IOUS is a useful means to charac-terize the nodules detected by IOUS in cirrhotic liver, to fi nd isoechoic HCC nodules which can not be shown on IOUS and to improve the accuracy of conventional IOUS, thus it can be used as an essential tool in the surgical treatment of cirrhotic patients with HCC. | Qiang Lu Yan Luo Chao-Xin Yuan Yong Zeng Hong Wu Zheng Lei Yao Zhong Yu-Ting Fan Hong-Hao Wang Yang Luo | 2008 | World Journal of Gastroenterology2008，14，25： | 12 |
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