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| 1 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 2 | Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients A multi-institutional report 显示文摘 | Lee CJ Scheiman J Anderson MA | 2008 | J Gastrointest Surg2008，12，2： | 1 |
| 3 | Multi-Slice CT angiography in diagnosing total versus near occlusions of the internal carotid artery :comparison with catheter angiography 显示文摘 | Chen CJ Lee TH Hsu HL | 2004 | Stroke2004，35，1： | 1 |
| 4 | Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta- catenin stabilization 显示文摘 | Wang L Heidt DG Lee CJ | 2009 | Cancer Cell2009，15，3： | 1 |
| 5 | Bile acid exposure up regulates tuberous scl- erosis complex mammalian target of ra- pamycin pathway in Barrett's associated esophageal adeno- car cinoma显示文摘 | Yen CJ Izzo JG Lee DF | 2008 | Cancer Res2008，68，8： | 1 |
| 6 | Radical neck dissection: elective therapeutic and secondary显示文摘 | Lee JG Krause CJ | 1975 | J Arch Otolaryngology1975，101，： | 1 |
| 7 | A new portal for gynecologic laparoscopy显示文摘 | Lee CL Jain S Wang CJ | 2001 | J Am Assoc Gynecol Laparosc2001，18，1： | 1 |
| 8 | Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study 显示文摘 | Lee AJ Evans CJ Allan PL | 2003 | J Clin Epidemiol2003，56，： | 1 |
| 9 | Prevalence of occult HBV infection among subjects with normal serum ALT levels in Korea 显示文摘 | Kim SM Lee KS Park CJ | 2007 | J Infect2007，54，2： | 1 |
| 10 | Cognitive effects of hormone therapy in men with prostate cancer:a review显示文摘 | Nelson CJ Lee JS Gamboa MC | 2008 | Cancer2008，113，： | 1 |
| 11 | Risk factors for adjacent segment disease after lumbar fusion显示文摘 | Lee CS Hwang CJ Lee SW | 2009 | Eur Spine J2009，18，11： | 1 |
| 12 | Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)显示文摘 | Taylor PA Ehrhardt MJ Lees CJ | | 0，，： | 1 |
| 13 | Ultrastructure and morphology ofbiofilms on thermoplastic orthodontic appliances in 'fast' and 'slow'plaque formers显示文摘 | Low B Lee W Seneviratne CJ | 2011 | Eur J Orthod2011，33，5： | 1 |
| 14 | The impact factors on the cost and length of stay among acute ischemic stroke 显示文摘 | Huang YC Hu CJ Lee TH | 2013 | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2013，22，7： | 1 |
| 15 | Total pelvic mesh repair: a ten --year experience显示文摘 | Sullivan ES Longaker CJ Lee PY | 2001 | Dis Colon Rectun2001，44，6： | 1 |
| 16 | Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta - catenin stabilization显示文摘 | Wang L Heidt DG Lee CJ | 2009 | Cancer Cell2009，15，3： | 1 |
| 17 | Evolving options in the management of esophageal pertoration 显示文摘 | Brinster CJ Singhal S Lee L | 2004 | Ann Thorac Surg2004，77，3： | 1 |
| 18 | The infusion of ex vivo activated and expanded CD4+CD25+immune regulatory cells inhibits graft-versus-host disease lethality显示文摘 | Taylor PA Lees CJ Blazar BR | 2002 | Blood2002，99，10： | 1 |
| 19 | Expression of the bile salt export pump is maintained after chronic cholestasis in the rat 显示文摘 | Lee JM Trauner M Soroka CJ | 2000 | Gastroenterology2000，118，1： | 1 |
| 20 | Immune response of neonate to pneumococcal polysaccharide protein conjugate显示文摘 | LIN T LEE CJ | 1982 | Immunology1982，46，2： | 1 |
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