|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 2 | The TRH neuron : a hypothalamic integrator of energy metabolism显示文摘 | Lechan RM Fekete C | 2006 | Proq Brain Res2006，153，： | 1 |
| 3 | Intracerebroventricular administration of ct-melanocyte stimulating hormone in- creases phosphorylation of CREB in TRH-and CRH-pro- ducing neurons of the hypothalamic paraventricular nu- cleus 显示文摘 | Sarkar S Legradi G Lechan R M | 2002 | Brain Research2002，945，1： | 1 |
| 4 | Immunoreactive inter- leukin-1 beta localization in the rat forebrain显示文摘 | Lechan RM Toni R Clark BD | 1990 | Brain Res1990，514，1： | 1 |
| 5 | lmmunoreactice interleukinq1 beta localization in the rat forebrain 显示文摘 | Toni R Clark BD | 1990 | Brain Res1990，514，： | 1 |
| 6 | Changes in adrenal status affect hypothalamic thyrotropin-releasing hormone gene expression in parallel with corticotropin-releasing hormone显示文摘 | Kakucksa I Qi Y Lechan R | 1995 | Endocrinology1995，136，7： | 1 |
| 7 | Immunoreactive interleukin-1 localization in the rat显示文摘 | Toni R Clark B D | 1990 | Brain Res1990，514，1： | 1 |
| 8 | Immunoreactive interleukin-1 beta localization in the rat forebrain 显示文摘 | Lechan RM Toni R Clark BD | 1990 | Brain Res1990，514，1： | 1 |
| 9 | Neuroendocrine regulation of thyrotropin-releasing hormone (TRH) in the tuberoinfundibular system 显示文摘 | Toni R Lechan RM | 1993 | J Endoerinol Invest1993，16，： | 1 |
| 10 | Prima ry hepatocytes: current understanding of the regu lation of metabolic enzymes and transporter pro- teins, and pharmaceutical practice for the use of hepatoeytes in metaboiism, enzyme induction, transporter, clearance, and hepatotoxicity studies 显示文摘 | Hewitt NJ Lechan MJ Houston JB | 2007 | Drug MetabRev2007，39，1： | 1 |
| 11 | The dilemma of the nonthyroidal illness syndrome显示文摘 | LECHAN R M | 2008 | Acta Biomed2008，79，3： | 1 |
| 12 | Composite pheochromocytoma/ganglioneuroma of the adrenal gland associated with multiple endocrine neoplasia 2A:Case report with immunohistochemical analysis显示文摘 | Brady S Lechan RM Schwaitzberg SD | | 0，，： | 1 |
| 13 | Immunoreactive interleukin-1β localization in the rat显示文摘 | Lechan RM Toni R Clark BD | 1990 | Brain RES1990，514，1： | 1 |
| 14 | Immunoreactive interleukin-1 beta localization in the rat forebrain显示文摘 | Lechan RM Toni R Clark BD | 1990 | Brain Res1990，514，1： | 1 |
| 15 | The TRH neuron: a hypothalamic integrator of energy metabolism 显示文摘 | Lechan RM Fekete C | 2006 | Prog Brain Res2006，15，3： | 1 |
| 16 | The dilemma of the nonthyroidal illnesssyndrome显示文摘 | Lechan RM | 2008 | Acta Biomed2008，79，3： | 1 |
| 17 | Ontogeny of thyrotropin-releasing hormone and histidyl proline diketopiperazine in the rat central nervous system and pancreas显示文摘 | Lamberton R P Lechan R M Jackson I M | 1984 | Endocrinology1984，115，6： | 1 |
| 18 | Changes in adrenal status affect hypothalamic thyrotropin-releasing hormone gene expression in parallel with corticotropin-releasing hormone显示文摘 | Kakucska I Qi Y Lechan RM | 1995 | Endocrinology1995，136，7： | 1 |
| 19 | Immunoreactiveinterleukin-I localization in the rat显示文摘 | Lechan RM Toni R Clark BD | | 0，，01： | 1 |
| 20 | The TRH neuron: a hypothalamic integrator of energy metabolism 显示文摘 | Lechan R M Fekete C | 2006 | Prog Brain Res2006，153，209： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员