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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | The phylogeny and systematics of the endemic Ethiopian Lophuromys flavopunctatus species complex based upon random amplified polymorphic DNA (RAPD) analysis显示文摘 | Lavrenchenko L A Potapov S G Lebedev V S | 2001 | Bioch Syst Ecol2001，29，11： | 1 |
| 3 | Cold Crucible Inductive Melting Technology Application to Vitrification and Ceramization of High Level and Actinide Wastes显示文摘 | Stefanovsky S V Lebedev V V Ptashkin A G | 2010 | Advances in Science and Technology2010，73，： | 1 |
| 4 | Broadband neutron spin-flippers on magnetized foils显示文摘 | LEBEDEV V T TRK G | 2002 | Nuclear Instruments and Methods in Physics Research A2002，195，： | 1 |
| 5 | A differentially pumped electrostatic lens system for photoemission studies in the millibar range 显示文摘 | Ogletree D F Bluhm H Lebedev G | 2002 | Review of Scientific Instruments2002，73，： | 1 |
| 6 | GC- MS comparison of the behavior of chlorine and sodium hy- pochlorite towards organic compounds dissolved in water 显示文摘 | Lebedev A T Shaydullina G M Sinikova N A | 2004 | Water Res2004，38，17： | 1 |
| 7 | Epitaxial growth of AlN and GaN on Si(111)by plasmaassisted molecular beam epitaxy显示文摘 | Schenk H P D Kipshidze G D Lebedev V B | 1999 | J Cryst Grow1999，，： | 1 |
| 8 | OXYS rats as a model of senile cataract显示文摘 | KOLOSOVA N G LEBEDEV P A AIDAGULOVA S V | 2003 | Bull Exp Biol Med2003，136，41： | 1 |
| 9 | High efficiency separators with string-type demisters显示文摘 | Lebedev Y N Chekmenev V G Vybornov V G | 1988 | Chemistry and Technology of Fuels and Oils1988，24，1： | 1 |
| 10 | Upper mantle beneath Southeast Asia from S velocity tomography显示文摘 | Lebedev S Nolet G | 2003 | Journal of Geophysical Research2003，108，1： | 1 |
| 11 | Structure and microstructure of LaI _xCaxMnO3_s thin films prepared by pulsed laser deposition 显示文摘 | Lebedev O I Tendeloo G Van Amelinckx S | 1998 | Phys Rev B1998，58，12： | 1 |
| 12 | Classification and control of the origin of photoluminescence from Si nanocrystals显示文摘 | Godefroo S Hayne M Jivanescu M Stesmans A Zacharias M Lebedev O I Van Yendeloo G Moshchalkov V V | | 0，，03： | 1 |
| 13 | The past, present, and future of Z pinches显示文摘 | Haines M G Lebedev S V Chittenden J P | 2000 | Physics of Plasma2000，7，5： | 1 |
| 14 | Seasonal variability of physical-mechanlcal characteristics of sea ice显示文摘 | GAVRILO V P LEBEDEV G A FEDOTOV V I | 1991 | International Journal of Offshore and Polar Engineering1991，1，1： | 1 |
| 15 | Adhesion wear mechanisms under dry friction of titanium alloys in vacuum 显示文摘 | LEBEDEVAL PRESNYAKOVA G N | 1991 | Wear1991，148，： | 1 |
| 16 | Genetic divergence and phylogeny of the Salmoninae based on allozyme data显示文摘 | Osinov A G Lebedev V S | 2000 | Fish Biol2000，57，： | 1 |
| 17 | Pd-In2O3 interaction due to reduction in hydrogen:consequences for methanol steam reforming显示文摘 | Lorenz H Turner S Lebedev O I van Tendeloo G Kl(o)tzer B Rameshan C Pfaller K Penner S | | 0，，： | 1 |
| 18 | Efficient anisotropic refinement of macromolecular structures using FFT显示文摘 | MURSHUDOV G N VAGINA A LEBEDEV A et ol | 1999 | Acta Crystallographica Section D: Biological Crystallography1999，55，1： | 1 |
| 19 | High power CO2-laser radiation conversion with AgGaSe2 and AgGa1-xInxSe2 crystals显示文摘 | Apollonov V V Lebedev S P Komandin G A | 1999 | Laser Phys1999，9，6： | 1 |
| 20 | Chemically modified short interfering hybrids(siHYBRIDS) : Nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2 显示文摘 | HOGREFE R I LEBEDEV A V ZON G | 2006 | Nucleosides Nucleotides Nucleic Acids2006，25，8： | 1 |
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