|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Chapter 24 Agent-based Computational Finance显示文摘 | Blake LeBaron | 2006 | Handbook of Computational Economics2006，，： | 2 |
| 3 | Nonlinear dynamics and stock retuma显示文摘 | SCHEKMAN J A LEBARON B | 1989 | Journal of Business1989，62，： | 2 |
| 4 | Nonlinear dynamics and stock returns显示文摘 | SCHEINKMAN J A LEBARON B | 1989 | The Journal of Business1989，62，3： | 1 |
| 5 | Polymer-layered silicate nanocomposites:an overview显示文摘 | Peter C Lebaron Zhen Wang Thomas J Pinnavaia | 1999 | Applied Clay Science1999，15，： | 1 |
| 6 | Variations ofbacterial-specific activity with cell size and nucleic acidcontent assessed by flow cytometry 显示文摘 | Lebaron P Servais P Baudoux AC | 2002 | Aquatic MicrobialEcology2002，28，2： | 1 |
| 7 | Time series properties of an artificial stock market 显示文摘 | LeBaron B | 1999 | Journal of Economic Dynamics & Control1999，23，910： | 1 |
| 8 | β-D-glucuronidase activity assay to assess viable Escherichia coli abundance in freshwaters 显示文摘 | Garcia-Armisen T Lebaron P Servais P | 2005 | Lett Appl Microbiol2005，40，： | 1 |
| 9 | Time Series Properties of an Artificial Stock Market显示文摘 | ARTHUR W B PALMER R | 1999 | Journal of Economic Dynamic & Control1999，23，： | 1 |
| 10 | Polymer-layered silicate nanocomposites: An overview显示文摘 | LeBaron Peter C Wang Zhen Pinnavaia Thomas J | 1999 | Appl Clay Sci1999，15，12： | 1 |
| 11 | Polymer-layered silicate nanocomposites:an overview显示文摘 | LeBaron P C Wang Z Pirnavaia T J | 1999 | Applied Clay Science1999，15，1： | 1 |
| 12 | Extracellular matrix cell adhesion peptides: functional applications in orthopedic materials 显示文摘 | Lebaron R G Athanasiou K A | 2000 | Tissue Engi2000，6，： | 1 |
| 13 | Polymer-layered silicate nanocomposites: An overview显示文摘 | LeBaron P C Wang Z Pinnavaia T J | 1999 | Applied Clay Science1999，15，12： | 1 |
| 14 | Inhibition of transeription factor Stat5 induces cell death of human prostate cancer cells显示文摘 | Ahonen TJ Xie jw Lebaron MJ | 2003 | J Biol Chem2003，278，27： | 1 |
| 15 | Assessment of acute pain and anxiety in children and adolescents by self - reports, observer reports, and a behavior checklist 显示文摘 | LeBaron S Zeltzer L | 1954 | J Consult Clin Psychol1954，52，5： | 1 |
| 16 | Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells显示文摘 | Ahonen TJ Xie JW Lebaron MJ | 2003 | Biol Chem2003，278，27： | 1 |
| 17 | Simple Technical Trading Rules and the Stochastic Properties of Stock Returns 显示文摘 | Brock W LJ LeBaron B | 1992 | Joumal of Finance1992，47，5： | 1 |
| 18 | Human prolactin receptorsare insensitive to mouse prolactin:implications for xenotransplant mod-eling of human breast cancer in mice显示文摘 | Utama FE LeBaron MJ Neilson LM | 2006 | Endocrinol2006，188，3： | 1 |
| 19 | Epigenetics and chemicalsafety assessment 显示文摘 | LeBaron MJ Rasoulpour RJ Klapacz J | 2010 | Mutat Res2010，705，2： | 1 |
| 20 | Handover patterns : an ob- servational study of critical care physicians 显示文摘 | Ilan R Lebaron CD Christianson MK | 2012 | BMC Health Serv Res2012，12，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员