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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 3 | A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors显示文摘 | Voorhoeve PM le Sage C Schrier M | 2006 | Cell2006，124，6： | 1 |
| 4 | Prediction of pulmonary embolism in the emergency department; the revised Geneva score显示文摘 | Le Cal G Righini M Roy PM | 2006 | Ann Inern Med2006，144，3： | 1 |
| 5 | A genetic screenimplicates miRNA-372 and miRNA-373 as oncogenes in testiculargerm cell tumors显示文摘 | Voorhoeve PM le Sage C Schrier M | 2006 | Cell2006，124，： | 1 |
| 6 | Subjective reactions to intervention with artificial interferences in subjects with and without a history of temporomandibular disorders显示文摘 | Le Bell Y Niemi PM J(a)ms(a) T | 2006 | Acta Odontol Scand2006，64，1： | 1 |
| 7 | C-reactive protein collaborates with plasma lectins to boost immune response against bacteria显示文摘 | Ng PM Le Saux A Lee CM | 2007 | EMBO J2007，26，14： | 1 |
| 8 | Totem:a fault-tolerant multicast group communication system显示文摘 | MOSER LE MELLIAR-SMITH PM AGARWAL DA | 1996 | Communications of the ACM1996，39，4： | 1 |
| 9 | Physiological versus standard sex steroid replacement in young women with premature ovarian failure:effects on bone mass acquisition and turnover 显示文摘 | Crofton PM Evans N Bath LE | 2010 | Clin Endocrinol (Oxf)2010，73，6： | 1 |
| 10 | Iodine nutrition during pregnancy in Toronto, Canada 显示文摘 | Katz PM Leung AM Braverman LE | 2013 | EndocrPract2013，19，2： | 1 |
| 11 | Cellular uptake of lead is activated by deple- tion of intraeellular calcium stores 显示文摘 | Kerper LE Hinkle PM | 1997 | J Biol Chem1997，272，13： | 1 |
| 12 | A study of pain threshold in diabetics with neuropathic foot lesions显示文摘 | Le Quesne PM Fowler CJ | 1986 | J Neurol Neurosurg Psychiatr1986，49，10： | 1 |
| 13 | Prediction of pulmonary embolism in the emergency department: the revised geneva score显示文摘 | Le Gal G Righini M Roy PM | 2006 | Ann Intern Med2006，144，3： | 1 |
| 14 | A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors显示文摘 | Voorhoeve PM le Sage C Schrier M | 2007 | Adv Exp Med Biol2007，604，： | 1 |
| 15 | Methylation profiling of benign and malignant breast lesions and its application to cytopathology显示文摘 | Pu RT Laitala LE Alli PM | 2003 | Mod Pathol2003，16，11： | 1 |
| 16 | Psychological factors and responses to artificial interferences in subjects with and without a history of temporomandibular disorders显示文摘 | Niemi PM Le Bell Y Kylm(a)l(a) M | 2006 | Acta Odontol Scand2006，64，5： | 1 |
| 17 | Translating clinical trials into meaningful outcomes 显示文摘 | LoRusso PM Schnipper LE Stewart DJ | 2010 | Clin Cancer Res2010，16，24： | 1 |
| 18 | A gene for hereditary multiple exostoses maps to chromosome 19p显示文摘 | Le Merrer M Legeai-Mallet L Jeannin PM | 1994 | Hum Mol Genet1994，3，： | 1 |
| 19 | Progress in the development of Lactococcus lactis as a recombinant mucosal vaccine delivery system显示文摘 | Le Page RW Wells JM | 1995 | Folia Microbiol (Praha)1995，40，： | 1 |
| 20 | Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men显示文摘 | Rohde LE Hennekens CH Ridker PM | 1999 | Am J Cardiol1999，84，9： | 1 |
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