维普中文期刊产品整合服务
607篇 您的检索式:作者名="Le JM"
    题名 作者 年代 出处 被引量
1Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZGururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE 2010中国神经肿瘤杂志2010,8,2:7
2胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) 2018神经损伤与功能重建2018,13,9:2
3Delayed neuro trophin treatment from fllowing deafness rescues spiral gan glion cells from death and promotes regrowth of auditory nerve peripheral proeesses effects of brainderived neurotro phie factor and fibroblast growth factor显示文摘Miller JM Le Prell CG Prieskorn DM 2007J Neurosci Res2007,85,:1
4Decompressive craniectomy for management of traumatic brain injury:an update显示文摘Bohman LE Schuster JM 2013Curr Neurol Neurosci Rep2013,13,11:1
5CD4+ T cells depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract显示文摘Brench JM Schacker TW Ruff LE 2004J Exp Med2004,200,:1
6Steroid treatment and osteonecrosis:Commeut on the article by yamamoto et al显示文摘Le Parc JM Paolaggi JB 1998Arthritis Rheum1998,41,9:1
7Electrical alternans and vulnerability to ventricular arrhythmias显示文摘 JACKSON LE SMITH JM 1994N Engl J Med1994,330,4:1
8Expermental spinal fusion with recombinant human bone morphogenetie protein - 2 without decortieaion of osseous elements 显示文摘Sandhu HS Kanim LE Toth JM 1997Spine1997,22,:1
9Treatment of trigeminal neuralgia with microvascular decompression显示文摘Sindou M Leston JM Le Guerinel C 2009Neurochirurgie2009,55,2:1
10Intrathecal bupivacaine in humans:influence of volume and baricity of solutions显示文摘 Renaud G Le Corre P 1999Anesthesiology1999,91,5:1
11An ex vivo biomechanieal evaluation of a hydroxyapatite cement for use with vertebroplasty显示文摘Belkoff SM Mathis JM Jasper LE 2001Spine2001,26,14:1
12Up-regulation of laminin B2 gene expression in dorsal root ganglion neurons and nonneuronal cells during sciatic nerve regeneration显示文摘Le Beau JM Liuzzi FJ Vinik AI 1995Exp Neurol1995,134,:1
13Development and valida- tion of a measure of emotional intelligence 显示文摘Schutte NS Malouff JM Hall LE 1998Pers Individ Dif1998,25,2:1
14The biomechanies of vertebroplasty:the effect of cement volume on mechanical behavior显示文摘Belkoff SM Mathis JM Jasper LE 0,,:1
15Rank-l and rank:T cells,bone loss,and mammalian evolution显示文摘Theill LE Boyle WJ Penninger JM 0,,0:1
16Nutritional of the insulin-like growth factors显示文摘Thissen JP Ketelslegers JM Underwood LE 1994Endocr Rev1994,15,:1
17Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes:Effects of brain-derived neurotrophic factor and fibroblast growth factor显示文摘Miller JM Le Prell CG Prieskorn DM 2007J Neurosci Res2007,85,9:1
18Student burnoutand engagement: a test of the conservation of resourcestheory显示文摘Alarcon GM Edwards JM Menke LE 2011J Psychol2011,145,3:1
19Dieleman, Antipsychotics and the Risk of Sudden Cardiac Death 显示文摘Sabine M Straus JM Gyse'le S 2004Arch Intern Med2004,164,12:1
20Effect of a combination of ethinylestradiol 30 microg and drospirenone 3 mg on tolerance, cycle control, general well-being and fluid-related symptoms in women with premenstrual disorders requesting contraception 显示文摘BORGES LE ANDRADE RP ALDRIGHI JM 2006Contraception2006,74,6:1
返回顶部 每页显示:
共31页 首页 上一页 第1页 下一页 末页 /31 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费