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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Comparison of the liver stiffness measurement by transient elastography with the liver biopsy显示文摘AIM: To compare the liver stiffness (LS) measurement by transient elastography (TE) to the liver biopsy (LB)-considered the 'gold standard' in the evaluation of patients with chronic hepatitis C. METHODS: During a period of 12 mo, we evaluated 199 consecutive patients with chronic hepatitis due to hepatitis C virus (HCV), in which LB and LS assessments (by means of TE) were performed during the same session. RESULTS: Out of 199 patients, a valid measurement of the LS could not be obtained in 8. The mean value of LS in the cohort of 191 valid measurements was 8.45 ± 4.96 kPa, ranging from 2.3 to 38 kPa. The mean value of LS in patients with signifi cant fi brosis at biopsy (161 patients with F ≥ 2 according to Metavir) was 9.02 ± 5.15 kPa, significantly higher than in patients with no or mild fi brosis (30 patients with F < 2 Metavir): 5.39 ± 1.81 kPa (P < 0.0001). For a cut- off value of 6.8 kPa, the LS had a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6% and a specificity of 93.3% for the presence of signifi cant fi brosis (at least F2 Metavir), with a diagnostic performance of 77.3% (AUROC 0.773). Using this cut-off value, we reached the best discrimination between absence of fibrosis/ mild fibrosis (F < 2 Metavir) and the presence ofmoderate to severe fi brosis (F ≥ 2 Metavir). CONCLUSION: In patients with chronic hepatitis due to HCV, a cut-off value of 6.8 kPa measured by TE can differentiate between significant fibrosis and absent or mild fi brosis, with a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6%, a specificity of 93.3%, and a diagnostic performance of 77.3%. | Ioan Sporea Roxana ■irli Alexandra Deleanu Adriana Tudora Manuela Curescu Marioara Cornianu Daniela Lazǎr | 2008 | World Journal of Gastroenterology2008，14，42： | 20 |
| 3 | 影响土壤镉吸持和解吸的因子显示文摘研究了土壤的pH、离子浓度(0.01mol/L、0.05mol/L、0.1mol/L)、阴(阳)离子种类(NO_3^-、Cl^-、OAc^-、SO_4^(2-)、HPO_4^-及Zn和Pb)及石灰和葡萄糖对土壤镉吸持及其解吸的影响。 | Toader Lazǎr 邵孝侯 邢光熹 | 1992 | 土壤1992，24，3： | 13 |
| 4 | Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species显示文摘Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(C.benghalensis) and Coffea liberica compared to Coffea arabica(C.arabica).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of C.benghalensis and Coffea liberica were quantified and compared to C.arabica.Enhanced chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were used.Results:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of C.benghalensis showed much higher DPPH scavenging potential than was seen in the ECL assay.The immature pericarp of C.benghalensis expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of C.arabica.The immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic contents.Conclusions:The obtained data highlight the potential role of C.benghalensis as a new source of natural antioxidants and polyphenols compared to C.arabica. | va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 3 |
| 5 | PRL-1, a unique nuclear protein phosphatase, affects cell growth 显示文摘 | Diamond RH Cressman DE Laz TM | 1994 | Mol Cell Biol1994，14，6： | 1 |
| 6 | Probabilistic molec- ular dynamics evaluation of the stress-strain behavior of poly- ethylene显示文摘 | Stowe J Q Predeeki P K Laz P J | 2009 | ActaMaterialia2009，57，12： | 1 |
| 7 | Behaviour-driven development of foundational UML components显示文摘 | Laz I Motogna S Parv B | 2010 | Electronic Notes in Theoreti- cal Computer Science2010，264，1： | 1 |
| 8 | A probabilistic total fatigue life model incorporating material inhomogeneities, stress level, and fracturs mechanics显示文摘 | Laz P J Craig B A Hilberry B M | 2001 | Int J Fatigue2001，23，： | 1 |
| 9 | Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus显示文摘 | HOLLOWAY MG CUI Y LAZ EV | 2007 | Endocrinology2007，148，5： | 1 |
| 10 | Fatigue Life Prediction From Inclusion Initiated Cracks显示文摘 | Laz P J Hillberry B M | 1998 | Int J Faugue1998，20，4： | 1 |
| 11 | A HPLC method for the simultaneous determination of seven anthracyclines显示文摘 | BADEA I LAZ'AR L MOJA D | 2005 | J Pharm Biomed Anal2005，39，12： | 1 |
| 12 | New synthesis methods of MgAl2O4 spinel显示文摘 | P(A)CURARIU C LAZ(A)U I ECSEDI Z | 2007 | Journal of the European Ceramic Society2007，27，23： | 1 |
| 13 | Fatigue life prediction from inclusion initiated cracks显示文摘 | Laz P J Hillberry B M | 1998 | Int J Fatigue1998，20，： | 1 |
| 14 | PRL-1,a unique nuclear protein tyrosine phosphatase,affects cell growth显示文摘 | Diamond RH Cressman DE Laz TM | 1994 | Mol Cell Biol1994，14，6： | 1 |
| 15 | A probabilistic total fatigue life model incorporating material inhomogeneities,stress level and fracture mechanics显示文摘 | LAZ P J CRAIG B A HILLBERRY B M | 2001 | International Journal of Fatigue2001，23，： | 1 |
| 16 | Photo induced interaction of antibacterial quinolones with human serum albumin显示文摘 | Franklin Vargas Carlos Rivas Yrene D'laz | 2003 | Toxicology Mechanisms and Methods2003，13，： | 1 |
| 17 | Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients显示文摘 | Jan Václavík David Stejskal Bo?ek La?ňák Marie Lazárová Libor Jedelsky Lenka Kadalová Marie Jano?ová Zdeněk Fry?ák Petr Vl?ek | 2007 | Journal of Hypertension2007，，7： | 1 |
| 18 | Novel anti inflammatory properties of the angiogenesis inhibitor vasostatin显示文摘 | Huegel R Velasco P De la Laz Sierra M | | 0，，1： | 1 |
| 19 | Fatigue life prediction from inelusion initiated cracks 显示文摘 | LAZ P J HILLBERRY B M | 1998 | Fatigue1998，20，1： | 1 |
| 20 | Fatigue life prediction from inclusion initiated cracks 显示文摘 | LAZ P IllLLBERRY B | 1998 | International Journal of Fatigue1998，20，4： | 1 |
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