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| 1 | Observation of ocean current response to 1998 Hurricane Georges in the Gulf of Mexico显示文摘The ocean current response to a hurricane on the shelf-break is examined. The study area is the DeSoto Canyon in the northeast Gulf of Mexico, and the event is the passage of 1998 Hurricane Georges with a maximum wind speed of 49 m/s. The data sets used for analy- sis consist of the mooring data taken by the Field Program of the DeSoto Canyon Eddy Intrusion Study, and simultaneous winds ob- served by NOAA (National Oceanic and Atmospheric Administration) Moored Buoy 42040. Time-depth ocean current energy density images derived from the observed data show that the ocean currents respond almost immediately to the hurricane with important differ- ences on and off the shelf. On the shelf, in the shallow water of 100 m, the disturbance penetrates rapidly downward to the bottom and forms two energy peaks, the major peak is located in the mixed layer and the secondary one in the lower layer. The response dissipates quickly after external forcing disappears. Off the shelf, in the deep water, the major disturbance energy seems to be trapped in the mixed layer with a trailing oscillation; although the disturbance signals may still be observed at the depths of 500 and 1 290 m. Verti- cal dispersion analysis reveals that the near-initial wave packet generated off the shelf consists of two modes. One is a barotropic wave mode characterized by a fast decay rate of velocity amplitude of 0.020 s-1, and the other is baroclinic wave mode characterized by a slow decay rate of 0.006 9 s-1. The band-pass-filtering and empirical function techniques are employed to the frequency analysis. The results indicate that all frequencies shift above the local inertial frequency. On the shelf, the average frequency is 1.04f in the mixed layer, close to the diagnosed frequency of the first baroclinic mode, and the average frequency increases to 1.07f in the thermocline. Off the shelf, all frequencies are a little smaller than the diagnosed frequency of the first mode. The average frequency decreases from 1.035f in the mixed layer to 1.02f in the thermocline, implying a trend for the shift in frequency of the oscillations towards f with the depth. | ZHENG Quanan LAI Ronald J HUANG Nortlen E PAN Jiayi LIU W Timothy | 2006 | Acta Oceanologica Sinica2006，25，1： | 20 |
| 2 | Metal exposure and Alzheimer's pathogenesis.显示文摘 | Liu G Huang W Moir RD Vanderburg CR Lai B Peng Z Tanzi RE Rogers JT Huang X | 2006 | 中国生物学文摘2006，20，9： | 8 |
| 3 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 5 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 6 | Excited - state properties of dioxorhenium(V) generation and reactivity of dioxorhenium(Ⅵ) 显示文摘 | Che C M Chung W C Lai T F | 1989 | Inorg Chem1989，28，： | 1 |
| 7 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
| 8 | High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma : significance of hepatitis virus infection ,age ,p53 ,and beta-catenin mutations显示文摘 | PENG S Y CHEN W J LAI P L | 2004 | Int J Cancer2004，112，1： | 1 |
| 9 | Design and implementation of differential cascode voltage switch with pass-gate (DCVSPG) logic for high-performance digital systems显示文摘 | Hwang W | 1997 | IEEE Journal of Solid-State Circuits1997，32，4： | 1 |
| 10 | Actin, a reliable marker of internal control 显示文摘 | RUAN W J LAI M D | 2007 | Climica Chimica Acta2007，385，12： | 1 |
| 11 | Shipping container logistics and allocation 显示文摘 | ]Lai K K Lam K and Chan W K | 1995 | Operational Research Society1995，46，6： | 1 |
| 12 | Precision modeling of form errors for cylindricity evaluation using genetic algorithms显示文摘 | Lai H Y Jywe W Y Chen C K and Liu C H | 2000 | Precision Engineering2000，24，4： | 1 |
| 13 | A study of system dynamics in just-in-time logistics Lee显示文摘 | Lai W B | 2003 | Journal of Materials Processing Technology2003，，138： | 1 |
| 14 | Pattern formation, synchronization, and outbreak of biodiversity in cyclically competing games显示文摘 | WANG W X NI X LAI Y C | 2011 | Phys Rev E2011，83，01： | 1 |
| 15 | Cortical activa- tion mapping of epileptiform activity derived from interic- tal ECoG spikes显示文摘 | Lai Y van Drongelen W Hecox K | 2007 | Epilepsia2007，48，2： | 1 |
| 16 | Dentification of novel DNA methylation markers in cervical cancer显示文摘 | Lai H C Lin Y W Huang T H M | | 0，，01： | 1 |
| 17 | Onset of catalytic activity gold clusters on titania with appearance of nonmetallic properties显示文摘 | Valden M Lai X Goodman D W | | 0，，： | 1 |
| 18 | Real-time frequency and harmonic evaluation using artificial neural networks显示文摘 | LAI L L TSE C T CHAN W L | 1999 | IEEE Transactions on Power Delivery1999，14，1： | 1 |
| 19 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang W X Yang R Lai Y C Kovanis V Harrison M A F | 2011 | EPL2011，94，48： | 1 |
| 20 | Ventilator-associated pneu- monia in intensive care units in Hubei province, China : a mul- ticentre prospective cohort survey显示文摘 | Xie DS Xiong W Lai RP | 2011 | J Hosp Infect2011，78，4： | 1 |
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