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| 1 | 高血压对肾小球滤过率降低与脑卒中预后相关性的影响显示文摘该研究旨在比较高血压和非高血压患者估算的肾小球滤过率(estimatedglomerularfiltrationrate,eGFR)较低与脑卒中预后的相关性。方法:获取2012和2013年中国脑卒中登记处确定出院脑卒中患者的资料。低eGFR定义为eGFR%60mL/(min·1.73m2)。应用多因素分析评估低eGFR与1年全因死亡率、复发性脑卒中、功能预后不良(改良的Rankin量表评分3~6分)的关系,分析高血压对相关性的影响。 | 刘莉 叶鹏 Wang X Wang Y Patel UD Xie Barnhart H Li Z Li H Wang C Zhao X Liu L Laskowitz DT | 2017 | 中华高血压杂志2017，25，5： | 4 |
| 2 | 成年小鼠中枢神经系统损伤后TT-301可抑制小胶质细胞活化及改善其预后(英文)显示文摘BACKGROUND Microglial inhibition may reduce secondary tissue injury and improve functional outcome following acute brain injury.Utilizing clinically relevant murine models of traumatic brain injury and intracerebral hemorrhage,neuroinflammatory responses and functional | James ML Cantillana V Kernagis DN Dawson HN Klaman LD Laskowitz DT | 2012 | 中华神经外科疾病研究杂志2012，11，2： | 3 |
| 3 | Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore显示文摘Background Emergency medical services(EMS)is a critical link in the chain of stroke survival.We aimed to assess EMS use for stroke in Singapore,identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and treatment.Methods The Singapore Stroke Registry combines nationwide EMS and public hospital data for stroke cases in Singapore.Multivariate regressions with the generalised estimating equations were performed to examine the association between EMS use and timely stroke evaluation and treatment.results Of 3555 acute ischaemic patients with symptom onset within 24 hours admitted to all five public hospitals between 2015 and 2016,68%arrived via EMS.Patients who used EMS were older,were less likely to be female,had higher stroke severity by National Institute of Health Stroke Scale and had a higher prevalence of atrial fibrillation or peripheral arterial disease.Patients transported by EMS were more likely to receive rapid evaluation(door-to imaging time≤25 min 34.3%vs 11.1%,OR=2.74(95%CI 1.40 to 5.38))and were more likely to receive intravenous tissue plasminogen activator(tPA,22.8%vs 4.6%,OR=4.61(95%CI 3.52 to 6.03)).Among patients treated with tPA,patients who arrived via EMS were more likely to receive timely treatment than self-transported patients(door-to needle time≤60 min 52.6%vs 29.4%,OR=2.58(95%CI 1.35 to 4.92)).Conclusions EMS use is associated with timely stroke evaluation and treatment in Singapore.Seamless EMS-Hospital stroke pathways and targeted public campaigns to advocate for appropriate EMS use have the potential to improve acute stroke care. | Hanzhang Xu Ying Xian Fung Peng Woon Janet Prvu Bettger Daniel T Laskowitz Yih Yng Ng Marcus Eng Hock Ong David Bruce Matchar Deidre Anne De Silva | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 4 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 5 | Neuroprotection in subarachnoid hemorrhage 显示文摘 | Laskowitz DT Kolls BJ | 2010 | Stroke2010，41，10： | 1 |
| 6 | Apolipoprotein E isofom-specifie differences in outcome from focai ischemia in transgenic mice 显示文摘 | Sheng H Laskowitz DT Bennett E | 1998 | J Cereb Blood Flow Metab1998，18，4： | 1 |
| 7 | Evolving role of biomarkers in acute ce- rebrovascular disease显示文摘 | Kernagis DN Laskowitz DT | 2012 | Ann Neuro12012，71，3： | 1 |
| 8 | Statins in traumatic brain injury显示文摘 | Wible EF Laskowitz DT | 2010 | Neurotherapeutics2010，7，1： | 1 |
| 9 | Apolipoprotein E isoform-specific differnce in outcome from focal ischemia in transgenie mice显示文摘 | Sheng H Laskowitz DT Bennctt E | 1998 | J Cereb Blood Flow Metab1998，19，： | 1 |
| 10 | Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic显示文摘 | Laskowitz D T Song P Wang H | 2010 | Journal of neurotrauma2010，27，11： | 1 |
| 11 | The syndrome of frontal lobe epilepsy:Characteristics and surgical management显示文摘 | Laskowitz DT Sperling MR French JA | 1995 | Neurology1995，45，： | 1 |
| 12 | A phase 2 multiple ascending dose trial of bapineuzurnab in mild to moderate Alzheimer disease 显示文摘 | Laskowitz DT Kolls BJ | 2010 | Neurolog2010，74，24： | 1 |
| 13 | Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic injuy (BRAIN)study显示文摘 | Laskowitz DT Kasner SE Saver J | 2009 | Stroke2009，40，1： | 1 |
| 14 | Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) Surgery 显示文摘 | Phillips-Bute B Mathew JP Blumenthal JA Grocott HP Laskowitz DT Jones RH | 2006 | Psychosom Med2006，68，： | 1 |
| 15 | The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage显示文摘 | Laskowitz D T Lei B Dawson H N | 2012 | Neurocritical care2012，16，2： | 1 |
| 16 | Clinical application of blood biomarkers in cerebrovascular disease 显示文摘 | E1 Husseini N Laskowitz DT | 2010 | Expert Rev Neu- rother2010，10，2： | 1 |
| 17 | COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury显示文摘 | Laskowitz D T McKenna S E Song P | 2007 | Journal of neurotrauma2007，24，7： | 1 |
| 18 | The syndrome of frontal lobe epilepsy characteristics and surgical management显示文摘 | Sperling MR French JA | 1995 | Neurology1995，45，8： | 1 |
| 19 | Clinical usefulness of a biomarker-based diagnostic test for acute stroke; the biomarker rapid assessment in ischemic injury study显示文摘 | Laskowitz DT Kasner SE Saver J | 2008 | Storke2008，40，： | 1 |
| 20 | Differential cerebral gene expression during ardiopulmonary bypass in the rat: evidence for apoptosis 显示文摘 | Laskowitz DT Bennett ER | 2002 | Anesth Analg2002，94，6： | 1 |
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