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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | Neal J L Larson R I Atkinson T G | 1973 | Plant Soil1973，39，： | 1 |
| 3 | Observed microphysical structure of midlevel, mixed-phase ctouds显示文摘 | Fteishauer R P V E Larson T H Vonder Haar | 2002 | J Atmos Sci2002，59，： | 1 |
| 4 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | NEAL J L LARSON R I ATKINSON T G | 1973 | Plant and Soil1973，39，1： | 1 |
| 5 | Molecular Constitutive Equa-tions for a Class of Branched Polymers: The Pom-PomPolymer显示文摘 | McLeish T Larson R G | 1998 | Journal of Rheology1998，42，1： | 1 |
| 6 | Requirement for 3-Ketoacyl-CoA Thiolase-2 in Peroxisome Development,Fatty Acid Beta-Oxidation and Breakdown of Triacylglycerol in Lipid Bodies of Arabidopsis seedlings显示文摘 | Germain V Rylott E L Larson T R | 2001 | Plant J2001，28，： | 1 |
| 7 | Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly populationfrom Seattle显示文摘 | OLSEN G W CHURCH T R LARSON E B | 2004 | Washington Chemosphere2004，54，： | 1 |
| 8 | Leadership style and the discussion of shared and unshared information in decision- making groups显示文摘 | LARSON J R FOSTER-FISHMAN P G FRANZ T M | 1998 | Personality and Social Psychology Bulletin1998，24，5： | 1 |
| 9 | Conducting backbone in percolating Bethe lattices 显示文摘 | Larson R G Davis H T | 1982 | Journal of Physics C: Solid State Physics1982，15，11： | 1 |
| 10 | In vivo interstitial temperature mapping of the human prostate during cryosurgery with correlation to histopathologic outcomes显示文摘 | LARSON T R RROBERTSON D W CORICAA | 2000 | U- rology2000，55，4： | 1 |
| 11 | Increased prostatic blood flow in response to microwave ghermal treatment:preliminary findings in two patients with benign prostatic hyperplasia显示文摘 | Larson T R Collins J M | 1995 | Urology1995，46，： | 1 |
| 12 | Current treatment options for benign prostatic hyperplasia and their impact on sexual function显示文摘 | Larson T R | 2003 | Urology2003，61，： | 1 |
| 13 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in pa- tients with localized cTlb renal masses 显示文摘 | Weight C J Larson B T Fergany A F Gao T Lane B R Campbell S C | 2010 | J Urol2010，183，： | 1 |
| 14 | Skeletal muscle me- tabolism in endurance athletes with near-infrared speetroscopy显示文摘 | Brizendine J T Ryan T E Larson R D | 2013 | Med Sei Sports Exerc2013，45，5： | 1 |
| 15 | Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors显示文摘 | OJO K K LARSON E T KEYLOUN K R | 2010 | Nat Struct Mol Biol2010，17，5： | 1 |
| 16 | Elective partial nephrectomy in pa tients with clinical Tlb renal tumors is associated with improved overall survivaI显示文摘 | Weight C J Larson B T Gao T Campbell S C Lane B R Kaouk J H | 2010 | Urology2010，76，： | 1 |
| 17 | Elective partial nephrectomy in pa- tients with clinical Tlb renal tumors is associated with improved overall survival显示文摘 | Weight C J Larson B T Gao T Campbell S C Lane B R Kaouk J H | 2010 | Urology2010，76，： | 1 |
| 18 | An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment显示文摘 | Rubio S Larson T R Gonzalez-Guzman M | | 0，，03： | 1 |
| 19 | Feeding value of wet distillers byproducts for finishing ruminants显示文摘 | Larson E M Stock R A Klopfenstein T J | 1993 | Journal of Animal Science1993，71，： | 1 |
| 20 | Corrosion and tuberculation of cast iron 显示文摘 | Larson T E Skold R V | 1957 | Journal American Water Works Association1957，49，10： | 1 |
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