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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 4 | Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to longdistance transfers显示文摘 | Larson D M Duval S Sharkey S W | 2012 | Eur Heart J2012，33，10： | 1 |
| 5 | Elastic waves interacting with buried land mines: A study using the FDTD method显示文摘 | Scott W Jr Larson G D | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，： | 1 |
| 6 | Relationships between spa- tial environmental heterogeneity and plant species diversity on a limestone pavement 显示文摘 | LUNDHOLM J T LARSON D W | 2003 | Ecography2003，26，6： | 1 |
| 7 | Property rights,externalities,and resource degradation:Locating the tragedy显示文摘 | Larson B A Bromley D W | 1990 | Journal of Development Economics1990，33，2： | 1 |
| 8 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M Larson W Linden D | 1997 | Soil Technology1997，10，1： | 1 |
| 9 | Corn growth as affected by soil temperature and mulch显示文摘 | Willis W O Larson W E Kirkham D | 1957 | Agronomy Journal1957，49，： | 1 |
| 10 | In vivo interstitial temperature mapping of the human prostate during cryosurgery with correlation to histopathologic outcomes显示文摘 | LARSON T R RROBERTSON D W CORICAA | 2000 | U- rology2000，55，4： | 1 |
| 11 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M K Larson W E Linden D R | 1997 | Soil Technology1997，10，1： | 1 |
| 12 | Grain boundary segregation in boron added interstitial free steels studied by 3-dimensional atom probe 显示文摘 | Seto K Larson D J Warren P J Smith G D W | 1999 | Set Mater1999，40，： | 1 |
| 13 | Polymeric organosilicon systems, preparation and properties of novel σ-π conjugated polymers with alternating disilanylene and 2,5-diethynylenesilole units in the backbone显示文摘 | Larson R G Mead D W Doi M | 1998 | Macromolecules1998，31，： | 1 |
| 14 | Precise nanometer localization analysis for individual fluorescent probes显示文摘 | Thompson R E Larson D R Webb W W | 2002 | Biophysical Journal2002，82，5： | 1 |
| 15 | Three-dimensional X-ray structural microscopy with submicrometre resolution 显示文摘 | LARSON B C YANG W ICE G E BUDAI J D TISCHLER J Z | 2002 | Nature2002，415，6874： | 1 |
| 16 | Surgeon volume does not predict outcomes in the setting of technical credentialing results from a randomized trial in colon cancer显示文摘 | LARSON D W MARCELLO P W LARACH S W | 2008 | Ann Surg2008，248，5： | 1 |
| 17 | Water-soluble quantum dots for multiphoto fluorescence imaging in vivo显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，： | 1 |
| 18 | Rapid lineage accumulation in a non-adaptive radiation:Phylogenetic analysis of diversification rates in eastern North American woodland salamanders(Plethodontidae:Plethodon)显示文摘 | Kozak K H Weisrock D W Larson A | 2006 | Proceedings of the Royal Society B:Biological Sciences2006，273，： | 1 |
| 19 | Systematic review of economic analyses of healthcareassociated infections显示文摘 | Stone P W Braccia D Larson E | 2005 | Am J Infect Control2005，33，9： | 1 |
| 20 | 查看详情显示文摘 | Larson D W King M L | | 0，，： | 1 |
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