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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 4 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 5 | SimpleScalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Ernst D | 2002 | IEEE Computer2002，35，2： | 1 |
| 6 | Most apparent distortion:full-reference image quality assessment and therole of strategy显示文摘 | Larson E C Chandler D M | 2010 | Journal of Electronic Imaging2010，19，1： | 1 |
| 7 | Tea tree oil 显示文摘 | LARSON D JACOB S E | 2012 | Dermatitis2012，23，1： | 1 |
| 8 | SimpleScalar : an infrastructure for computer system modeling显示文摘 | Austin T Larson E Ernst D | 2002 | Computer2002，35，2： | 1 |
| 9 | Corn growth as affected by soil temperature and mulch显示文摘 | Willis W O Larson W E Kirkham D | 1957 | Agronomy Journal1957，49，： | 1 |
| 10 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 11 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 12 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M K Larson W E Linden D R | 1997 | Soil Technology1997，10，1： | 1 |
| 13 | The effect of remo- ving the true dental follicle on premolar eruption in the dog 显示文摘 | Larson E K Cahill D R Gorski J P | 1994 | Arch Oral Bio11994，39，4： | 1 |
| 14 | Skeletal muscle me- tabolism in endurance athletes with near-infrared speetroscopy显示文摘 | Brizendine J T Ryan T E Larson R D | 2013 | Med Sei Sports Exerc2013，45，5： | 1 |
| 15 | Economic scales for firslngener- ation biomass-gasifier/gas turbine combined cycles fueled from energy plantations显示文摘 | Larson E D Marrison C I | 1997 | Journal of Engineering for Gas Turbines and Power1997，119，2： | 1 |
| 16 | Use of melting point surface coatings for local convection heat transfer measurements in rectangular channel flows with 90-deg turns显示文摘 | Metzger D E Larson D E | 1986 | Journal of Heat Transfer1986，108，1： | 1 |
| 17 | Finite dimensional cosemisimple Hopf algebras in characteristic zero are semisimple显示文摘 | LARSON R G RADFORD D E | 1988 | J Alg1988，117，： | 1 |
| 18 | Precise nanometer localization analysis for individual fluorescent probes显示文摘 | Thompson R E Larson D R Webb W W | 2002 | Biophysical Journal2002，82，5： | 1 |
| 19 | Semisimple cosemisimple Hopf algebras显示文摘 | LARSON R G RADFORD D E | 1988 | Amer J Math1988，110，： | 1 |
| 20 | Three-dimensional X-ray structural microscopy with submicrometre resolution 显示文摘 | LARSON B C YANG W ICE G E BUDAI J D TISCHLER J Z | 2002 | Nature2002，415，6874： | 1 |
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