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| 1 | Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction显示文摘AIM To comprehensively evaluate mitochondrial(dys) function in preclinical models of nonalcoholic steatohepatitis(NASH).METHODS We utilized two readily available mouse models of nonalcoholic fatty liver disease(NAFLD) with or without progressive fibrosis: Lep^(ob)/Lep^(ob)(ob/ob) and FATZO mice on high trans-fat, high fructose and high cholesterol(AMLN) diet. Presence of NASH was assessed using immunohistochemical and pathological techniques, and gene expression profiling. Morphological features of mitochondria were assessed via transmission electron microscopy and immunofluorescence, and function was assessed by measuring oxidative capacity in primary hepatocytes, and respiratory control and proton leak in isolated mitochondria. Oxidative stress was measured by assessing activity and/or expression levels of Nrf1, Sod1, Sod2, catalase and 8-OHdG. RESULTS When challenged with AMLN diet for 12 wk, ob/ob and FATZO mice developed steatohepatitis in the presence of obesity and hyperinsulinemia. NASH development was associated with hepatic mitochondrial abnormalities, similar to those previously observed in humans, including mitochondrial accumulation and increased proton leak. AMLN diet also resulted in increased numbers of fragmented mitochondria in both strains of mice. Despite similar mitochondrial phenotypes, we found that ob/ob mice developed more advanced hepatic fibrosis. Activity of superoxide dismutase(SOD) was increased in ob/ob AMLN mice, whereas FATZO mice displayed increased catalase activity, irrespective of diet. Furthermore, 8-OHd G, a marker of oxidative DNA damage, was significantly increased in ob/ob AMLN mice compared to FATZO AMLN mice. Therefore, antioxidant capacity reflected as the ratio of catalase:SOD activity was similar between FATZO and C57 BL6 J control mice, but significantly perturbed in ob/ob mice. CONCLUSION Oxidative stress, and/or the capacity to compensate for increased oxidative stress, in the setting of mitochondrial dysfunction, is a key factor for development of hepatic injury and fibrosis in these mouse models. | Michelle L Boland Stephanie Oldham Brandon B Boland Sarah Will Jean-Martin Lapointe Silvia Guionaud Christopher J Rhodes James L Trevaskis | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 2 | Sewage pollution in Negril, Jamaica: effects on nutrition and ecology of coral reef macroalgae显示文摘Coral reefs in the Negril Marine Park (NMP), Jamaica, have been increasingly impacted by nutrient pollution and macroalgal blooms following decades of intensive development as a major tourist destination. A baseline survey of DIN and SRP concentrations, C:N:P and stable nitrogen isotope ratios (δ15N) of abundant reef macroalgae on shallow and deep reefs of the NMP in 1998 showed strong P-limitation and evidence of increasing sewage pollution. In 1999, a sewage collection and treatment project began diverting wastewater from the resort and urban areas to a pond system that discharged partially-treated effluent into the South Negril River (SNR). These sewage discharges significantly increased concentrations of NH4+ and SRP (N:P ~13) in the SNR, which flows into Long Bay and around Negril’s 'West End'. Concentrations of SRP, the primary limiting nutrient, were higher on shallow reefs of the West End in 2001 compared to 1998. Stable nitrogen isotope ratios (δ15N) of abundant reef macroalgae on both shallow and deep reefs of the West End in 2002 were significantly higher than baseline values in 1998, indicating an escalating impact of sewage nitrogen pollution over this timeframe. The increased nutrient concentrations and δ15N enrichment of reef macroalgae correlated with blooms of the chlorophyte Chaetomorpha linum in shallow waters of Long Bay and Codium isthmocladum and Caulerpa cupressoides on deep reefs of the West End. Sewage treatment systems adjacent to coral reefs must include nutrient removal to ensure that DIN and SRP concentrations, after dilution, are below the low thresholds noted for these oligotrophic ecosystems. | B. E. LAPOINTE K. THACKER C. HANSON L. GETTEN | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 5 |
| 3 | Chemical and behavioral analysis of the cuticular hydrocarbons from Asian citrus psyllid, Diaphorina citri显示文摘Huanglongbing (HLB ) 是世界范围的柠檬的最破坏的疾病。亚洲柠檬 psyllid, Diaphorina citri Kuwayama (半翅类:Psyllidae ) ,住在韧皮部的细菌的向量, Candidatus Liberibacter asiaticus,它被假定在佛罗里达引起 HLB 柠檬。实验室和领域研究被进行检验男、女的 D 的行为的回答。citri 到他们的表皮的摘录。在 olfactometer 试金,更多的男 D。citri 比空白的控制被吸引到一,五,或 10 个女表皮的摘录等价物单位。结果在清楚或黄的陷井在引诱了, 10 个女表皮的摘录等价物单位吸引了的领域研究被证实成比例地更多的男性与男表皮的摘录或 unbaited 陷井比清楚的陷井引诱了。男、女的 D 的表皮的成分的分析。citri 在他们的表皮的摘录的化学作文揭示了性之间的差别。有从表皮的摘录识别的合成化学药品的实验室生物鉴定显示 dodecanoic 酸比干净空气吸引了更多的男性。与 dodecanoic 酸引诱的陷井没增加 D 的全部的钩子。作为与空白相比,在剂量的陷井测试了的 citri;然而, psyllid 钩子的性比率是在与装载测试的剂量(10.0 mg ) 的最高的诱惑引诱的陷井上偏导的男性。 | Rajinder S. Mann Russell L. Rouseff Jack Smoot Nandikeswara Rao Wendy L. Meyer Stephen L. Lapointe Paul S. Robbins Dong Cha Charles E. Linn Francis X. Webster Siddharth Tiwari Lukasz L. Stelinski | 2013 | Insect Science2013，20，3： | 3 |
| 4 | Modeling the structural dynamic response of overhead transmission lines显示文摘 | G McClure M Lapointe | 2003 | Computers and Structures2003，，8： | 3 |
| 5 | Acromioclavicular and Sternoclavicular Joint Injuries显示文摘 | Peter B. MacDonald Pierre Lapointe | 2008 | Orthopedic Clinics of North America2008，，4： | 2 |
| 6 | Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses显示文摘Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent materials.However,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated circuits.We propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig relations.Supported by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this phenomenon.First,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic circuits.We also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in crystals.Finally,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications. | Jerome Lapointe Jean-Philippe Berube Yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 7 | Comparison of the effects of an angiotensin-converting enzyme inhibitor and a vasopeptidase inhibitor after myocardial infarction in the rat显示文摘 | Lapointe N Blais C Jr Adam A | 2002 | J Am Coll Cardiol2002，39，10： | 2 |
| 8 | Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin - converting enzyme inhibitor, and angiotensin II type I receptor blocker 显示文摘 | Wang CH Leung N Lapointe N | 2003 | Circulation2003，107，14： | 1 |
| 9 | PPARγ inhibition of cyclooxygenase- 2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes 显示文摘 | Mendez M LaPointe MC | 2003 | Hypertension2003，42，4： | 1 |
| 10 | The avian IGF type 1 receptor:cDNA analysis and situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system显示文摘 | Holzenberger M Lapointe F Leibovici M | 1996 | Brain Search Dev- elopmental Brain Research1996，97，1： | 1 |
| 11 | The efects of intrafraction motion on dose homogeneity in abreast phantom with physcal wedges, en- hanced dynamic wedges, and IMRT显示文摘 | Sidhu S Sidhu NP Lapointe C | 2006 | lnt J Radiat Oncol Biol Phys2006，66，1： | 1 |
| 12 | Keratoeysticodontogenictumour: reclassifica- tion of the odontogenickeratocyst from cyst to tumour 显示文摘 | Madras J Lapointe H | 2008 | Tes Dent J2008，125，5： | 1 |
| 13 | Use of beta-blockers in patients with an implantable cardioverter defibrillator显示文摘 | LaPointe NM Stafford JA Pappas PA | | 0，，07： | 1 |
| 14 | Hormonal and spatial regulation of nitric oxide synthases(NOS)(neuronal NOS,inducible NOS,and endothelial NOS)in the oviducts显示文摘 | Lapointe J Roy M St-Pierre I | 2006 | Endocrinology2006，147，12： | 1 |
| 15 | Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin显示文摘 | Vossenaar ER Despres N Lapointe E | 2004 | Arthritis Res Ther2004，6，2： | 1 |
| 16 | An artificial diet for Diaprepes abbreviatus (Coleoptera: Curculionidae) optimized for larval snrvival显示文摘 | Lapointe S L Niedz R P Evens T J | 2010 | FloridaEntomologist2010，93，1： | 1 |
| 17 | The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/-mice显示文摘 | Jérme Lapointe Ying Wang Eve Bigras | 2012 | Cell Biol2012，199，2： | 1 |
| 18 | Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease 显示文摘 | Newby LK LaPointe NM Chen AY | 2006 | Circulation2006，113，2： | 1 |
| 19 | Comparative analysis of the exopolysaccharide biosynthesis gene clusters from four strains of Lactobacillua rhamnosus显示文摘 | PEANT B LAPOINTE G GILBERT C | 2005 | Microbiology2005，151，6： | 1 |
| 20 | Insights into rheumatoid arthritis derived from the Sa immune system 显示文摘 | Menard HA Lapointe E Rahdi MD | 2000 | Arthritis Res2000，2，6： | 1 |
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