|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Laparoscopic resec- tion of rectosigmoid carcinoma:prospective randomised trial显示文摘 | Leung KL Kwok SP Lam SC | 2004 | Lancet2004，363，9416： | 1 |
| 3 | Prevalence of myopia among Hong Kong Chinese schoolchildren: changes over two decades 显示文摘 | Lam CS Lam CH Cheng SC | 2012 | Ophthalmic Physiol Opt2012，32，1： | 1 |
| 4 | Laparoscopic resection of rectosigmoid carcinoma:prospective randomised trial显示文摘 | Leung KL Kwok SP Lam SC | 2004 | Lancet2004，363，9416： | 1 |
| 5 | The impact of in- creasing age on anatomic factors a显示文摘 | Lam RC Lin SC Derubertis B | 2007 | J Vasc Surg2007，45，5： | 1 |
| 6 | Validation and cross-cultural pilot testing of compliance with standard precautions scale: self-administered instrument for clinical nurses显示文摘 | Lam SC | 2014 | Infect Control Hosp Epidemiol2014，35，5： | 1 |
| 7 | Laparoscopic resection of rectosigmoid carcinoma:prospective randomised trial显示文摘 | Leung KL Kwok SP Lam SC | 2004 | Lancet2004，363，9416： | 1 |
| 8 | A randomized,controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC Lam CM Poon RT Ng IO Fan ST Wong J | | 0，，06： | 1 |
| 9 | Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass:a double-blind, randomized, controlled trial显示文摘 | Chen Y Ho SC Lam SSH | 2003 | J Clin Endocrinol Metab2003，88，10： | 1 |
| 10 | A pilot study on tacrolimus treatment in membranous or quiescent lupus nephritis with proteinuria resistant to angiotensin inhibition or blockade显示文摘 | Tse KC Lam MF Tang SC | 2007 | Lupus2007，16，1： | 1 |
| 11 | 'Street ketamine'-associated bladder dysfunction: a report of ten cases 显示文摘 | Chu PS Kwok SC Lam KM | 2007 | Hong Kong Med J2007，13，4： | 1 |
| 12 | Street ketamine'-associ- ated bladder dysfunction :a report of ten cases 显示文摘 | Chu PS Kwok SC Lam KM | 2007 | Hong Kong Med J2007，13，4： | 1 |
| 13 | Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial 显示文摘 | Chen YM Ho SC Lam SS | 2004 | Menopause2004，11，3： | 1 |
| 14 | Retinal thickness in myopic and non-myopic eyes 显示文摘 | Cheng SC Lam CS Yap MK | 2010 | Ophthalmic and Physiological Optics2010，30，6： | 1 |
| 15 | A randomized controlled trial of low-dose recombinant human growth hormone in the treatment of malnourished elderly medical patients显示文摘 | Chu LW Lam ks Tam SC | 2001 | Clin Endocrinol Metal2001，86，5： | 1 |
| 16 | Complete obliteration of intracranial arteriovenous malformation with endovascu- lar cyanoacrylate embolization: initial success and rate of permanent cure 显示文摘 | Yu SC Chan MS Lam JM | 2004 | AJNR Am J Neuroradiol2004，25，7： | 1 |
| 17 | The CCN family of angiogenic regulators:the integrin connection显示文摘 | Lau LF Lam SC | | 0，，01： | 1 |
| 18 | The impact of increasing age on anatomic factors affecting carotid angioplasty and stenting 显示文摘 | Lam RC Lin SC DeRubertis B | 2007 | J Vase Surg2007，45，5： | 1 |
| 19 | Effects of tai chi exercise on pain,balance,muscle strength,and perceived difficulties in physical functioning in older women with osteoarthritis:a randomized clinical trial显示文摘 | Song R Lee EO Lam P Bae SC | | 0，，： | 1 |
| 20 | Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(Ⅱb)beta(3) 显示文摘 | Jedsadayanmata A Chen CC Kireeva ML Lau LF Lam SC | 1999 | J Biol Chem1999，274，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员