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| 1 | Long-term albumin infusion improves survival in patients with cirrhosis and ascites: An unblinded randomized trial显示文摘瞄准:在幸存上调查长期的白朊管理的效果,腹水的复发和另外的复杂并发症的发作。方法:为第一发作的腹水招收的 100 个连续病人被使随机化加人的白朊收到利尿剂第一年和 25 g 里的 25 g/wk 每二 wk 此后(组 1 ) 或利尿剂独自一个(组 2 ) 。没有肝移植,主要端点是幸存。第二等的端点是腹水的复发和另外的复杂并发症的出现。结果:中部的后续是 84 (2-120 ) 瞬间。对待白朊的病人有显著地更大的累积幸存率(Breslow test=7.05, P=0.0078 ) 并且腹水复发的更低的概率(51% 对 94% , P<0.0001 ) 。长期的白朊注入导致了 16 瞬间的幸存的吝啬的增加。结论:在第一发作的腹水以后的长期的白朊管理显著地改进病人的幸存并且减少腹水复发的风险。 | Roberto Giulio Romanelli Giorgio La Villa Giuseppe Barletta Francesco Vizzutti Fabio Lanini Umberto Arena Vieri Boddi Roberto Tarquini Pietro Pantaleo Paolo Gentilini Giacomo Laffi | 2006 | World Journal of Gastroenterology2006，12，9： | 22 |
| 2 | Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model显示文摘 | Cristina Stasi Massimo Rosselli Massimo Bellini Giacomo Laffi Stefano Milani | 2012 | Journal of Gastroenterology2012，，11： | 5 |
| 3 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 3 |
| 4 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 5 | Hepato-splenic lymphoma:a rare entity mimicking acute hepatitis:A case report显示文摘We reported a case of non-Hodgkin's lymphoma where liver involvement was the predominant clinical manifestation. A 27-year old man presented wiht markedly elevated serum aspartate aminotrasferase, alanine aminotransferase and lactate dehydrogenase, reduced prothrombin activity, thrombocytopenic purpura and hepato-splenomegaly without adenopathy. Viral, toxic,autoimmune and metabolic liver diseases were excluded.Bone marrow biopsy showed an intracapillary infiltration of T-lymphocytes with no evidence of lipid storage disease.Because of a progressive spleen enlargement, splenectomy was performed. Histological examination showed lymphomatous intrasinuses invasion of the spleen.Immunohistochemical investigation revealed the T phenotype of the neoplastic cells: CD45+, CD45RO+,CD3+, CD4-, CD8-, TIA1-. About 50 % of the lymphoid cells expressed CD56 antigen. The diagnosis of hepatosplenic T cell lymphoma was done. The patient was treated with chemotherapy, which induced a complete remission. Eighteen months later, he had a first relapse with increased aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase,thrombocytopenic purpura and blast in the peripheral blood.In spite of autologous bone marrow transplantation, he died twenty months after the diagnosis. Even in the absence of a mass lesion or lymphoadenopathy, hepatosplenic Tcell lymphoma should be considered in the differential diagnosis of a patient whose clinical course is atypical for acute hepatic dysfunction. | Federico Perfetto Roberto Tarquini Francesco Mancuso Simonetta di Lollo Silvia Tozzini Giampiero Bellesi Giacomo Laffi | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 6 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 2 |
| 7 | Congenital dacryocystocele:diagnosis and treatment显示文摘 | Cavazza S Laffi GL Lodi L Tassinari G Dall’Olio D | 2008 | Acta Otorhinolaryngol Ital2008，28，6： | 1 |
| 8 | Evidence for a storage pool defect in platclets from cirrhotic patients with defective aggregation 显示文摘 | Laffi G Mana F Gresele P | 1992 | Gastroenterology1992，103，2： | 1 |
| 9 | Long course and prognostic factors of virus-induced cirrhosis of the liver显示文摘 | GENTILINI P LAFFI G LA VILLA G | 1997 | Am J Gastroenterol1997，92，1： | 1 |
| 10 | Long course and prognostic factors of induced cirrhosis of the liver 显示文摘 | Gentilini P Laffi G La Villa G | 1997 | Am J Gastroenterol1997，92，1： | 1 |
| 11 | Liquid chromatographic assay of dimetridazole, ipronidazole, and ronidazole in feeds and premixes显示文摘 | TOLLOMELLI B LAFFI R ROSSATO S | 1992 | Journal of AOAC International1992，75，4： | 1 |
| 12 | Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease-2显示文摘 | LAFFI N B WELLBERG E KWAK H I | 2008 | Mol Cell Biol2008，28，6： | 1 |
| 13 | Long course and prognostic factors of vires induced cirrhosis of the liver 显示文摘 | Gentilini P Laffi G La Villa G | 1997 | Am J Castroenterol1997，92，1： | 1 |
| 14 | Pathogenesis and management of the hepatorenal syndrome 显示文摘 | Laffi G Ville KGL Gertilini P | 1994 | Semin Liver Dis1994，14，1： | 1 |
| 15 | Adiponectin and the cardiovascular system:from risk to disease显示文摘 | Tarquini R Lazzeri C Laffi G | 2007 | Intern Emerg Med2007，2，3： | 1 |
| 16 | Long course and prognostic factors of virus-induced cirrhosis of the liver显示文摘 | GEHTILINI P LAFFI G LA VILLA G | 1997 | Gastroenterol1997，92，： | 1 |
| 17 | Evidence for a storage pool defect in platclets from cirrhotic patients with defective affregation显示文摘 | Laffi G Manna F Gresele P | | 0，，02： | 1 |
| 18 | Adiponectin and the cardio- vascular system:from risk to disease显示文摘 | Tarquini R Lazzeri C Laffi G | 2009 | Intern Emerg Med2009，2，3： | 1 |
| 19 | Evidence for a storage pool defect in platclets from cirrhotic patients with defective aggregation显示文摘 | Laffi G Mana F Gresele P | 1992 | Gastroenterology1992，103，2： | 1 |
| 20 | Efficacy of a dentifricecontaining 5%potassium nitrate and 1500 ppm sodiummonofluorphosphate in a precipitated calcium carbonate base ondentinal hypersensitivity显示文摘 | Schiff T Santos MD Laffi S | 1998 | J Clin Dent1998，9，1： | 1 |
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