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| 1 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Intestinal schistosomiasis in Uganda at high altitude(>1400 m):malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs显示文摘Background:Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely.To assess altitudinal boundaries and at-risk populations,conjoint malacological and epidemiological surveys were undertaken on Mount Elgon(1139 m-3937 m),in Fort Portal crater lakes and in the Rwenzori Mountains(1123 m-4050 m).Methods:Seventy freshwater habitats[Mount Elgon(37),Fort Portal crater lakes(23),Rwenzori Mountains(8)and Lake Albert(2)]were inspected for Biomphalaria species.Water temperature,pH and conductivity were recorded.A parasitological examination of 756 schoolchildren[Mount Elgon(300),Fort Portal crater lakes(456)]by faecal microscopy of duplicate Kato-Katz smears from two consecutive stool samples was bolstered by antigen(urine-CCA dipstick)and antibody(SEA-ELISA)diagnostic assays.Results:Biomphalaria spp.was found up to 1951 m on Mount Elgon and 1567 m in the Fort Portal crater lakes.Although no snail from Mount Elgon shed cercariae,molecular analysis judged 7.1%of snails sampled at altitudes above 1400 m as having DNA of Schistosoma mansoni;in Fort Portal crater lakes three snails shed schistosome cercariae.Prevalence of intestinal schistosomiasis as measured in schoolchildren by Kato-Katz(Mount Elgon=5.3%v.Fort Portal crater lakes=10.7%),CCA urine-dipsticks(18.3%v.34.4%)and SEA-ELISA(42.3%v.63.7%)showed negative associations with increasing altitude with some evidence of infection up to 2000 m.Conclusions:Contrary to expectations,these surveys clearly show that natural transmission of intestinal schistosomiasis occurs above 1400 m,possibly extending up to 2000 m.Using spatial epidemiological predictions,this now places some extra six million people at-risk,denoting an expansion of preventive chemotherapy needs in Uganda. | Michelle CStanton Moses Adriko Moses Arinaitwe Alison Howell Juliet Davies Gillian Allison EJames LaCourse Edridah Muheki Narcis BKabatereine J.Russell Stothard | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 3 | Developmental trajectories of boys' delinquent group membership and facilitation of violent behaviors during adolescence显示文摘 | Lacourse E Nagin D Tremblay R.E Vitaro F.& Claes M | | 0，，： | 1 |
| 4 | Brain motor system function after chronic, complete spinal cord injury显示文摘 | Cramer SC Lastra L Lacourse MG | 2005 | Brain2005，28，12： | 1 |
| 5 | 显示文摘 | LaCourse B C Amarakoon V R W | 1995 | J Am Ceram Soc1995，78，： | 1 |
| 6 | Detection of carbohydrates by capillary electrophoresis with pulsed amperometric detection显示文摘 | OSHEA T J LUNTE S M LACOURSE W R | 1993 | Anal Chem1993，65，7： | 1 |
| 7 | Physical performance measures that predict failer status in community-dwellinglder adults显示文摘 | Macrae PG Lacourse M Moldavon R | 1992 | J Orthop Sports Phys Ther1992，16，3： | 1 |
| 8 | 显示文摘 | LaCourse B C Amarakoon V R W | 1995 | J Am Ceram Soc1995，78，12： | 1 |
| 9 | Experimental survey of the chemical durability of commercial soda-lime-silicate glasses显示文摘 | Christopher W. Sinton William C. LaCourse | 2001 | Materials Research Bulletin2001，，13： | 1 |
| 10 | Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis 显示文摘 | Shinder G A Lacourse M C Minotti S | 2001 | J Biol Chem2001，276，12： | 1 |
| 11 | Variations in K^- Na^+ ion exchange depth in commercial and experimental float glass composition 显示文摘 | Sinton C W Lacourse W C O Connell M J | 1999 | Materials Research Bulletin1999，，34： | 1 |
| 12 | 查看详情显示文摘 | Johnson D C LaCourse W R | | 0，，： | 1 |
| 13 | In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment显示文摘 | Russell M. Morphew Neil MacKintosh Elizabeth H. Hart Mark Prescott E. James LaCourse Peter M. Brophy | 2014 | EuPA Open Proteomics2014，，： | 1 |
| 14 | An eye movement communication-control system for the disabled 显示文摘 | LACOURSE J R HLUDIK J R | 1990 | IEEE Transaction on Biomedical English1990，37，12： | 1 |
| 15 | Parental characteristics associated with childcare use during the first 4years of life:results from a representative cohort of Québec families显示文摘 | Geoffroy MC Séguin JR Lacourse E | 2012 | Can J Public Health2012，103，1： | 1 |
| 16 | Effects of motor imagery training after chronic, complete spinal cord injury显示文摘 | CRAMER S C COHEN M J LACOURSE M G | 2007 | Exp Brain Res2007，177，2： | 1 |
| 17 | A study of high-strength arsenic triselenide glass fibers显示文摘 | W C LaCourse | 1993 | Materials Chemistry and Physic1993，35，1： | 1 |
| 18 | Brain motor system function after chronic,complete spinal cord injury显示文摘 | CRAMER S C LASTRA L LACOURSE M G | 2005 | Brain2005，128，12： | 1 |
| 19 | Evidence inconsistent with a negative influence of T helper 2 cells on protection afforded by a dominant T helper 1 response against Mycobacterium tuberculosis lung infection in mice显示文摘 | Jung YJ LaCourse R Ryan L | 2002 | Infect Immun2002，70，11： | 1 |
| 20 | Brain activation during execution and motor imagery of novel and skilled sequential hand movements显示文摘 | LACOURSE M G ORR E L CRAMER S C | 2005 | Neuroimage2005，27，3： | 1 |
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