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1北祁连早古生代花岗质岩浆作用及构造演化显示文摘北祁连山中段花岗岩锆石SHRIMP定年结果表明,柯柯里岩体的斜长花岗岩和石英闪长岩的年龄分别为512Ma和501 Ma,野马咀和金佛寺花岗岩的年龄分别为508Ma和424Ma。结合区内其它花岗岩体的定年资料,根据花岗岩的岩石地球化学特征及岩体产出的构造位置、区域地质资料等,我们认为,早古生代北祁连洋板块向南俯冲,至少引发了两期花岗质岩浆作用,第一次岩浆作用形成柯柯里斜长花岗岩(512Ma)、野马咀花岗岩(508Ma)和柯柯里石英闪长岩(501 Ma),第二次花岗质岩浆作用形成牛心山花岗岩(477Ma)。由于往南俯冲的板块受到柴达木板块向北俯冲的影响,俯冲受阻,继而俯冲极性发生变化,转向北俯冲,形成了民乐窑沟(463Ma)等花岗岩侵入体。大约440Ma之后,洋盆闭合,柴达木陆块和阿拉善陆块对接碰撞,形成北祁连造山带。由于造山带根部岩石圈发生折沉作用,造山带上不同的块体伸展、滑塌,形成一系列碰撞后花岗岩如金佛寺花岗岩(424Ma)及牛心山岩体的石英闪长岩(435Ma)等。吴才来 徐学义 高前明 李向民 雷敏 郜源红 Ronald B FROST Joseph L WOODEN 2010岩石学报2010,26,4:132
22019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W 2020中华高血压杂志2020,28,3:516
3MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R 2009中国神经肿瘤杂志2009,7,4:56
4南阿尔金茫崖地区花岗岩类锆石SHRIMP U-Pb定年、Lu-Hf同位素特征及岩石成因显示文摘南阿尔金茫崖地区早古生代花岗岩锆石SHRIMP U-Pb定年结果表明,阿克提山花岗岩为264±1Ma,柴水沟花岗岩分别为404±5Ma、406±4Ma,其中的辉绿岩为454±4Ma,常春沟花岗岩分别为411±5Ma、406±3Ma,茫崖镇北石英闪长岩为466±5Ma,阿卡龙山花岗岩为469±6Ma。锆石Lu-Hf同位素分析表明,εHf(t)值大多数为正值,少数继承性锆石为负值,反映了它们的源岩以新生地壳为主,同时,也混有少量的古大陆壳的成分。结合区域地质特征和各岩体的岩石地球化学特征,将南阿尔金茫崖地区早古生代花岗质岩浆活动划分为3期,第一期(465~469Ma)岩石组合为石英闪长岩+花岗闪长岩+花岗岩,具有岛弧火成岩的地球化学属性,其形成可能与洋壳的俯冲作用有关;第二期(404~411Ma)岩石组合为花岗闪长岩+二长花岗岩+正长花岗岩,具有A型花岗岩的地球化学特征,可能与板块碰撞后造山带块体均衡调整有关,第三期(264Ma)岩石组合为石英闪长岩+二长花岗岩+正长花岗岩,也具有I型花岗岩的特征,可能与阿尔金断裂的活动有关。吴才来 郜源红 雷敏 秦海鹏 刘春花 李名则 B Ronald FROST Joseph L WOODEN 2014岩石学报2014,30,8:56
5湖南柿竹园矽卡岩-云英岩型W-Sn-Mo-Bi矿床地质和成矿作用显示文摘柿竹园钨多金属矿床由三个阶段不同成矿作用复合叠加而形成。它们分别与似斑状黑云母花岗岩、等粒黑云母花岗岩和花岗斑岩脉有着成因联系。第一阶段矿化包括含矿块状钙质矽卡岩和含矿退化蚀变岩;第二阶段为云英岩矿化,在空间上叠加于块状矽卡岩及外部的大理岩;第三阶段为与锰质矽卡岩相伴生的铅锌银矿化。本文详细地描述了前两阶段矿化的地质和成矿地球化学特征,并探讨了其成矿过程。在此基础上,建立了柿竹园矿床的多阶段成矿模式。毛景文 李红艳 B Guy L Raimbault 1996矿床地质1996,15,1:44
6Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J 2006中国生物学文摘2006,20,4:31
7Psychosocial determinants of irritable bowel syndrome显示文摘From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal inflammation.Psychological and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome.There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders.In order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been proposed.The psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.Teodora Surdea-Blaga Adriana Bban Dan L Dumitrascu 2012World Journal of Gastroenterology2012,18,7:34
8帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) 2021中国肺癌杂志2021,24,9:34
9最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 2014神经病学与神经康复学杂志2014,11,3:31
10Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable.Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni 2013World Journal of Diabetes2013,4,6:29
11都兰花岗岩锆石SHRIMP定年及柴北缘超高压带花岗岩年代学格架显示文摘柴北缘超高压带东端都兰地区花岗岩锆石SHRIMP U-Pb定年结果表明,野马滩东岩体的年龄为(406.6±3.5)Ma,巴立给哈滩西岩体的年龄分别为(407.3±4.3)和(397±6)Ma,水文站北岩体的年龄分别为(404.5±4.0)和(397.0±3.7)Ma,水文站南岩体的年龄为(380.5±5.0)Ma,察察公麻岩体的年龄分别为(382.5±3.6)和(372.5±2.8)Ma.从年龄上看,这些花岗岩明显地分为两期:早期的为407-397 Ma,晚期的为383-373 Ma.它们主要为准铝质-弱过铝质的石英闪长岩、花岗闪长岩和二长花岗岩.岩石地球化学研究表明,大多数样品为钙碱性系列,少数样品为钙性或碱钙性系列,其中,早期花岗岩的87Sr/86Sr比值(0.7082-0.7110)和模式年龄(T2DM=1.41-1.90 Ga)高于晚期花岗岩(0.7072-0.7091,T2DM=1.07-1.38 Ga),但晚期花岗岩的εNd(t)值(0.6- -3.0)高于早期花岗岩(-3.2- -9.3),表明早期花岗岩可能起源于早中元古代的大陆壳;而晚期花岗岩起源于晚中元古代玄武质地壳.结合区域地质构造特征,可以认为,早期花岗岩的形成与俯冲板块的断离并折返有关,而晚期花岗岩的形成与造山带岩石圈地幔拆沉作用有关.吴才来 郜源红 李兆丽 雷敏 秦海鹏 李名则 刘春花 Ronald B FROST Paul T ROBINSON Joseph L WOODEN 2014中国科学:地球科学2014,44,10:27
12Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X 2010南京医科大学学报(自然科学版)2010,30,8:25
13Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L 2007中国生物学文摘2007,21,11:23
14一项中断时间序列研究与集群随机试验:减少耐药细菌在重症监护室中定植和传播的干预措施显示文摘背景 重症监护室(ICU)是耐药细菌传播的高危科室,在设置标准预防措施时缺乏对"全面筛查和隔离携带或感染耐药细菌者"效果评估的对照研究,本研究评估此干预措施对减少ICU中耐药细菌的定植与传播的效果.曾翠 吴安华 Derde L P G Cooper B S Goossens H 2014中国感染控制杂志2014,13,1:23
15体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B 2020中华高血压杂志2020,28,3:22
16Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells显示文摘:AIM To construct Hsp90 antisense RNAeukaryotic expression vector, transfect it intoSGC7901 and SGC7901/VCR of MDR-type humangastric cancer cell lines, HCC7402 of humanhepatic cancer and Eel09 of human esophagealcancer cell lines, and to study the cell cycledistribution of the gene transected cells andtheir response to chemotherapeutic drugs.METHODS A I .03kb cDNA sequence of Hsp90Pwas obtained from the primary plasmid phHsp90by EcoR 1 and BamH I nuclease digestion andwas cloned to the EcoR 1 and BamH 1 site ofthe pcDNA by T4DNA ligase and an antisenseorientation of Hsp900 expression vector wasconstructed. The constructs were transfectedwith lipofectamine and positive clones wereselected with G418. The expression of RNA wasdetermined with dot blotting and RNaseprotection assay, and the expression of Hsp90protein determined with Western blot. Cell cycledistribution of the transfectants was analyzedwith flow cytometry, and the drug sensitivity ofthe transfectants to adriamycin (ADR ),vincrinstine (VCR ), mitomycin (MMC ) andcyclophosphamide (CTX ) with MTT andintracellular drug concentration of thetransfectants was determined with flowcytometry.RESULTS In EcoR 1 and BamH I restrictionanalysis, the size and the direction of the clonedsequence of Hsp900 remained what had beendesigned and the gene constructs were namedpcDNA-Hsp90. AH^SGC7901, AH^SGC7901/ VCR,AH-HCC7402 and AH-Eel09 cell clones allexpressed Hsp90 anti--sense RNA. Theexpression of Hsp90 was down--regulated in AHSGC7901, AH--SGC7901/ VCR, AH-HCC7402 andAH--Eel09 cell clones. Cell cycle distribution waschanged differently. In AH-SGC7901/ VCR andAH-Ec109 cells, G, phase cells were increased; Sphase and G, phase cells were decreased ascompared with their parental cell lines. In AHSGC7901 cell, G, phase cells were decreased, Qphase cells increased and S phase cells were notchanged, and in AH-HCC7402 cells G,, S and qphase cells remained unchanged as comparedwith their parental cell lines. The sensitivity ofAH--SGC7901, AH--SGC7901/ VCR, AH-HCC7402 andAH-Ec109 to chemotherapeutic drugs, thesensitivity ot AH--SGC7901/ VCR to ADR, VCR,MMC and CTX the sensitivity of AH-HCC7402 toADR and VCR, and the sensitivity of Eel09 toADR, VCR and CTX all increased as comparedwith their parental cell lines. The meanfluorescence intensity of ADR in AH--SGC7901,AH-SGC7901/ VCR, AH--HCC7402 and AH-Ec109was also significantly elevated (P< 0. 05).CONCLUSION Down-regulation of HsP90 couldchange cell cycle distribution and increase thedrug sensitivity of tumor cells.Liu XL Xiao B Yu ZC Guo JC Zhao QC Xu L Shi YQ Fan DM 1999World Journal of Gastroenterology1999,5,3:21
17Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle.WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN 2014Science China Earth Sciences2014,57,12:21
18Treatment of inflammatory bowel disease:A review of medical therapy显示文摘Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. While a cure remains elusive, both can be treated with medications that induce and maintain remission. With the recent advent of therapies that inhibit tumor necrosis factor (TNF) alpha the overlap in medical therapies for UC and CD has become greater. Although 5-ASA agents have been a mainstay in the treatment of both CD and UC, the data for their efficacy in patients with CD, particularly as maintenance therapy, are equivocal. Antibiotics may have a limited role in the treatment of colonic CD. Steroids continue to be the first choice to treat active disease not responsive to other more conservative therapy; non- systemic steroids such as oral and rectal budesonide for ileal and right-sided CD and distal UC respectively are also effective in mild-moderate disease. 6-mercaptopurine (6-MP) and its prodrug azathioprine are steroid-sparing immunomodulators effective in the maintenance of remission of both CD and UC, while methotrexate may be used in both induction and maintenance of CD. Infliximab and adalimumab are anti-TNF agents approved in the US and Europe for the treatment of Crohn's disease, and infliximab is also approved for the treatment of UC.Patricia L Kozuch Stephen B Hanauer 2008World Journal of Gastroenterology2008,14,3:21
19脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patientsOddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD 2011中华神经外科疾病研究杂志2011,10,5:21
20涡轮叶栅前缘上游端壁气膜冷却的流场实验研究显示文摘对前缘上游端壁有单排和双排孔冷却的大尺寸低速涡轮导向叶栅进行了气动测量、热示踪和端壁流场显示 ,在吹风比 1~ 3范围获得了叶栅内的详细流场、冷气的空间分布和端壁上的流动图案。结合先前测得的没有冷却时的流场数据 ,这些结果表明端壁气膜冷却对叶栅流场结构有重大影响 ,吹风比是主宰射流与二次流间相互作用的主要因素 ,双排孔喷射使冷气比单排孔喷射更贴近端壁。低吹风比喷射冷气不能到达压力面并被二次流逐渐卷离端壁 ;中吹风比喷射有效的抑制了二次流的形成 ,并使端壁流线偏向于无粘流流线 ,冷气很均匀的覆盖在端壁上 ;高吹风比喷射可将冷气抛射到压力面上 ,双排孔情况下甚至使二次流反向 。刘高文 刘松龄 许都纯 Lapw orth B L Forest A E 2001航空动力学报2001,16,2:20
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