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| 1 | Phytochemistry,pharmacology,and clinical trials of Morus alba显示文摘The present review is aimed at providing a comprehensive summary on the botany,utility,phytochemistry,pharmacology,and clinical trials of Morus alba(mulberry or sang shu).The mulberry foliage has remained the primary food for silkworms for centuries.Its leaves have also been used as animal feed for livestock and its fruits have been made into a variety of food products.With flavonoids as major constituents,mulberry leaves possess various biological activities,including antioxidant,antimicrobial,skin-whitening,cytotoxic,anti-diabetic,glucosidase inhibition,anti-hyperlipidemic,anti-atherosclerotic,anti-obesity,cardioprotective,and cognitive enhancement activities.Rich in anthocyanins and alkaloids,mulberry fruits have pharmacological properties,such as antioxidant,anti-diabetic,anti-atherosclerotic,anti-obesity,and hepatoprotective activities.The root bark of mulberry,containing flavonoids,alkaloids and stilbenoids,has antimicrobial,skin-whitening,cytotoxic,anti-inflammatory,and anti-hyperlipidemic properties.Other pharmacological properties of M.alba include anti-platelet,anxiolytic,anti-asthmatic,anthelmintic,antidepressant,cardioprotective,and immunomodulatory activities.Clinical trials on the efficiency of M.alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted.The phytochemistry and pharmacology of the different parts of the mulberry tree confer its traditional and current uses as fodder,food,cosmetics,and medicine.Overall,M.alba is a multi-functional plant with promising medicinal properties. | Eric Wei-Chiang CHAN Phui-Yan LYE Siu-Kuin WONG | 2016 | Chinese Journal of Natural Medicines2016，14，1： | 40 |
| 2 | Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence显示文摘AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal HCC.RESULTS We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection. | Ye Xin Koh Hwee Leong Tan Weng Kit Lye Juinn Huar Kam Adrian Kah Heng Chiow Siong San Tan Su Pin Choo Alexander Yaw Fui Chung Brian Kim Poh Goh | 2018 | World Journal of Hepatology2018，10，6： | 10 |
| 3 | Leukocyte driven-decidual angiogenesis in early.pregnancy显示文摘成功的怀孕并且长期,出生后母亲并且后代心脏、脉管、新陈代谢的健康在怀孕期上要求关键母亲的心血管的改编。在怀孕 decidualizing 子宫以内,协调了脉管,免疫学的和 stromal 房间变化发生。可观的注意在开始蜕膜的螺线被给了房间到子宫的生来的杀手(uNK ) 的角色动脉的改变,通常完成由的一个过程在老鼠并且在人中间怀孕期。然而,白血球角色在早得多,区域特定,蜕膜的脉管的改变现在正在被定义。对免疫者的兴趣支持房间的脉管的改变被在象不孕,周期性的自发的流产, preeclampsia (PE ) 和胎儿的生长限制那样的人的 gestational 复杂并发症被报导的脉管的错误驾驶。适当母亲的心血管的回答在怀孕期间保护母亲和他们的孩子免受以后的心血管的疾病风险举起的伤害。对在有 hemochorial 胎座式的种类的怀孕的最早子宫的回答之一是 stromal 细胞 decidualization,它为 angiogenesis 和白血球招募创造唯一的壁龛。在早蜕膜 basalis,将抱发展中的胎盘并且提供主要的血容器支持成熟胎盘的功能的培植地点的方面,白血球极大地被充实并且显示专业化性质。UNK 房间,在早蜕膜 basalis 的最丰富的白血球子集,有 angiogenic 能力并且为正常早蜕膜的 angiogenesis 是必要的。在决定的 uNK 房间和他们的角色的规定母亲并且子孙在怀孕上的心血管的健康并且产后被讨论。 | Patricia DA Lima Jianhong Zhang Caroline Dunk Stephen J Lye B Anne Croy | 2014 | Cellular & Molecular Immunology2014，11，6： | 8 |
| 4 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 5 | Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在 dNK 和 trophoblast 房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的 dNK 房间的功能的特性。尽管 CD56 + 在全部的 CD45 + 白血球之中的 CD16 − dNK 没在这个句号,激活的受体的表示, NKp80 和 NKG2D 上变化,极大地 upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了 extravillous trophoblast 房间的一个显著地更高的数字到 dNK 房间。当 co 有教养时,由第一个三个月 dNK 房间的 NKG2D 表示与 HTR-8 trophoblast 房间线被减少。在第二个三个月, dNK 激活的功能的标记,即, angiogenic 因素生产(例如,脉管的 endothelial 生长因素, interleukin-8, interferon-gamma ) ,尽管有 NKp80 或 NKG2D 表面表示的增加的仍然是的马厩。而且, dNK 房间的 degranulation 能力由 CD107a 估计了在第二个三个月被减少。我们建议在第一个三个月, trophoblast-dNK 相互作用与压制的激活的显型产生 dNK 房间的一张人口。在第二个三个月, trophoblast-dNK 相互作用的损失导致了 dNK 房间功能的抑制,尽管他们的激活的受体表示被增加。我们推测在怀孕期间,二机制操作调制激活受体的 dNK 房间 activation:suppression,这由在第二个三个月联合的 receptor-ligand 的 trophoblasts 和解开在第一个三个月铺平。 | Jianhong Zhang Caroline E Dunk Melissa Kwan Rebecca L Jones Lynda K Harris Sarah Keating Stephen J Lye | 2017 | Cellular & Molecular Immunology2017，14，2： | 4 |
| 6 | Game strategies in network security显示文摘 | Kong-wei Lye Jeannette M. Wing | 2005 | International Journal of Information Security2005，，： | 3 |
| 7 | Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation显示文摘自发的术语劳动在包括 cytokine 生产和白血球渗入的 myometrium 与放大煽动性的事件被联系;然而,调整如此的事件的潜在的机制充分没被理解。我们由成长胎儿假设了子宫的墙的那机械段由子宫的 myocytes 通过各种各样的 cytokines 的版本便于外部白血球溢出进术语 myometrium。人的 myometrial 房间(hTERT-HM ) 受到静态的机械段;调节段的媒介被收集并且分析了使用 48-plex Luminex 试金和 ELISA。人的子宫的 microvascular endothelial 房间(UtMVEC-Myo ) 的房间粘附分子表示上的调节段的媒介的效果被量的聚合酶链反应(qPCR ) 和流动 cytometry 检测;测试 leukocyte-endothelial 相互作用的功能的试金:到 endothelial 房间和象 THP-1 monocytic 房间的移植一样的标记 calcein 的主要人的 neutrophils 的 transendothelial 移植的白血球的粘附被萤光计估计。在 vitro 学习的水流证明机械段(i)直接由 hTERT-HM 细胞导致多重 cytokines 和 chemokines 的分泌物( IL-6 , CXCL8 , CXCL1 ,移植禁止的因素( MIF ), VEGF , G-CSF , IL-12p70 , bFGF 和导出血小板的生长因素子单元 B ( PDGF-bb ), P< ; 0.05 );导致段的 cytokines (ii ) 提高白血球粘附到包围的内皮细胞层子宫的微脉管系统由(iii ) 导致 endothelial 房间粘附分子的表示并且(iv ) 指导外部白血球的 transendothelial 迁居。(vi )抵销 Chemokine 抗体和用途广泛的 chemokine 禁止者堵住白血球移植。我们的数据从子宫的血容器为白血球招募提供机械规定的一个证明给 myometrium,为白血球建议通常认为的机制在劳动和产后的复杂物期间渗透到子宫。 | Yu-Hui Lee | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 8 | Rooftop runoff as a source of contamination: A review显示文摘 | Dennis J. Lye | 2009 | Science of the Total Environment2009，，21： | 2 |
| 9 | The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer显示文摘 | Joanne Smith Lye Mun Tho Naihan Xu David A. Gillespie | 2010 | Advances in Cancer Research2010，，： | 2 |
| 10 | Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis显示文摘 | Martin Briand Jean G. Dumesnil Lyes Kadem Antonio G. Tongue Régis Rieu Damien Garcia Philippe Pibarot | 2005 | Journal of the American College of Cardiology2005，，2： | 2 |
| 11 | Virtual design and testing of protective packaging buffers 显示文摘 | LYE S W LEE S G CHEW B H | 2004 | Computers in Industry2004，54，2： | 1 |
| 12 | Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium显示文摘 | Stevens MY Challis JR Lye SJ | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 13 | microRNA binding sites in Arabidopsis class Ⅲ HD-ZIP mRNAs are required for methylation of the template chromosome显示文摘 | Bao N Lye KW Barton MK | | 0，，： | 1 |
| 14 | Traumatic Brain Injury as a Risk Factor for Alzheimer’s Disease: A Review显示文摘 | Tanya C. Lye E. Arthur Shores | 2000 | Neuropsychology Review2000，，2： | 1 |
| 15 | Void reduction in autoclave processing of ther- moset composites显示文摘 | Boey F Y C Lye S W | 1992 | Composites1992，23，4： | 1 |
| 16 | Risk factors associated with feedintolerance in very low birth weight infants following initiation ofenteral feeds during the first 72 hours of life显示文摘 | Boo NY Soon CC Lye MS | 2000 | J Trop Pediatr2000，46，5： | 1 |
| 17 | Differential expression of activator protein-1transcription factors in pregnant rat myometri-um显示文摘 | Mitchell JA Lye SJ | 2002 | Biol Reprod2002，67，1： | 1 |
| 18 | Risk factom associated with feed intolerance in very low birthweight infants folloing intiation of enteral feeds during the 72 hours of life显示文摘 | Boo NY Soon CC Lye MS | 2000 | J Tropical Pediatr2000，46，5： | 1 |
| 19 | A 5-decade analysis of 13715 carcinoid tumors显示文摘 | Modlin IM Lye KD Kidd M | 2003 | Cancer2003，97，4： | 1 |
| 20 | Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works显示文摘 | Kirk LA TyIer CR Lye CM | 2002 | Environmental Toxicology and Chemistry2002，21，： | 1 |
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