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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | The production of IFN-gamma by IL-12/IL-18 activated macrophages requires STAT4 signaling and is inhibited by IL-4显示文摘 | SCHINDLER H LUTZ M B ROLLINGHOFF M | 2001 | J Immunol2001，166，5： | 1 |
| 4 | Inhaled sevoflurane produces better delayed myocardial pro- tection at 48 versus 24 hour after exposure 显示文摘 | Lutz M Lu H | 2006 | Anesth Analg2006，102，4： | 1 |
| 5 | Dose reduction in subsecond multislice spiral CT examination of children by online tube current modulation显示文摘 | Greess H Lutze J Nomayr A | 2004 | Eur Radiol2004，14，6： | 1 |
| 6 | Larval development of the northern horse mussel, Modiolus modiolus L, including a comparison with the larvae of Mytilus edulis L as an aid in planktonic identification显示文摘 | de Schweinitz E H Lutz R A | 1976 | Biol Bull1976，150，34： | 1 |
| 7 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 8 | Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system显示文摘 | Bayatti N Hermann H Lutz B | 2005 | Endocrinology2005，146，3： | 1 |
| 9 | Scanning silence : mental imagery of complex sounds 显示文摘 | N Bunzeek T Wuestenberg K Lutz H J Heinze L Janeke | 2005 | Neuro- image2005，26，4： | 1 |
| 10 | Structure Refinement of Skutterudite-Type Cobalt Triantimonide, CoSb3 显示文摘 | Schmidt T Kliche G Lutz H D | 1987 | Acta Crystallographica Section C1987，43，： | 1 |
| 11 | Modem trends in polymer bioconjugates design 显示文摘 | Lutz J F Borner H G | 2008 | Progress in Polymer Science2008，33，1： | 1 |
| 12 | Factors affecting the genotoxie potency ranking of natural anthraquinones in mammalian cell culture systems显示文摘 | Mueller SO Lutz WK Stopper H | 1998 | Murat Res1998，414，13： | 1 |
| 13 | Cross-talk of vitamin D and glucocorticoids in hippocampal cells 显示文摘 | Obradovic D Gronemeyer H Lutz B | 2006 | J Neurochem2006，96，2： | 1 |
| 14 | Low temperature conversion of some Brazilian municipal and industrial sludges 显示文摘 | Lutz H Romeiro G A Damasceno R N | 2000 | Bioresource Technology2000，74，： | 1 |
| 15 | Longevity of subitaneous and diapause eggs of Centropages hamatus(Copepoda:Calanoida) from the northern gulf of Mexico显示文摘 | Marcus N H Lutz R V | 1998 | Marine biology1998，131，2： | 1 |
| 16 | Corticotropin-releasing hormone-mediated induction of intracellular signaling path- ways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system 显示文摘 | Bayatti N Hermann H Lutz B | 2005 | Endocrinology2005，146，： | 1 |
| 17 | Verteilung yon Bromid zwischen L6 sungen und chloridischen Salzmineralen显示文摘 | Puchelt H Lutz F Schoch H | 1972 | Natur wissenschaften1972，59，： | 1 |
| 18 | Combining ATRP and 'click' chemistry: A promising platform toward func- tional biocompatible polymers and polymer bioconjugates 显示文摘 | Lutz J F Borner H G Weichenhan K | 2006 | Macromolecules2006，39，19： | 1 |
| 19 | Chiral N-Heterocyclic Carbenes as Stereodirecting Ligands in Asymmetric Catalysis显示文摘 | LUTZ H G STEPHANE B L | 2007 | Topics in Organometal|ic Chemistry2007，21，11： | 1 |
| 20 | Effects of low oxygen concentrations on the hatching and viability of eggs of marine calanoid copepods显示文摘 | Lutz R Marcus N H Chapman J P | 1992 | Marine Biology1992，144，： | 1 |
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