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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | Red imported fire ant impacts on northern bobwhite populations显示文摘 | Allen C R Lutz R S Demarais S | 1995 | Ecol Appl1995，，3： | 1 |
| 4 | Pulse Transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathing显示文摘 | Katz ES Lutz J Black C | 2003 | Pediatr Res2003，53，4： | 1 |
| 5 | Analysis of endogenous cortisol concentrations in the hair of rhesus macaques 显示文摘 | DAVENPORT M D TIEFENBACHER S LUTZ C K | 2006 | General and Comparative Endocrinology2006，147，： | 1 |
| 6 | Absence epilepsy in tottering mutant mice is associated with calcium channel defects显示文摘 | Fletcher F Lutz C O' Sullivan T | 1996 | Cell1996，87，4： | 1 |
| 7 | Multiple sequential insult cause post - pump syndrome显示文摘 | Picone AL Lutz CJ Finck C | 1999 | Ann Thorac Surg1999，67，： | 1 |
| 8 | Transcytosis of lipoprotein lipase across cultured endothelial ceils requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor显示文摘 | OBUNIKE J C LUTZ E P LI Z | 2001 | Journal of Biology Chemistry2001，276，12： | 1 |
| 9 | In vivo evaluation of anodic TiO 2 nanotubes:an experimental study in the pig显示文摘 | von Wilmowsky C Bauer S Lutz R | | 0，，： | 1 |
| 10 | Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R显示文摘 | Opitz CA Litzenburger UM Lutz C | 2009 | Stem Cells2009，27，4： | 1 |
| 11 | Expression of functional kappa opioid receptors on murine dendritic cells显示文摘 | Kirst A Wack C Lutz WK | 2008 | Immunol Lett2008，4，： | 1 |
| 12 | Chloroplast membrane photosta- bility in chiP transgenic tobacco plants deficient in tocopherols 显示文摘 | Havaux M Lutz C Grimm B 2003 | 2003 | Plant Physiology2003，132，1： | 1 |
| 13 | Preparation of segmented copolymers in the presence of an immobilized/soluble hybrid atrp catalyst system显示文摘 | Hong S C Neugebauer D Inoue Y Lutz J-F Matyjaszewski K | 2003 | Macromolecules2003，36，1： | 1 |
| 14 | Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells 显示文摘 | Kleindienst P Wiethe C Lutz MB | 2005 | J Immunol2005，174，7： | 1 |
| 15 | The hydrogen-fueled internal combustion engine:a technical review显示文摘 | White C M Steeper R R Lutz A E | 2006 | InternationalJournal of Hydrogen Energy2006，31，10： | 1 |
| 16 | Preparation of segmented copolymers in the presence of an immobilized/soluble hybrid ATRP catalyst system 显示文摘 | Hong S C Lutz J F Inoue Y | 2003 | Macromolecules2003，36，： | 1 |
| 17 | Analytical studies of silica biomineralization: towards an understanding of silica processing by diatoms显示文摘 | Bnmner E Groger C Lutz K | 2009 | Appl Microbiol Biotechnol2009，84，4： | 1 |
| 18 | The effect of parental expectations on treatment of children with a cough:a report from ASPN显示文摘 | Vinson D C Lutz L J | | 0，，1： | 1 |
| 19 | Setup error and motion during deep inspiration breath-hold breast ra- diotherapy measured with continuous portal imaging 显示文摘 | Lutz C M Poulsen P R Fledelius W | 2016 | Acta Oneol2016，55，2： | 1 |
| 20 | ε - Connections of Abstract Description Systems 显示文摘 | Kutz O Lutz C Woher F | 2004 | Artificial Intelligence2004，156，1： | 1 |
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