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| 1 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 2 | High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes显示文摘Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to date.Ex vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial resolution.Complete tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months post-treatment.Further,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in vivo.Highly effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for AuNRs.These results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy. | Joshua T.Robinson Kevin Welsher Scott M.Tabakman Sarah P.Sherlock Hailiang Wang Richard Luong Hongjie Dai | 2010 | Nano Research2010，3，11： | 20 |
| 3 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 4 | 孕前超重/肥胖与婴儿不良出生结局关系前瞻性队列研究显示文摘目的在队列研究基础之上应用中国妇女体质指数(BMI)标准研究孕前超重/肥胖的妇女与婴儿不良出生结局的关系。方法收集武汉市2011年6月—2013年6月76 709名孕妇的数据,应用logistic回归模型估计妇女孕前BMI和不良出生结局之间的关系。结果与正常体重妇女相比,消瘦妇女顺产的比例较高(OR=1.25, 95%CI=1.20~1.30),超重/肥胖妇女顺产的比例较低(OR=0.52,95%CI=0.48~0.56)。超重/肥胖妇女剖腹产较多(OR=1.94, 95%CI=1.80~2.08),消瘦妇女剖腹产较少(OR=0.80, 95%CI=0.77~0.83)。消瘦妇女阴道手术产比例较高(OR=1.33, 95%CI=1.02~1.73),超重和肥胖妇女阴道手术产较少(OR=0.56, 95%CI=0.32~0.96)。不同BMI组与Apgar评分(1 min)<7及Apgar评分(5 min)<7和新生儿窒息关联没有显著性意义。与正常体重妇女相比,超重/肥胖妇女孩子早产的比例较高(OR=1.29, 95%CI=1.14~1.46),消瘦妇女与早产也呈正相关(OR=1.37,95%CI=1.24~1.51)超重/肥胖妇女与生产巨大儿也有阳性相关(OR=2.36, 95%CI=2.15~2.59);消瘦妇女与生产巨大儿呈负相关(OR=0.51,95%CI=0.46~0.56)。不同BMI组与低出生体重的关联没有显著性差异。结论基于中国成人BMI标准,孕前超重/肥胖对顺产、剖宫产、早产及巨大儿都有显著影响。 | 彭安娜 张斌 李娜 袁丽芬 范丽 Lan Luong 杨少萍 | 2019 | 中国公共卫生2019，35，2： | 13 |
| 5 | Activated carbon derived from rice husk by NaOH activation and its application in supercapacitor显示文摘Four activated carbon(AC) samples prepared from rice husk under different activation temperatures have been characterized by N2adsorption–desorption isotherms, thermogravimetric analysis(TGA–DTA), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). The specific surface area of AC sample reached 2681 m2 g 1under activation temperature of 800 1C. The AC samples were then tested as electrode material; the specific capacitance of the as-prepared activated carbon electrode was found to be 172.3 F g 1using cyclic voltammetry at a scan rate of 5 mV s 1and 198.4 F g 1at current density 1000 mA g 1in the charge/discharge mode.& 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved. | Khu Le Van Thu Thuy Luong Thi | 2014 | Progress in Natural Science:Materials International2014，24，3： | 7 |
| 6 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 7 | 云南省木薯产业的SWOT分析显示文摘运用SWOT方法对云南木薯(Manihot esculenta Crantz)产业的内部条件和外部环境作了详细分析,客观地指出了云南木薯产业发展具有的优势、劣势、机遇与威胁,并在此基础上提出云南木薯产业可持续发展的对策。 | 韩本勇 Nguyen Huu Luong 王昌梅 张无敌 | 2014 | 安徽农业科学2014，42，23： | 3 |
| 8 | The sensitivity and specificity of two methods for detecting Fasciola infections in cattle显示文摘 | Anderson N Luong T T Vo N G | 1999 | Vet Parasitol1999，83，： | 3 |
| 9 | Theoretical basis of a beneficial role for vitamin D in viral hepatitis显示文摘Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the pathology of viral hepatitis (i.e., the major histocompatibility complex class Ⅱ molecules, the vitamin D receptor, cytochrome P 450 , the renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, and the proteins regulated by the Sp1 promoter gene). Vitamin D also exerts its effects on viral hepatitis via non-genomic factors, i.e., matrix metalloproteinase, endothelial vascular growth factor, prostaglandins, cyclooxygenase-2, and oxidative stress. In conclusion, vitamin D could have a beneficial role in viral hepatitis. Calcitriol is best used for viral hepatitis because it is the active form of the vitamin D 3 metabolite. | Khanh vinh quoc Luong Lan Thi Hoàng Nguyen | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 10 | A Systematic Review of Microvascular Invasion in Hepatocellular Carcinoma: Diagnostic and Prognostic Variability显示文摘 | Manuel Rodríguez-Perálvarez Tu Vinh Luong Lorenzo Andreana Tim Meyer Amar Paul Dhillon Andrew Kenneth Burroughs | 2013 | Annals of Surgical Oncology2013，，1： | 3 |
| 11 | 软木塞基碳量子点的水热合成及其生物相融荧光成像应用显示文摘以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考,碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上,发现用碳量子点处理后,骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光,表明了碳量子点在荧光成像领域具有潜在的应用价值。 | Quang Ngo Khoa Hieu Nguyen Ngoc Bao Vo Van Quoc Phuoc Vo Thi Ngoc Le Xuan Diem Doc Luong Quang Tri Nguyen Minh Son Le Vu Truong Son Le Van Thanh Ha Che Thi Cam | 2022 | 新型炭材料2022，37，3： | 3 |
| 12 | Epoxy/graphene platelets nanocomposites with two levels of interface strength显示文摘 | Izzuddin Zaman Tam Thanh Phan Hsu-Chiang Kuan Qingshi Meng Ly Truc Bao La Lee Luong Osama Youssf Jun Ma | 2011 | Polymer2011，，7： | 2 |
| 13 | Use of light-emitting diode(LED)lamps in combination with metal halide(MH)lamps reduce fuel consumption in the Vietnamese purse seine fishery显示文摘The use of high-power lights during night-time purse seining is common in Vietnam.Typically,metal halide(MH)lamps are used in the commercial fishery to attract fish,however these lights require more energy,have a shorter lifespan,and lower chromatic performance than light emitting diode(LED)lamps.This study examined catch efficiency and fuel consumption when using LED lamps in combination with reduced numbers of MH lamps(10.24 kW),compared to conventional lighting(28.6 kW),used during purse seining off the coast of Ninh Thuan province,Vietnam.The economic performance associated with using LED lamps in this fishery was also assessed.We found no significant differences in catch rates between the different light treatments,however fuel consumption was significantly reduced.Fuel consumption per nightly trip using LED with MH lamps was 70.8 l(11.1 l/h)compared to114 l(17.45 l/hr)using MH lamps alone,an estimated 37.9%reduction in fuel consumption.An investment in LED lamps by a fishing enterprise will require additional initial costs,however our analysis revealed the financial break-event point can be reached after approximately 101 nightly trips when the fuel price is at the 2015 level of USD$0.74 per l.Fishing enterprises can increase their profitability,and reduce CO2 emissions,by using LED lamps in the Vietnamese purse seine fishery. | Khanh Q.Nguyen Phu D.Tran Luong T.Nguyen Phuong V.To Corey J.Morris | 2021 | Aquaculture and Fisheries2021，6，4： | 2 |
| 14 | NEW WEIGHTED MULTILINEAR OPERATORS AND COMMUTATORS OF HARDY-CESàRO TYPE显示文摘This paper deals with a general class of weighted multilinear Hardy-Cesaro operators that acts on the product of Lebesgue spaces and central Morrey spaces.Their sharp bounds are also obtained.In addition,we obtain sufficient and necessary conditions on weight functions so that the commutators of these weighted multilinear Hardy-Cesaro operators(with symbols in central BMO spaces) are bounded on the product of central Morrey spaces.These results extends known results on multilinear Hardy operators. | Ha Duy HUNG Luong Dang KY | 2015 | Acta Mathematica Scientia2015，35，6： | 2 |
| 15 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 16 | A NOTE ON H-w^p-BOUNDEDNESS OF RIESZ TRANSFORMS AND θ-CALDERóN-ZYGMUND OPERATORS THROUGH MOLECULAR CHARACTERIZATION显示文摘Let 0 < p ≤ 1 and w in the Muckenhoupt class A1. Recently, by using the weighted atomic decomposition and molecular characterization, Lee, Lin and Yang[11] es- tablished that the Riesz transforms Rj, j = 1,2,··· ,n, are bounded on Hwp(Rn). In this note we extend this to the general case of weight w in the Muckenhoupt class A∞ through molec- ular characterization. One difficulty, which has not been taken care in [11], consists in passing from atoms to all functions in Hwp(Rn). Furthermore, the Hwp-boundedness of θ- Calderón-Zygmund operators are also given through molecular characterization and atomic decomposition. | Luong Dang Ky | 2011 | Analysis in Theory and Applications2011，27，3： | 2 |
| 17 | Effects of urbanization on groundwater level in aquifers of Binh Duong Province,Vietnam显示文摘The purpose of this paper was to assess the impact of urbanization on the groundwater level(GWL)in aquifers of Binh Duong(BD)Province.The research method is to analyze the trend of GWL,the recharge capacity of surface over time and the relationship between them.The data of the GWL used in the study are the average values in the dry and rainy seasons of 35 observation wells from 2011 to 2018,which are in Pleistocene and Pliocene aquifers.The ability to recharge groundwater from the surface in this study was represented by the curve number(CN),a parameter used in hydrology for calculating direct runoff or infiltration from rainfall.The land use data to identify the CN was analyzed from the Landsat images.The results show that besides over-exploitation,the change of surface characteristic due to the urbanization development process is also the cause of the GWL decline.The analysis of seasonal GWL data shows that the increase in impervious surface area is the cause of GWL decline in the Pleistocene aquifer,which is more evident in the rainy season than in the dry season.The statistical results also show that in the rainy season and in shallow aquifers,a higher CN change can be found with the wells that had a remarkable GWL decline compared to the remaining wells. | Luong Van Viet | 2021 | Journal of Groundwater Science and Engineering2021，9，1： | 2 |
| 18 | Scale-up of biomass conversion using 1-ethyl-3-methylimidazolium acetate as the solvent显示文摘This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified. | Ling Liang Jipeng Yan Qian He Tina Luong Todd R.Pray Blake A.Simmons Ning Sun | 2019 | Green Energy & Environment2019，4，4： | 2 |
| 19 | Fatigue limit evaluation of metals using an infrared thermographic technique 显示文摘 | Minh Phong Luong | 1998 | Mechanics of Materials1998，28，： | 1 |
| 20 | A 2-V 900MHz Monolithic CMOS Dual-Loop Frequency Synthesizer for GSM Receivers显示文摘 | Yan W S T Luong H C | 2001 | IEEE J of Solid-State Circuit2001，36，2： | 1 |
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