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| 1 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 2 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | LUO Changling BANAKAR H BAIKE S | 2007 | Energy Conversion2007，22，2： | 1 |
| 3 | Strategies to Smooth Wind Power Fluctuations of Wind Turbine Generator显示文摘 | Changling Luo Banakar H Baike Shen | 2007 | IEEE Trans on Energy Conversion2007，22，2： | 1 |
| 4 | Frequency deviation of thermal power plants due to wind farms显示文摘 | LUO Changling BOON-TECK O | 2006 | Energy Conversion2006，21，3： | 1 |
| 5 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | BANAKAR H LUO Changling BOON T O | 2008 | Power Systems2008，23，1： | 1 |
| 6 | Impacts of windpower minute-to-minute variations on power systemoperation显示文摘 | Banakar H Luo Changling Ooi B T | 2008 | IEEE Trans on Power Systems2008，23，1： | 1 |
| 7 | Frequency deviation of thermal power plants due to wind farms显示文摘 | Luo Changling Boon-reck O | 2006 | Energy Conversion2006，21，3： | 1 |
| 8 | Frequency deviation of thermal power plants due to wind farms 显示文摘 | Changling Luo Boon-Teck Ooi | 2006 | IEEE Trans on Energy Conversion2006，21，3： | 1 |
| 9 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | Banakar H Luo Changling Ooi B T | 2008 | IEEE Transactions on Power Systems2008，23，1： | 1 |
| 10 | Impacts of wind power minute-to-minute variations on power system operation 显示文摘 | Hadi B Luo Changling Boon T O | 2008 | IEEE Trans on Power Systems2008，23，1： | 1 |
| 11 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | Hadi B Luo Changling Boon T O | 2008 | IEEE Trans on Power Systems2008，23，1： | 1 |
| 12 | Frequency deviation of thermal power plants due to wind farms 显示文摘 | Luo Changling Boon-Teck Ooi | 2006 | IEEE Transactions on Energy Conversion2006，21，3： | 1 |
| 13 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | Luo Changling Banakar Hadi Shen Baike | 2007 | IEEE Trans on Energy Conver- sion2007，22，2： | 1 |
| 14 | Strategies to Smooth Wind Power Fluctuations of Wind Turbine Generator显示文摘 | Luo Changling Banakar Hadi Shen Baike | 2007 | IEEE Transactions on Energy Conversion2007，22，2： | 1 |
| 15 | Strategies to smooth wind power fluctuations of wind turbine generator 显示文摘 | LUO Changling BANAKAR H SHEN Baike | 2007 | IEEE Trans on Energy Conversion2007，22，2： | 1 |
| 16 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | Luo Changling Banakar Hadi Shen Baike | 2007 | IEEE Transactions on Energy Conversion2007，22，2： | 1 |
| 17 | Frequency deviation of thermal power plants due to wind farms显示文摘 | LUO Changling BOONTECK O | 2006 | IEEE Trans on Energy Con- version2006，21，3： | 1 |
| 18 | Frequency deviation o显示文摘 | LUO Changling OOI B T | 2006 | IEEE Trans on Energy Conversion2006，21，3： | 1 |
| 19 | Strategies to Smooth Wind Power Fluctuations of Wind turbine Generator显示文摘 | Luo Changling Banakar H Shen Baike | | 0，，02： | 1 |
| 20 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | Banakar H Luo Changling Boon T O | 2008 | IEEE Trans on Power Systems2008，23，1： | 1 |
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