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| 1 | 1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital显示文摘AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat hepatocarcinogenesis.METHODS:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline once.After a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK 20.Group C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a week.Group E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 wk.The rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN injection.RESULTS:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal controls.Continuous supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed cells.Furthermore,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,25-dihydroxyvitaminD3.CONCLUSION:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital. | Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 2 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | LUO Changling BANAKAR H BAIKE S | 2007 | Energy Conversion2007，22，2： | 1 |
| 3 | Strategies to Smooth Wind Power Fluctuations of Wind Turbine Generator显示文摘 | Changling Luo Banakar H Baike Shen | 2007 | IEEE Trans on Energy Conversion2007，22，2： | 1 |
| 4 | Growth response of a deep-water ferromanganese crust to evolution of the Neogene Indian Ocean显示文摘 | Banakar V K Hein J R | 2000 | Marine Geology2000，162，2： | 1 |
| 5 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | Banakar H Luo C L Ooi B T | 2008 | IEEE Transactions on Power Systems2008，23，1： | 1 |
| 6 | Himalayan sedimentary pulses recorded by silicate detritus within a fer- romanganese crust from the Central Indian Ocean显示文摘 | Banakar V K Galy A Sukumaran N P | 2003 | Earth and Planetary Science Letters2003，205，3： | 1 |
| 7 | Macromodel of spatial smoothing in wind farms显示文摘 | LI Pei KEUNG P K BANAKAR H | 2007 | Energy Conversion2007，22，1： | 1 |
| 8 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | LUO Chang-ling Banakar H SHEN Bai-ke | 2007 | IEEE Trans on Energy Conversion2007，22，2： | 1 |
| 9 | Kinetic energy of windturbine generators for system frequency support显示文摘 | Keung P K Lei P Banakar H Ooi B T | | 0，，01： | 1 |
| 10 | A Comparison of Mathe- matical and Artificial Neural Network Modeling for Rose Petals Using Hot Air Drying Method显示文摘 | Banakar ahmad Karimi akandi S R | 2012 | International Jour- nal of Computational Intelligence and Applications2012，11，12： | 1 |
| 11 | Kinetic energy of wind turbine generators for system frequency support显示文摘 | Keung P K Li P Banakar H | 2009 | IEEE Transactions on Power Systems2009，24，1： | 1 |
| 12 | Impacts of wind power minute-to-minute variations on power system operation显示文摘 | BANAKAR H LUO Changling BOON T O | 2008 | Power Systems2008，23，1： | 1 |
| 13 | Palaeoceanographic conditions during the formation of a ferromanganese crust from the Afanasiy-Nikitin Seamount, north central Indian Ocean: geochemical evidence 显示文摘 | BANAKAR V K PATTAN J N MUDHOLKAR A V | 1997 | Mar Geol1997，136，： | 1 |
| 14 | Impacts of Wind Power Minute-to-Minute Variations on Power System Operation显示文摘 | BANAKAR H LUO C L OOI B T | 2008 | IEEE Transaction on Power System2008，23，1： | 1 |
| 15 | Impacts of windpower minute-to-minute variations on power systemoperation显示文摘 | Banakar H Luo Changling Ooi B T | 2008 | IEEE Trans on Power Systems2008，23，1： | 1 |
| 16 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | Luo C L Banakar H Shen B K | 2007 | IEEE Transactions on Energy Conversion2007，22，2： | 1 |
| 17 | Strategies to smooth wind power fluctuations of wind turbine genera- tor显示文摘 | LUO C BANAKAR H SHEN B l | 2007 | IEEE Trans on Energy Conversion2007，22，2： | 1 |
| 18 | Bacillus thuringiensis:a century of research,development and commercial applications显示文摘 | Sanahuja G Banakar R Twyman RM | | 0，，03： | 1 |
| 19 | Strategies to smooth wind power fluctuations of wind turbine generator显示文摘 | Luo C Banakar H Shen B | 2007 | IEEE Transactions on Energy Conversion2007，22，2： | 1 |
| 20 | Bacillus thuringiensis:a century of research,development and commercial applications显示文摘 | Sanahuja G Banakar R Twyman R M | 2011 | Plant Biotechnology Journal2011，9，3： | 1 |
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